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Published in: Journal of Gastroenterology 1/2012

01-01-2012 | Original Article—Liver, Pancreas, and Biliary Tract

Is cholecystectomy necessary after endoscopic treatment of bile duct stones in patients older than 80 years of age?

Authors: Takaharu Yasui, Shunichi Takahata, Hiroshi Kono, Yosuke Nagayoshi, Yasuhisa Mori, Kosuke Tsutsumi, Yoshihiko Sadakari, Takao Ohtsuka, Masafumi Nakamura, Masao Tanaka

Published in: Journal of Gastroenterology | Issue 1/2012

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Abstract

Background and aims

Although patients with cholecystocholedocholithiasis are generally referred to cholecystectomy after endoscopic sphincterotomy (ES) and common bile duct clearance, we often have a conflict whether cholecystectomy is necessary in very elderly patients with comorbid diseases. The aim of this study is to assess whether cholecystectomy in very elderly patients is justified after ES.

Patients and methods

Patients with cholecystocholedocholithiasis who underwent ES and stone extraction and were followed-up for more than 10 years were retrospectively reviewed. We divided these patients into two groups: the elderly group (equal to or more than 80 years old) and young group (less than 80 years old) and compared late biliary complications and mortality.

Results

The 10-year cumulative incidence of overall biliary complications was significantly lower in cholecystectomized patients than in patients with gallbladder in situ in the young group (7.5 vs. 21.7%, p = 0.0037), but not different in the elderly group (8.3 vs. 7.4%, p = 0.92). When each complication was evaluated separately, the rate of recurrent common bile duct stones (CBDS) was not different, but that of acute cholecystitis was significantly lower in the elderly group than in the young group (4.1 vs. 22.6%, p = 0.011).

Conclusions

In very elderly patients the incidence of acute cholecystitis is low even when the gallbladder is preserved after endoscopic treatment of CBDS, with a similar risk of CBDS recurrence. Thus, it may not be necessary to recommend cholecystectomy after ES for CBDS in very elderly patients.
Literature
1.
go back to reference Dubois F, Icard P, Berthelot H, Levard G. Coelioscopic cholecystectomy. Preliminary report of 36 cases. Ann Surg. 1990;211:60–2.PubMedCrossRef Dubois F, Icard P, Berthelot H, Levard G. Coelioscopic cholecystectomy. Preliminary report of 36 cases. Ann Surg. 1990;211:60–2.PubMedCrossRef
2.
go back to reference Tanaka M, Ikeda S, Yoshimoto H, Matsumoto S. The long-term fate of the gallbladder after endoscopic sphincterotomy. Complete follow-up study of 122 patients. Am J Surg. 1987;154:505–9.PubMedCrossRef Tanaka M, Ikeda S, Yoshimoto H, Matsumoto S. The long-term fate of the gallbladder after endoscopic sphincterotomy. Complete follow-up study of 122 patients. Am J Surg. 1987;154:505–9.PubMedCrossRef
3.
go back to reference Kageoka M, Watanabe F, Maruyama Y, Nagata K, Ohata A, Noda Y, et al. Long-term prognosis of patients after endoscopic sphincterotomy for choledocholithiasis. Dig Endosc. 2009;21:170–5.PubMedCrossRef Kageoka M, Watanabe F, Maruyama Y, Nagata K, Ohata A, Noda Y, et al. Long-term prognosis of patients after endoscopic sphincterotomy for choledocholithiasis. Dig Endosc. 2009;21:170–5.PubMedCrossRef
4.
go back to reference Pereira-Lima JC, Jakobs R, Winter UH, Benz C, Martin WR, Adamek HE, et al. Long-term results (7 to 10 years) of endoscopic papillotomy for choledocholithiasis. Multivariate analysis of prognostic factors for the recurrence of biliary symptoms. Gastrointest Endosc. 1998;48:457–64.PubMedCrossRef Pereira-Lima JC, Jakobs R, Winter UH, Benz C, Martin WR, Adamek HE, et al. Long-term results (7 to 10 years) of endoscopic papillotomy for choledocholithiasis. Multivariate analysis of prognostic factors for the recurrence of biliary symptoms. Gastrointest Endosc. 1998;48:457–64.PubMedCrossRef
5.
go back to reference Sanjay P, Yeeting S, Whigham C, Judson H, Polignano FM, Tait IS. Endoscopic sphincterotomy and interval cholecystectomy are reasonable alternatives to index cholecystectomy in severe acute gallstone pancreatitis (GSP). Surg Endosc. 2008;22:1832–7.PubMedCrossRef Sanjay P, Yeeting S, Whigham C, Judson H, Polignano FM, Tait IS. Endoscopic sphincterotomy and interval cholecystectomy are reasonable alternatives to index cholecystectomy in severe acute gallstone pancreatitis (GSP). Surg Endosc. 2008;22:1832–7.PubMedCrossRef
6.
go back to reference Lee KM, Paik CN, Chung WC, Kim JD, Lee CR, Yang JM. Risk factors for cholecystectomy in patients with gallbladder stones after endoscopic clearance of common bile duct stones. Surg Endosc. 2009;23:1713–9.PubMedCrossRef Lee KM, Paik CN, Chung WC, Kim JD, Lee CR, Yang JM. Risk factors for cholecystectomy in patients with gallbladder stones after endoscopic clearance of common bile duct stones. Surg Endosc. 2009;23:1713–9.PubMedCrossRef
7.
go back to reference Boerma D, Rauws EA, Keulemans YC, Janssen IM, Bolwerk CJ, Timmer R, et al. Wait-and-see policy or laparoscopic cholecystectomy after endoscopic sphincterotomy for bile-duct stones: a randomised trial. Lancet. 2002;360:761–5.PubMedCrossRef Boerma D, Rauws EA, Keulemans YC, Janssen IM, Bolwerk CJ, Timmer R, et al. Wait-and-see policy or laparoscopic cholecystectomy after endoscopic sphincterotomy for bile-duct stones: a randomised trial. Lancet. 2002;360:761–5.PubMedCrossRef
8.
go back to reference Lau JY, Leow CK, Fung TM, Suen BY, Yu LM, Lai PB, et al. Cholecystectomy or gallbladder in situ after endoscopic sphincterotomy and bile duct stone removal in Chinese patients. Gastroenterology. 2006;130:96–103.PubMedCrossRef Lau JY, Leow CK, Fung TM, Suen BY, Yu LM, Lai PB, et al. Cholecystectomy or gallbladder in situ after endoscopic sphincterotomy and bile duct stone removal in Chinese patients. Gastroenterology. 2006;130:96–103.PubMedCrossRef
9.
go back to reference Schreurs WH, Vles WJ, Stuifbergen WH, Oostvogel HJ. Endoscopic management of common bile duct stones leaving the gallbladder in situ. A cohort study with long-term follow-up. Dig Surg. 2004;21:60–4. (discussion 65).PubMedCrossRef Schreurs WH, Vles WJ, Stuifbergen WH, Oostvogel HJ. Endoscopic management of common bile duct stones leaving the gallbladder in situ. A cohort study with long-term follow-up. Dig Surg. 2004;21:60–4. (discussion 65).PubMedCrossRef
10.
go back to reference Hammarstrom LE, Holmin T, Stridbeck H. Endoscopic treatment of bile duct calculi in patients with gallbladder in situ: long-term outcome and factors. Scand J Gastroenterol. 1996;31:294–301.PubMedCrossRef Hammarstrom LE, Holmin T, Stridbeck H. Endoscopic treatment of bile duct calculi in patients with gallbladder in situ: long-term outcome and factors. Scand J Gastroenterol. 1996;31:294–301.PubMedCrossRef
11.
go back to reference Kwon SK, Lee BS, Kim NJ, Lee HY, Chae HB, Youn SJ, et al. Is cholecystectomy necessary after ERCP for bile duct stones in patients with gallbladder in situ? Korean J Intern Med. 2001;16:254–9.PubMed Kwon SK, Lee BS, Kim NJ, Lee HY, Chae HB, Youn SJ, et al. Is cholecystectomy necessary after ERCP for bile duct stones in patients with gallbladder in situ? Korean J Intern Med. 2001;16:254–9.PubMed
12.
go back to reference Kim HO, Yun JW, Shin JH, Hwang SI, Cho YK, Son BH, et al. Outcome of laparoscopic cholecystectomy is not influenced by chronological age in the elderly. World J Gastroenterol. 2009;15:722–6.PubMedCrossRef Kim HO, Yun JW, Shin JH, Hwang SI, Cho YK, Son BH, et al. Outcome of laparoscopic cholecystectomy is not influenced by chronological age in the elderly. World J Gastroenterol. 2009;15:722–6.PubMedCrossRef
14.
go back to reference Uchiyama K, Onishi H, Tani M, Kinoshita H, Kawai M, Ueno M, et al. Long-term prognosis after treatment of patients with choledocholithiasis. Ann Surg. 2003;238:97–102.PubMed Uchiyama K, Onishi H, Tani M, Kinoshita H, Kawai M, Ueno M, et al. Long-term prognosis after treatment of patients with choledocholithiasis. Ann Surg. 2003;238:97–102.PubMed
15.
16.
go back to reference Bernhoft RA, Pellegrini CA, Motson RW, Way LW. Composition and morphologic and clinical features of common duct stones. Am J Surg. 1984;148:77–85.PubMedCrossRef Bernhoft RA, Pellegrini CA, Motson RW, Way LW. Composition and morphologic and clinical features of common duct stones. Am J Surg. 1984;148:77–85.PubMedCrossRef
17.
go back to reference Trotman BW, Soloway RD. Pigment vs cholesterol cholelithiasis: clinical and epidemiological aspects. Am J Dig Dis. 1975;20:735–40.PubMedCrossRef Trotman BW, Soloway RD. Pigment vs cholesterol cholelithiasis: clinical and epidemiological aspects. Am J Dig Dis. 1975;20:735–40.PubMedCrossRef
18.
go back to reference Iso H, Date C, Noda H, Yoshimura T, Tamakoshi A. Frequency of food intake and estimated nutrient intake among men and women: the JACC study. J Epidemiol. 2005;15(Suppl 1):S24–42.PubMedCrossRef Iso H, Date C, Noda H, Yoshimura T, Tamakoshi A. Frequency of food intake and estimated nutrient intake among men and women: the JACC study. J Epidemiol. 2005;15(Suppl 1):S24–42.PubMedCrossRef
Metadata
Title
Is cholecystectomy necessary after endoscopic treatment of bile duct stones in patients older than 80 years of age?
Authors
Takaharu Yasui
Shunichi Takahata
Hiroshi Kono
Yosuke Nagayoshi
Yasuhisa Mori
Kosuke Tsutsumi
Yoshihiko Sadakari
Takao Ohtsuka
Masafumi Nakamura
Masao Tanaka
Publication date
01-01-2012
Publisher
Springer Japan
Published in
Journal of Gastroenterology / Issue 1/2012
Print ISSN: 0944-1174
Electronic ISSN: 1435-5922
DOI
https://doi.org/10.1007/s00535-011-0461-3

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