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BMC Gastroenterology
Published in: BMC Gastroenterology 1/2023

Open Access 01-12-2023 | Irritable Bowel Syndrome | Research

Triptolide attenuates irritable bowel syndrome via inhibiting ODC1

Authors: Ning Zhu, Liuyan Zhu, Xueliang Zhang, Chengbin Huang, Wenjun Xiang, Bingwu Huang

Published in: BMC Gastroenterology | Issue 1/2023

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Abstract

Background

Irritable bowel syndrome (IBS) is a chronic disorder of the gut-brain axis with significant morbidity. Triptolide, an active compound extracted from Tripterygium wilfordii Hook F (TwHF), has been widely used as a major medicinal herb in the treatment of inflammatory disease.

Methods

The chronic-acute combined stress (CAS) stimulation was used to establish IBS rat model. The model rats were then gavaged with triptolide. Forced swimming, marble-burying, fecal weight and abdominal withdrawal reflex (AWR) score were recorded. Pathologic changes in the ileal and colonic tissues were validated by hematoxylin and eosin staining. The inflammatory cytokines and Ornithine Decarboxylase-1 (ODC1) in the ileal and colonic tissues were performed by ELISA and WB.

Results

Triptolide didn’t have antidepressant- and antianxiety- effects in rats caused by CAS, but decreased fecal weight and AWR score. In addition, Triptolide reduced the release of IL-1, IL-6, and TNF-α and the expression of ODC1 in the ileum and colon.

Conclusion

The therapeutic efficacy of triptolide for IBS induced by CAS was revealed in this study, which may be related to the reduction of ODC1.
Appendix
Available only for authorised users
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Metadata
Title
Triptolide attenuates irritable bowel syndrome via inhibiting ODC1
Authors
Ning Zhu
Liuyan Zhu
Xueliang Zhang
Chengbin Huang
Wenjun Xiang
Bingwu Huang
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2023
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/s12876-023-02847-8

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