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01-09-2016 | Original Paper

iRhom2 ^Uncv mutation blocks bulge stem cells assuming the fate of hair follicle

Authors: Leilei Yang, Wenlong Li, Bing Liu, Shaoxia Wang, Lin Zeng, Cuiping Zhang, Yang Li

Published in: Archives of Dermatological Research | Issue 7/2016

Abstract

iRhom2 is necessary for maturation of TNFα-converting enzyme, which is required for the release of tumor necrosis factor. In the previous study, we found that the iRhom2 ^Uncv mutation in N-terminal cytoplasmic domain-encoding region (iRhom2^Uncv) leads to aberrant hair shaft and inner root sheath differentiation, thus results in a hairless phenotype in homozygous iRhom2 ^Uncv/Uncv BALB/c mice. In this study, we found iRhom2 mutation decreased hair matrix proliferation, however, iRhom2 ^Uncv/Uncv mice displayed hyperproliferation and hyperkeratosis in the interfollicular epidermis along with hypertrophy in the sebaceous glands. The number of bulge SCs was not altered and the hair follicle cycle is normal in iRhom2 ^Uncv/Uncv mice. The decreased proliferation in hair matrix but increased proliferation in epidermis and sebaceous glands in iRhom2 ^Uncv/Uncv mice may implying that iRhom2 ^Uncv mutation blocks bugle stem cells assuming the fate of hair follicle. This study identifies iRhom2 as a novel regulator for determination of keratinocyte lineages.

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Title: iRhom2 Uncv mutation blocks bulge stem cells assuming the fate of hair follicle
Authors: Leilei Yang
Wenlong Li
Bing Liu
Shaoxia Wang
Lin Zeng
Cuiping Zhang
Yang Li
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: Archives of Dermatological Research / Issue 7/2016
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-016-1663-6

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iRhom2 ^Uncv mutation blocks bulge stem cells assuming the fate of hair follicle

Abstract

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