Skip to main content
Top
Published in: Intensive Care Medicine 12/2018

01-12-2018 | Editorial

Iron deficiency and infection: another pathway to explore in critically ill patients?

Authors: Erik R. Swenson, Raphaël Porcher, Michaël Piagnerelli

Published in: Intensive Care Medicine | Issue 12/2018

Login to get access

Excerpt

Anaemia is a common pathology with a high prevalence and incidence in the general population worldwide and one of the leading causes of years lived with disability and of mortality in myriad chronic medical illnesses [1]. Aetiologies are different depending especially on age and geographical location. In a systematic analysis for the Global Burden of Disease, Kassenbaum et al. [2] reported that iron-deficiency anaemia, haemoglobinopathies and parasitic diseases were the most frequent causes of anaemia worldwide. …
Literature
1.
go back to reference Hayden SJ, Albert TJ, Watkins TR, Swenson ER (2012) Anemia in critical illness: insights into etiology, consequences, and management. Am J Respir Crit Care Med 185:1049–1057CrossRefPubMedPubMedCentral Hayden SJ, Albert TJ, Watkins TR, Swenson ER (2012) Anemia in critical illness: insights into etiology, consequences, and management. Am J Respir Crit Care Med 185:1049–1057CrossRefPubMedPubMedCentral
2.
go back to reference Kassebaum NJ, Jasrasaria R, Naghavi M, Wulf SK, Johns N, Lozano R, Regan M, Weatherall D, Chou DP, Eisele TP, Flaxman SR, Pullan RL, Brooker SJ, Murray CJ (2014) A systematic analysis of global anemia burden from 1990 to 2010. Blood 123:615–624CrossRefPubMedPubMedCentral Kassebaum NJ, Jasrasaria R, Naghavi M, Wulf SK, Johns N, Lozano R, Regan M, Weatherall D, Chou DP, Eisele TP, Flaxman SR, Pullan RL, Brooker SJ, Murray CJ (2014) A systematic analysis of global anemia burden from 1990 to 2010. Blood 123:615–624CrossRefPubMedPubMedCentral
3.
go back to reference Stauder R, Valer P, Theurl I (2018) Anemia at older age: etiologies, clinical implication, and management. Blood 131:505–514CrossRefPubMed Stauder R, Valer P, Theurl I (2018) Anemia at older age: etiologies, clinical implication, and management. Blood 131:505–514CrossRefPubMed
4.
go back to reference Ferrucci L, Guralnik JM, Bandinelli S, Semba RD, Lauretani F, Corsi A, Ruggerio C, Ershler WB, Longo DL (2007) Types of anaemia in older patients is characterised by low levels of erythropoietin and levels of pro-inflammatory markers. Br J Haematol 136:849–855CrossRefPubMedPubMedCentral Ferrucci L, Guralnik JM, Bandinelli S, Semba RD, Lauretani F, Corsi A, Ruggerio C, Ershler WB, Longo DL (2007) Types of anaemia in older patients is characterised by low levels of erythropoietin and levels of pro-inflammatory markers. Br J Haematol 136:849–855CrossRefPubMedPubMedCentral
6.
go back to reference Pagani A, Nai A, Corna G, Bosurgi L, Rovere-Querini P, Camaschella C, Silvestri L (2011) Low hepcidin accounts for the proinflammatory status associated with iron deficiency. Blood 118:736–746CrossRefPubMed Pagani A, Nai A, Corna G, Bosurgi L, Rovere-Querini P, Camaschella C, Silvestri L (2011) Low hepcidin accounts for the proinflammatory status associated with iron deficiency. Blood 118:736–746CrossRefPubMed
8.
go back to reference Mohus RM, Paulsen J, Gustad L, Askim L, Askim A, Mehl A, DeWan AT, Afset JE, Asvold BO, Solligard E, Damas JK (2018) Association of iron status with the risk of bloodstream infections: results from the prospective population-based HUNT Study in Norway. Intens Care Med 44:1276–1283CrossRef Mohus RM, Paulsen J, Gustad L, Askim L, Askim A, Mehl A, DeWan AT, Afset JE, Asvold BO, Solligard E, Damas JK (2018) Association of iron status with the risk of bloodstream infections: results from the prospective population-based HUNT Study in Norway. Intens Care Med 44:1276–1283CrossRef
9.
go back to reference Fonseca C, Marques F, Robalo Nunes A, Belo A et al (2016) Prevalence of anaemia and iron deficiency in Portugal: the EMPIRE study. Intern Med J 46:470–478CrossRefPubMed Fonseca C, Marques F, Robalo Nunes A, Belo A et al (2016) Prevalence of anaemia and iron deficiency in Portugal: the EMPIRE study. Intern Med J 46:470–478CrossRefPubMed
10.
go back to reference Vincent JL, Piagnerelli M (2006) Transfusion in the intensive care unit. Crit Care Med 34:S96–S101CrossRefPubMed Vincent JL, Piagnerelli M (2006) Transfusion in the intensive care unit. Crit Care Med 34:S96–S101CrossRefPubMed
11.
go back to reference Piagnerelli M, Cotton F, Herpain A, Rapotec A, Chatti R, Gulbis B, Vincent JL (2013) Time course of iron metabolism in critically ill patients. Acta Clin Belg 68:22–27CrossRefPubMed Piagnerelli M, Cotton F, Herpain A, Rapotec A, Chatti R, Gulbis B, Vincent JL (2013) Time course of iron metabolism in critically ill patients. Acta Clin Belg 68:22–27CrossRefPubMed
12.
go back to reference Boshuizen M, Binnekade JM, Nota B, van de Groen K, Cremer OL, Tuinman PR, Horn J, van Bruggen R, Juffermans NP, Molecular Diagnosis and Risk Stratification of Sepsis (MARS) Consortium (2018) Iron metabolism in critically ill patients developing anemia of inflammation: a case control study. Ann Intens Care 8:56CrossRef Boshuizen M, Binnekade JM, Nota B, van de Groen K, Cremer OL, Tuinman PR, Horn J, van Bruggen R, Juffermans NP, Molecular Diagnosis and Risk Stratification of Sepsis (MARS) Consortium (2018) Iron metabolism in critically ill patients developing anemia of inflammation: a case control study. Ann Intens Care 8:56CrossRef
13.
go back to reference Stefanova D, Raychev A, Deville J, Humphries R, Campeau S, Ruchala P, Nemeth E, Ganz T, Bulut Y (2018) Hepcidin protects against lethal Escherichia coli sepsis in mice inoculated with isolates from septic patients. Infect Immun 86:e00253-18CrossRefPubMed Stefanova D, Raychev A, Deville J, Humphries R, Campeau S, Ruchala P, Nemeth E, Ganz T, Bulut Y (2018) Hepcidin protects against lethal Escherichia coli sepsis in mice inoculated with isolates from septic patients. Infect Immun 86:e00253-18CrossRefPubMed
14.
go back to reference Stefanova D, Raychev A, Arezes J, Ruchala P, Gabayan V, Skurnik M, Dillon BJ, Horwitz MA, Ganz T, Bulut Y, Nemeth E (2017) Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron. Blood 130:245–257CrossRefPubMedPubMedCentral Stefanova D, Raychev A, Arezes J, Ruchala P, Gabayan V, Skurnik M, Dillon BJ, Horwitz MA, Ganz T, Bulut Y, Nemeth E (2017) Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron. Blood 130:245–257CrossRefPubMedPubMedCentral
15.
go back to reference Theurl I, Schroll A, Sonnweber T, Nairz M, Theurl M, Willenbacher W, Eller K, Wolf D, Seifert M, Sun CC, Babitt JL, Hong CC, Menhall T, Gearing P, Lin HY, Weiss G (2011) Pharmacologic inhibition of hepcidin expression reverse anemia of chronic inflammation in rats. Blood 118:4977–4984CrossRefPubMedPubMedCentral Theurl I, Schroll A, Sonnweber T, Nairz M, Theurl M, Willenbacher W, Eller K, Wolf D, Seifert M, Sun CC, Babitt JL, Hong CC, Menhall T, Gearing P, Lin HY, Weiss G (2011) Pharmacologic inhibition of hepcidin expression reverse anemia of chronic inflammation in rats. Blood 118:4977–4984CrossRefPubMedPubMedCentral
16.
go back to reference IRONMAN Investigators, Litton E, Baker S, Erber WN, Farmer S, Ferrier J, French C, Gummer J, Hawkins D, Higgins A, Hofmann A, De Keulenaer B, McMorrow J, Olynyk JK, Richards T, Towler S, Trengove R, Webb S, Australian and New Zealand Intensive Care Society Clinical Trials Group (2016) Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicenter randomized blind trial: a randomized trial of IV iron in critical illness. Intens Care Med 42:1715–1722CrossRef IRONMAN Investigators, Litton E, Baker S, Erber WN, Farmer S, Ferrier J, French C, Gummer J, Hawkins D, Higgins A, Hofmann A, De Keulenaer B, McMorrow J, Olynyk JK, Richards T, Towler S, Trengove R, Webb S, Australian and New Zealand Intensive Care Society Clinical Trials Group (2016) Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicenter randomized blind trial: a randomized trial of IV iron in critical illness. Intens Care Med 42:1715–1722CrossRef
17.
go back to reference Pierraci FM, Stovall RT, Jaouen B, Rodil M, Cappa A, Burlew CC, Holena DN, Maier R, Berry S, Jurkovich J, Moore EE (2014) A multicenter, randomized clinical trial of IV iron supplementation for anemia of traumatic critical illness. Crit Care Med 42:2048–2057CrossRef Pierraci FM, Stovall RT, Jaouen B, Rodil M, Cappa A, Burlew CC, Holena DN, Maier R, Berry S, Jurkovich J, Moore EE (2014) A multicenter, randomized clinical trial of IV iron supplementation for anemia of traumatic critical illness. Crit Care Med 42:2048–2057CrossRef
Metadata
Title
Iron deficiency and infection: another pathway to explore in critically ill patients?
Authors
Erik R. Swenson
Raphaël Porcher
Michaël Piagnerelli
Publication date
01-12-2018
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 12/2018
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-018-5438-8

Other articles of this Issue 12/2018

Intensive Care Medicine 12/2018 Go to the issue

Imaging in Intensive Care Medicine

Cutaneous infection with Mycobacterium abscessus