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International Journal of Behavioral Medicine

Published in:

01-09-2009

Is Brachial Artery Flow-Mediated Dilation Associated with Negative Affect?

Authors: Laura L. Schott, Thomas W. Kamarck, Karen A. Matthews, Sarah E. Brockwell, Kim Sutton-Tyrrell

Published in: International Journal of Behavioral Medicine | Issue 3/2009

Abstract

Background

Trait negative affect has been implicated as a risk marker for cardiovascular disease, but the mechanisms underlying this association are uncertain.

Purpose

Our aim was to examine associations between trait measures of anger, hostility, depression, and anxiety with endothelial dysfunction via brachial artery flow-mediated dilation (FMD), an early indicator of cardiovascular disease.

Method

FMD was examined in 332 healthy older adults. Measures included Beck Anxiety and Depression Inventories, Cook–Medley Hostility Scale, and Spielberger State-Trait Anger Expression Inventory (Anger In, Anger Out, and Trait Anger).

Results

Mean age was 60.5 ± 4.8 years; 83% of participants were Caucasian and 49% were female. FMD was greater in women compared to men (6.17% vs. 4.07%, p < 0.001). Women reported significantly greater Anxiety (p < 0.001), and men reported greater Hostility (p = 0.004). In separate multivariable linear regression models controlling for cardiovascular risk factors, plus current hormone therapy for women, smaller FMD was associated with higher Anger In for women (β = −0.222, p = 0.04) and showed a trend with higher Hostility for men (β = −0.082, p = 0.09).

Conclusion

Endothelial dysfunction, as indicated by less vasodilatation of the brachial artery, is positively associated with measures of hostility and anger suppression in healthy older adults. Thus, associations between negative affect and cardiovascular health may be apparent early in the disease process.

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Title: Is Brachial Artery Flow-Mediated Dilation Associated with Negative Affect?
Authors: Laura L. Schott
Thomas W. Kamarck
Karen A. Matthews
Sarah E. Brockwell
Kim Sutton-Tyrrell
Publication date: 01-09-2009
Publisher: Springer US
Published in: International Journal of Behavioral Medicine / Issue 3/2009
Print ISSN: 1070-5503
Electronic ISSN: 1532-7558
DOI: https://doi.org/10.1007/s12529-009-9038-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Is Brachial Artery Flow-Mediated Dilation Associated with Negative Affect?

Abstract

Background

Purpose

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Purpose

Method

Results

Conclusion

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