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International Journal of Behavioral Medicine
Published in: International Journal of Behavioral Medicine 3/2009

01-09-2009

Long-Term Effects of a Multimodal Behavioral Intervention on Myocardial Perfusion—a Randomized Controlled Trial

Authors: Christian Albus, Peter Theissen, Martin Hellmich, Reinhard Griebenow, Beate Wilhelm, Demet Aslim, Harald Schicha, Karl Köhle

Published in: International Journal of Behavioral Medicine | Issue 3/2009

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Abstract

Background

Recent advances in drug therapy question as to the additional impact behavioral interventions may have on the prognosis of patients with clinically stable coronary heart disease (CHD).

Purpose

The aim of the study was to evaluate the effects of a multimodal, behavioral intervention on myocardial perfusion (MP) and cardiac events, compared to standardized cardiologic care, in patients with stable CHD.

Methods

Seventy-seven CHD patients (age 54.2 ± 6.9 years, male 87%) were randomly assigned to a behavioral intervention plus standardized cardiologic care (INT, n = 39) or standardized cardiologic care alone (CO, n = 38). MP was assessed by 201Thallium MP-scintigrams (SPECT) at baseline, after 2, 3, and 7 years, respectively. Subsequent cardiac events (MI, PCI, CABG) were assessed using the cardiologists’ charts.

Results

Sixty-five patients (84%) completed the study. In all patients, the course of MP was significantly better in INT analysis of variance (ANOVA group × time p = 0.001); this was also true for patients without subsequent PCI/CABG (ANOVA group × time p = 0.002). Incidence of cardiac events was significantly associated with INT (6 vs. 14; log rank test p = .047).

Conclusion

The study suggests additional long-term benefits of a behavioral intervention on myocardial perfusion and cardiac events in patients with stable CHD compared to standardized cardiologic care only.
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Metadata
Title
Long-Term Effects of a Multimodal Behavioral Intervention on Myocardial Perfusion—a Randomized Controlled Trial
Authors
Christian Albus
Peter Theissen
Martin Hellmich
Reinhard Griebenow
Beate Wilhelm
Demet Aslim
Harald Schicha
Karl Köhle
Publication date
01-09-2009
Publisher
Springer US
Published in
International Journal of Behavioral Medicine / Issue 3/2009
Print ISSN: 1070-5503
Electronic ISSN: 1532-7558
DOI
https://doi.org/10.1007/s12529-008-9030-4

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