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International Journal of Hematology
Published in: International Journal of Hematology 6/2018

01-12-2018 | Case Report

Invasive Scopulariopsis alboflavescens infection in patient with acute myeloid leukemia

Authors: Keiji Kurata, Sho Nishimura, Hiroya Ichikawa, Rina Sakai, Yu Mizutani, Kei Takenaka, Seiji Kakiuchi, Yoshiharu Miyata, Akihito Kitao, Kimikazu Yakushijin, Shinichiro Kawamoto, Katsuya Yamamoto, Mitsuhiro Ito, Hiroshi Matsuoka, Issei Tokimatsu, Katsuhiko Kamei, Hironobu Minami

Published in: International Journal of Hematology | Issue 6/2018

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Abstract

Scopulariopsis alboflavescens is a soil saprophyte that is widely distributed in nature. Recently, there have been increasing number of reports of invasive infections with Scopulariopsis species in immunocompromised patients. In this report, we described an adult woman with acute myeloid leukemia and who developed S. alboflavescens pneumonia. Liposomal amphotericin B and voriconazole combination therapy was unsuccessful and the patient died because of pneumonia. Scopulariopsis is highly resistant to available antifungal agents and almost invariably fatal. This case report should alert clinicians to the importance of listing Scopulariopsis as a pathogenic fungus in immunocompromised patients.
Literature
1.
Tosti A, Piraccini BM, Stinchi C, Lorenzi S. Onychomycosis due to Scopulariopsis brevicaulis: clinical features and response to systemic antifungals. Br J Dermatol. 1996;135:799–802.CrossRef
2.
Tosti A, Piraccini BM, Lorenzi S. Onychomycosis caused by nondermatophytic molds: clinical features and response to treatment of 59 cases. J Am Acad Dermatol. 2000;42:217–24.CrossRef
3.
Iwen PC, Schutte SD, Florescu DF, Noel-Hurst RK, Sigler L. Invasive Scopulariopsis brevicaulis infection in an immunocompromised patient and review of prior cases caused by Scopulariopsis and Microascus species. Med Mycol. 2012;50:561–9.CrossRef
4.
Rossier C, Hoang-Van K, Turian G. Secretion of an Mr 60000 protein by benomyl-treated cells of Neurospora crassa. Eur J Cell Biol. 1989;50:333–9.PubMed
5.
Lai CC, Tan CK, Huang YT, Shao PL, Hsueh PR. Current challenges in the management of invasive fungal infections. J Infect Chemother. 2008;14:77–85.CrossRef
6.
Walsh TJ, Groll A, Hiemenz J, Fleming R, Roilides E, Anaissie E. Infections due to emerging and uncommon medically important fungal pathogens. Clin Microbiol Infect. 2004;10(Suppl 1):48–66.CrossRef
7.
Li XL, Ojaghian MR, Zhang JZ, Zhu SJ. A new species of Scopulariopsis and its synergistic effect on pathogenicity of Verticillium dahliae on cotton plants. Microbiol Res. 2017;201:12–20.CrossRef
8.
Yang Q, Wei J, Chen Z. Fatal bronchial invasion of Scopulariopsis brevicaulis in an acute monocytic leukemia patient. Diagn Microbiol Infect Dis. 2012;73:369–71.CrossRef
9.
Petit A, Levine E, Epaud R, Le Pointe HD, Angoulvant A. Scopulariopsis brevicaulis abscess in a child treated for myeloblastic leukaemia. Lancet Infect Dis. 2011;11:416.CrossRef
10.
Kriesel JD, Adderson EE, Gooch WM III, Pavia AT. Invasive sinonasal disease due to Scopulariopsis candida: case report and review of scopulariopsosis. Clin Infect Dis. 1994;19:317–9.CrossRef
11.
Pate MJ, Hemmige V, Woc-Colburn L, Restrepo A. Successful eradication of invasive Scopulariopsis brumptii in a liver transplant recipient. Transpl Infect Dis. 2016;18:275–9.CrossRef
12.
Neglia JP, Hurd DD, Ferrieri P, Snover DC. Invasive Scopulariopsis in the immunocompromised host. Am J Med. 1987;83:1163–6.CrossRef
13.
Krisher KK, Holdridge NB, Mustafa MM, Rinaldi MG, McGough DA. Disseminated Microascus cirrosus infection in pediatric bone marrow transplant recipient. J Clin Microbiol. 1995;33:735–7.PubMedPubMedCentral
14.
Ellison MD, Hung RT, Harris K, Campbell BH. Report of the first case of invasive fungal sinusitis caused by Scopulariopsis acremonium: review of scopulariopsis infections. Arch Otolaryngol Head Neck Surg. 1998;124:1014–6.CrossRef
15.
Swick BL, Reddy SC, Friedrichs A, Stone MS. Disseminated Scopulariopsis-culture is required to distinguish from other disseminated mould infections. J Cutan Pathol. 2010;37:687–91.CrossRef
16.
Steinbach WJ, Schell WA, Miller JL, Perfect JR, Martin PL. Fatal Scopulariopsis brevicaulis infection in a paediatric stem-cell transplant patient treated with voriconazole and caspofungin and a review of Scopulariopsis infections in immunocompromised patients. J Infect. 2004;48:112–6.CrossRef
17.
Ustun C, Huls G, Stewart M, Marr KA. Resistant Microascus cirrosus pneumonia can be treated with a combination of surgery, multiple anti-fungal agents and a growth factor. Mycopathologia. 2006;162:299–302.CrossRef
18.
Beltrame A, Sarmati L, Cudillo L, Cerretti R, Picardi A, Anemona L, et al. A fatal case of invasive fungal sinusitis by Scopulariopsis acremonium in a bone marrow transplant recipient. Int J Infect Dis. 2009;13:e488-92.CrossRef
19.
Salmon A, Debourgogne A, Vasbien M, Clement L, Collomb J, Plenat F, et al. Disseminated Scopulariopsis brevicaulis infection in an allogeneic stem cell recipient: case report and review of the literature. Clin Microbiol Infect. 2010;16:508–12.CrossRef
20.
Szental JA, Kam JK, Yohendran J, Morrissey O, Hall AJ. Presumed Scopulariopsis brevicaulis chorioretinitis in a stem cell transplant recipient. Clin Exp Ophthalmol. 2010;38:314–5.PubMed
21.
Gavril D, Woerther PL, Ben Lakhdar A, Mahjoubi L, Routier E, Chachaty E, et al. Invasive cutaneous infection due to Scopulariopsis brevicaulis unsuccessfully treated with high-dose micafungin in a neutropenic patient. Infection. 2017;45:361–3.CrossRef
22.
Jain D, Oberoi JK, Shahi SK, Shivnani G, Wattal C. Scopulariopsis brevicaulis infection of prosthetic valve resembling aspergilloma on histopathology. Cardiovasc Pathol. 2011;20:381–3.CrossRef
23.
Odabasi Z, Paetznick VL, Rodriguez JR, Chen E, McGinnis MR, Ostrosky-Zeichner L. Differences in beta-glucan levels in culture supernatants of a variety of fungi. Med Mycol. 2006;44:267–72.CrossRef
24.
Sandoval-Denis M, Sutton DA, Fothergill AW, Cano-Lira J, Gene J, Decock CA, et al. Scopulariopsis, a poorly known opportunistic fungus: spectrum of species in clinical samples and in vitro responses to antifungal drugs. J Clin Microbiol. 2013;51:3937–43.CrossRef
25.
Cuenca-Estrella M, Gomez-Lopez A, Buitrago MJ, Mellado E, Garcia-Effron G, Rodriguez-Tudela JL. In vitro activities of 10 combinations of antifungal agents against the multiresistant pathogen Scopulariopsis brevicaulis. Antimicrob Agents Chemother. 2006;50:2248–50.CrossRef
26.
Yao L, Wan Z, Li R, Yu J. In vitro triple combination of antifungal drugs against clinical Scopulariopsis and Microascus species. Antimicrob Agents Chemother. 2015;59:5040–3.CrossRef
27.
Martin-Vicente A, Guarro J, Capilla J. Does a triple combination have better activity than double combinations against multiresistant fungi? Experimental in vitro evaluation. Int J Antimicrob Agents. 2017;49:422–6.CrossRef
28.
Woudenberg JHC, Meijer M, Houbraken J, Samson RA. Scopulariopsis and scopulariopsis-like species from indoor environments. Stud Mycol. 2017;88:1–35.CrossRef
Metadata
Title
Invasive Scopulariopsis alboflavescens infection in patient with acute myeloid leukemia
Authors
Keiji Kurata
Sho Nishimura
Hiroya Ichikawa
Rina Sakai
Yu Mizutani
Kei Takenaka
Seiji Kakiuchi
Yoshiharu Miyata
Akihito Kitao
Kimikazu Yakushijin
Shinichiro Kawamoto
Katsuya Yamamoto
Mitsuhiro Ito
Hiroshi Matsuoka
Issei Tokimatsu
Katsuhiko Kamei
Hironobu Minami
Publication date
01-12-2018
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 6/2018
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-018-2496-1

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