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Published in: Trials 1/2022

Open Access 01-12-2022 | Study protocol

Introducing insect- or plant-based dinner meals to families in Denmark: study protocol for a randomized intervention trial

Authors: Cassandra Maya, Luís Miguel Cunha, Ana Isabel de Almeida Costa, Teun Veldkamp, Nanna Roos

Published in: Trials | Issue 1/2022

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Abstract

Background

Plant- and insect-based foods are promising alternative protein sources. Previous studies have shown that introducing plant-based foods to the diet can reduce meat intake, but no such intervention has explored the effects of insect-based foods.

Methods

This study aims to integrate alternative proteins to main meals of 80 Danish families through a 6-week two-arm randomized intervention trial to investigate acceptance, consumption, and potential for meat replacement. The primary outcome is the replacement of dietary meat protein with plant- or insect-based protein from the intervention foods assessed through change in daily meat protein intake, proportion of meat protein to total protein intake, and counts of dinner meals with meat and intervention products.

Conclusion

The results of this study will contribute to research in alternative proteins and explore the effects of long-term exposure of meat replacement.

Trial registration

ClinicalTrials.gov: NCT05156853. Registered 24 December 2021
Literature
1.
go back to reference Wood A, Gordon LJ, Röös E, Karlsson J, Häyhä T, Bignet V, et al. Nordic food systems for improved health and sustainability: baseline assessment to inform transformation [Internet]. Stockholm: Stockholm Resilience Centre; 2019. Available from: http://www.stockholmresilience.org Wood A, Gordon LJ, Röös E, Karlsson J, Häyhä T, Bignet V, et al. Nordic food systems for improved health and sustainability: baseline assessment to inform transformation [Internet]. Stockholm: Stockholm Resilience Centre; 2019. Available from: http://​www.​stockholmresilie​nce.​org
4.
go back to reference IPCC. Summary for Policymakers. In: Shukla PR, Skea J, Slade R, Al Khourdajie A, van Diemen R, McCollum D, Pathak M, Some S, Vyas P, Fradera R, Belkacemi M, Hasija A, Lisboa G, Luz S, Malley J, editors. Climate Change 2022: Mitigation of Climate Change Contribution of Working Group III to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change. Cambridge, New York: Cambridge University Press; 2022. Available from. https://doi.org/10.1017/9781009157926.001.CrossRef IPCC. Summary for Policymakers. In: Shukla PR, Skea J, Slade R, Al Khourdajie A, van Diemen R, McCollum D, Pathak M, Some S, Vyas P, Fradera R, Belkacemi M, Hasija A, Lisboa G, Luz S, Malley J, editors. Climate Change 2022: Mitigation of Climate Change Contribution of Working Group III to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change. Cambridge, New York: Cambridge University Press; 2022. Available from. https://​doi.​org/​10.​1017/​9781009157926.​001.CrossRef
6.
go back to reference Lassen AD, Christensen LM, Trolle E. Development of a Danish adapted healthy plant-based diet based on the EAT-Lancet Reference Diet. Nutrients. 2020;12(3):738.CrossRef Lassen AD, Christensen LM, Trolle E. Development of a Danish adapted healthy plant-based diet based on the EAT-Lancet Reference Diet. Nutrients. 2020;12(3):738.CrossRef
8.
go back to reference EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Castenmiller J, De Henauw S, Hirsch-Ernst KI, Kearney J, et al. Safety of dried yellow mealworm (Tenebrio molitor larva) as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2021;19(1):e06343.CrossRef EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Castenmiller J, De Henauw S, Hirsch-Ernst KI, Kearney J, et al. Safety of dried yellow mealworm (Tenebrio molitor larva) as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2021;19(1):e06343.CrossRef
9.
go back to reference EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Castenmiller J, De Henauw S, Hirsch-Ernst KI, et al. Safety of frozen and dried formulations from whole yellow mealworm (Tenebrio molitor larva) as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2021;19(8):e06778. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Castenmiller J, De Henauw S, Hirsch-Ernst KI, et al. Safety of frozen and dried formulations from whole yellow mealworm (Tenebrio molitor larva) as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2021;19(8):e06778.
10.
go back to reference EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Castenmiller J, De Henauw S, Hirsch-Ernst KI, et al. Safety of frozen and freeze-dried formulations of the lesser mealworm (Alphitobius diaperinus larva) as a Novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2022;20(7):e07325.CrossRef EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Castenmiller J, De Henauw S, Hirsch-Ernst KI, et al. Safety of frozen and freeze-dried formulations of the lesser mealworm (Alphitobius diaperinus larva) as a Novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2022;20(7):e07325.CrossRef
11.
go back to reference EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Castenmiller J, De Henauw S, Hirsch-Ernst KI, et al. Safety of frozen and dried formulations from whole house crickets (Acheta domesticus) as a Novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2021;19(8):e06779. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Castenmiller J, De Henauw S, Hirsch-Ernst KI, et al. Safety of frozen and dried formulations from whole house crickets (Acheta domesticus) as a Novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2021;19(8):e06779.
12.
go back to reference EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Castenmiller J, De Henauw S, Hirsch-Ernst KI, et al. Safety of partially defatted house cricket (Acheta domesticus) powder as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2022;20(5):e07258. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Castenmiller J, De Henauw S, Hirsch-Ernst KI, et al. Safety of partially defatted house cricket (Acheta domesticus) powder as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2022;20(5):e07258.
13.
go back to reference van Huis A, Rumpold B, Maya C, Roos N. Nutritional qualities and enhancement of edible insects. Annu Rev Nutr. 2021;41:551–76.CrossRef van Huis A, Rumpold B, Maya C, Roos N. Nutritional qualities and enhancement of edible insects. Annu Rev Nutr. 2021;41:551–76.CrossRef
14.
go back to reference Roos N. Insects and human nutrition. In: Edible Insects in Sustainable Food Systems. Cham: Springer; 2018. p. 83–91. Roos N. Insects and human nutrition. In: Edible Insects in Sustainable Food Systems. Cham: Springer; 2018. p. 83–91.
15.
go back to reference Malla N, Nørgaard JV, Lærke HN, Heckmann LHL, Roos N. Some insect species are good-quality protein sources for children and adults: digestible indispensable amino acid score (DIAAS) determined in growing pigs. J Nutr. 2022;152(4):1042–51.CrossRef Malla N, Nørgaard JV, Lærke HN, Heckmann LHL, Roos N. Some insect species are good-quality protein sources for children and adults: digestible indispensable amino acid score (DIAAS) determined in growing pigs. J Nutr. 2022;152(4):1042–51.CrossRef
16.
go back to reference Halloran A, Roos N, Eilenberg J, Cerutti A, Bruun S. Life cycle assessment of edible insects for food protein: a review. Agron Sustain Dev. 2016;36(4):57.CrossRef Halloran A, Roos N, Eilenberg J, Cerutti A, Bruun S. Life cycle assessment of edible insects for food protein: a review. Agron Sustain Dev. 2016;36(4):57.CrossRef
17.
go back to reference Halloran A, Roos N, Hanboonsong Y. Cricket farming as a livelihood strategy in Thailand. Geogr J. 2017;183(1):112–24.CrossRef Halloran A, Roos N, Hanboonsong Y. Cricket farming as a livelihood strategy in Thailand. Geogr J. 2017;183(1):112–24.CrossRef
18.
go back to reference van Broekhoven S, Oonincx DGAB, van Huis A, van Loon JJA. Growth performance and feed conversion efficiency of three edible mealworm species (Coleoptera: Tenebrionidae) on diets composed of organic by-products. J Insect Physiol. 2015;73:1–10.CrossRef van Broekhoven S, Oonincx DGAB, van Huis A, van Loon JJA. Growth performance and feed conversion efficiency of three edible mealworm species (Coleoptera: Tenebrionidae) on diets composed of organic by-products. J Insect Physiol. 2015;73:1–10.CrossRef
19.
go back to reference Oonincx DGAB, van Huis A, van Loon JJA. Nutrient utilisation by black soldier flies fed with chicken, pig, or cow manure. J Insects Food Feed. 2015;1(2):131–9.CrossRef Oonincx DGAB, van Huis A, van Loon JJA. Nutrient utilisation by black soldier flies fed with chicken, pig, or cow manure. J Insects Food Feed. 2015;1(2):131–9.CrossRef
20.
go back to reference Van Huis A, Van Itterbeeck J, Klunder H, Mertens E, Halloran A, Muir G, et al. Edible insects: future prospects for food and feed security: Food and agriculture organization of the United Nations; 2013. Van Huis A, Van Itterbeeck J, Klunder H, Mertens E, Halloran A, Muir G, et al. Edible insects: future prospects for food and feed security: Food and agriculture organization of the United Nations; 2013.
21.
go back to reference Evans J, Alemu M h, Flore R, Frøst M b, Halloran A, Jensen A b, et al. ‘Entomophagy’: an evolving terminology in need of review. J Insects Food Feed. 2015;1(4):293–305.CrossRef Evans J, Alemu M h, Flore R, Frøst M b, Halloran A, Jensen A b, et al. ‘Entomophagy’: an evolving terminology in need of review. J Insects Food Feed. 2015;1(4):293–305.CrossRef
22.
go back to reference Tan HSG, Fischer ARH, Tinchan P, Stieger M, Steenbekkers LPA, van Trijp HCM. Insects as food: Exploring cultural exposure and individual experience as determinants of acceptance. Food Qual Prefer. 2015;42:78–89.CrossRef Tan HSG, Fischer ARH, Tinchan P, Stieger M, Steenbekkers LPA, van Trijp HCM. Insects as food: Exploring cultural exposure and individual experience as determinants of acceptance. Food Qual Prefer. 2015;42:78–89.CrossRef
23.
go back to reference House J. Insects are not ‘the new sushi’: theories of practice and the acceptance of novel foods. Soc Cult Geogr. 2019;20(9):1285–306.CrossRef House J. Insects are not ‘the new sushi’: theories of practice and the acceptance of novel foods. Soc Cult Geogr. 2019;20(9):1285–306.CrossRef
24.
go back to reference Ribeiro JC, Gonçalves ATS, Moura AP, Varela P, Cunha LM. Insects as food and feed in Portugal and Norway – cross-cultural comparison of determinants of acceptance. Food Qual Prefer. 2022;102:104650.CrossRef Ribeiro JC, Gonçalves ATS, Moura AP, Varela P, Cunha LM. Insects as food and feed in Portugal and Norway – cross-cultural comparison of determinants of acceptance. Food Qual Prefer. 2022;102:104650.CrossRef
25.
go back to reference Onwezen MC, Bouwman EP, Reinders MJ, Dagevos H. A systematic review on consumer acceptance of alternative proteins: pulses, algae, insects, plant-based meat alternatives, and cultured meat. Appetite. 2021;159:105058.CrossRef Onwezen MC, Bouwman EP, Reinders MJ, Dagevos H. A systematic review on consumer acceptance of alternative proteins: pulses, algae, insects, plant-based meat alternatives, and cultured meat. Appetite. 2021;159:105058.CrossRef
26.
go back to reference Kröger T, Dupont J, Büsing L, Fiebelkorn F. Acceptance of insect-based food products in western societies: a systematic review. Front Nutr. 2022;8(759885):1186. Kröger T, Dupont J, Büsing L, Fiebelkorn F. Acceptance of insect-based food products in western societies: a systematic review. Front Nutr. 2022;8(759885):1186.
27.
go back to reference Woolf E, Zhu Y, Emory K, Zhao J, Liu C. Willingness to consume insect-containing foods: a survey in the United States. LWT. 2019;102:100–5.CrossRef Woolf E, Zhu Y, Emory K, Zhao J, Liu C. Willingness to consume insect-containing foods: a survey in the United States. LWT. 2019;102:100–5.CrossRef
28.
go back to reference Verbeke W. Profiling consumers who are ready to adopt insects as a meat substitute in a Western society. Food Qual Prefer. 2015;39:147–55.CrossRef Verbeke W. Profiling consumers who are ready to adopt insects as a meat substitute in a Western society. Food Qual Prefer. 2015;39:147–55.CrossRef
29.
go back to reference Dagevos H. A literature review of consumer research on edible insects: recent evidence and new vistas from 2019 studies. J Insects Food Feed. 2021;7(3):249–59.CrossRef Dagevos H. A literature review of consumer research on edible insects: recent evidence and new vistas from 2019 studies. J Insects Food Feed. 2021;7(3):249–59.CrossRef
30.
go back to reference House J. Consumer acceptance of insect-based foods in the Netherlands: academic and commercial implications. Appetite. 2016;107:47–58.CrossRef House J. Consumer acceptance of insect-based foods in the Netherlands: academic and commercial implications. Appetite. 2016;107:47–58.CrossRef
31.
go back to reference Hamerman EJ. Cooking and disgust sensitivity influence preference for attending insect-based food events. Appetite. 2016;96:319–26.CrossRef Hamerman EJ. Cooking and disgust sensitivity influence preference for attending insect-based food events. Appetite. 2016;96:319–26.CrossRef
32.
go back to reference Nyberg M, Olsson V, Wendin K. ‘Would you like to eat an insect?’—Children’s perceptions of and thoughts about eating insects. Int J Consum Stud. 2021;45(2):248–58.CrossRef Nyberg M, Olsson V, Wendin K. ‘Would you like to eat an insect?’—Children’s perceptions of and thoughts about eating insects. Int J Consum Stud. 2021;45(2):248–58.CrossRef
33.
go back to reference Brynning G, Bækgaard JU, Heckmann LHL. Investigation of consumer acceptance of foods containing insects and development of non-snack insect-based foods. Ind Biotechnol. 2020;16(1):26–32.CrossRef Brynning G, Bækgaard JU, Heckmann LHL. Investigation of consumer acceptance of foods containing insects and development of non-snack insect-based foods. Ind Biotechnol. 2020;16(1):26–32.CrossRef
34.
go back to reference Woolf E, Maya C, Yoon J, Shertukde S, Toia T, Zhao J, et al. Information and taste interventions for improving consumer acceptance of edible insects: a pilot study. J Insects Food Feed. 2021;7(2):129–39.CrossRef Woolf E, Maya C, Yoon J, Shertukde S, Toia T, Zhao J, et al. Information and taste interventions for improving consumer acceptance of edible insects: a pilot study. J Insects Food Feed. 2021;7(2):129–39.CrossRef
35.
go back to reference Ribeiro JC, Lima RC, Maia MRG, Almeida AA, Fonseca AJM, Cabrita ARJ, et al. Impact of defatting freeze-dried edible crickets (Acheta domesticus and Gryllodes sigillatus) on the nutritive value, overall liking and sensory profile of cereal bars. LWT. 2019;113:108335.CrossRef Ribeiro JC, Lima RC, Maia MRG, Almeida AA, Fonseca AJM, Cabrita ARJ, et al. Impact of defatting freeze-dried edible crickets (Acheta domesticus and Gryllodes sigillatus) on the nutritive value, overall liking and sensory profile of cereal bars. LWT. 2019;113:108335.CrossRef
36.
go back to reference Macdiarmid JI, Douglas F, Campbell J. Eating like there’s no tomorrow: public awareness of the environmental impact of food and reluctance to eat less meat as part of a sustainable diet. Appetite. 2016;96:487–93.CrossRef Macdiarmid JI, Douglas F, Campbell J. Eating like there’s no tomorrow: public awareness of the environmental impact of food and reluctance to eat less meat as part of a sustainable diet. Appetite. 2016;96:487–93.CrossRef
37.
go back to reference Possidónio C, Prada M, Graça J, Piazza J. Consumer perceptions of conventional and alternative protein sources: a mixed-methods approach with meal and product framing. Appetite. 2021;156(August 2020). Possidónio C, Prada M, Graça J, Piazza J. Consumer perceptions of conventional and alternative protein sources: a mixed-methods approach with meal and product framing. Appetite. 2021;156(August 2020).
38.
go back to reference Holloway T, Salter AM, McCullough FS. Dietary intervention to reduce meat intake by 50% in University students – a pilot study. Proc Nutr Soc. Cambridge University Press. 2012;71(OCE2):E164.CrossRef Holloway T, Salter AM, McCullough FS. Dietary intervention to reduce meat intake by 50% in University students – a pilot study. Proc Nutr Soc. Cambridge University Press. 2012;71(OCE2):E164.CrossRef
39.
go back to reference Bianchi F, Stewart C, Astbury NM, Cook B, Aveyard P, Jebb SA. Replacing meat with alternative plant-based products (RE-MAP): a randomized controlled trial of a multicomponent behavioral intervention to reduce meat consumption. Am J Clin Nutr. 2022;115(5):1357–66.CrossRef Bianchi F, Stewart C, Astbury NM, Cook B, Aveyard P, Jebb SA. Replacing meat with alternative plant-based products (RE-MAP): a randomized controlled trial of a multicomponent behavioral intervention to reduce meat consumption. Am J Clin Nutr. 2022;115(5):1357–66.CrossRef
40.
go back to reference Graça J, Godinho CA, Truninger M. Reducing meat consumption and following plant-based diets: current evidence and future directions to inform integrated transitions. Trends Food Sci Technol. 2019;91:380–90.CrossRef Graça J, Godinho CA, Truninger M. Reducing meat consumption and following plant-based diets: current evidence and future directions to inform integrated transitions. Trends Food Sci Technol. 2019;91:380–90.CrossRef
41.
go back to reference Caparros Megido R, Gierts C, Blecker C, Brostaux Y, Haubruge É, Alabi T, et al. Consumer acceptance of insect-based alternative meat products in Western countries. Food Qual Prefer. 2016;52:237–43.CrossRef Caparros Megido R, Gierts C, Blecker C, Brostaux Y, Haubruge É, Alabi T, et al. Consumer acceptance of insect-based alternative meat products in Western countries. Food Qual Prefer. 2016;52:237–43.CrossRef
42.
go back to reference Kinyuru J, Kipkoech C, Imathiu S, Konyole S, Roos N. Acceptability of cereal-cricket porridge compared to cereal and cereal-milk- porridges among caregivers and nursery school children in Uasin Gishu. Kenya. Int J Trop Insect Sci. 2021;41(3):2007–13.CrossRef Kinyuru J, Kipkoech C, Imathiu S, Konyole S, Roos N. Acceptability of cereal-cricket porridge compared to cereal and cereal-milk- porridges among caregivers and nursery school children in Uasin Gishu. Kenya. Int J Trop Insect Sci. 2021;41(3):2007–13.CrossRef
43.
go back to reference Pedersen AN, Christensen T, Matthiessen J, Knudsen VK, Rosenlund-Sørensen M, Biltoft-Jensen A, et al. Dietary habits in Denmark 2011-2013. Main results: Danish Technical University; 2015. Available from: http://www.food.dtu.dk Pedersen AN, Christensen T, Matthiessen J, Knudsen VK, Rosenlund-Sørensen M, Biltoft-Jensen A, et al. Dietary habits in Denmark 2011-2013. Main results: Danish Technical University; 2015. Available from: http://​www.​food.​dtu.​dk
44.
go back to reference Pali-Schöll I, Meinlschmidt P, Larenas-Linnemann D, Purschke B, Hofstetter G, Rodríguez-Monroy FA, et al. Edible insects: cross-recognition of IgE from crustacean- and house dust mite allergic patients, and reduction of allergenicity by food processing. World Allergy Organ J. 2019;12(1):100006.CrossRef Pali-Schöll I, Meinlschmidt P, Larenas-Linnemann D, Purschke B, Hofstetter G, Rodríguez-Monroy FA, et al. Edible insects: cross-recognition of IgE from crustacean- and house dust mite allergic patients, and reduction of allergenicity by food processing. World Allergy Organ J. 2019;12(1):100006.CrossRef
45.
go back to reference Ribeiro JC, Sousa-Pinto B, Fonseca J, Fonseca SC, Cunha LM. Edible insects and food safety: allergy. J Insects Food Feed. 2021;7(5):833–47.CrossRef Ribeiro JC, Sousa-Pinto B, Fonseca J, Fonseca SC, Cunha LM. Edible insects and food safety: allergy. J Insects Food Feed. 2021;7(5):833–47.CrossRef
46.
go back to reference Pliner P, Hobden K. Development of a scale to measure the trait of food neophobia in humans. Appetite. 1992;19(2):105–20.CrossRef Pliner P, Hobden K. Development of a scale to measure the trait of food neophobia in humans. Appetite. 1992;19(2):105–20.CrossRef
47.
go back to reference Pliner P. Development of measures of food neophobia in children. Appetite. 1994;23(2):147–63.CrossRef Pliner P. Development of measures of food neophobia in children. Appetite. 1994;23(2):147–63.CrossRef
48.
go back to reference Damsbo-Svendsen M, Frøst MB, Olsen A. Development of novel tools to measure food neophobia in children. Appetite. 2017;113:255–63.CrossRef Damsbo-Svendsen M, Frøst MB, Olsen A. Development of novel tools to measure food neophobia in children. Appetite. 2017;113:255–63.CrossRef
49.
go back to reference Hartmann C, Siegrist M. Development and validation of the Food Disgust Scale. Food Qual Prefer. 2018;63(July 2017):38–50.CrossRef Hartmann C, Siegrist M. Development and validation of the Food Disgust Scale. Food Qual Prefer. 2018;63(July 2017):38–50.CrossRef
50.
go back to reference Rozin P, Chan CM, Ruby MB. Getting people to eat more insects. In: Summary Report. 1st International Conference: Insects to Feed the World. 2014 May 14-17. the Netherlands: FAO and Wageningen University; 2014. p. 80. Rozin P, Chan CM, Ruby MB. Getting people to eat more insects. In: Summary Report. 1st International Conference: Insects to Feed the World. 2014 May 14-17. the Netherlands: FAO and Wageningen University; 2014. p. 80.
51.
go back to reference Graça J, Calheiros MM, Oliveira A. Attached to meat? (Un)Willingness and intentions to adopt a more plant-based diet. Appetite. 2015;95:113–25.CrossRef Graça J, Calheiros MM, Oliveira A. Attached to meat? (Un)Willingness and intentions to adopt a more plant-based diet. Appetite. 2015;95:113–25.CrossRef
52.
go back to reference Yuan X, Murakami K, Asakura K, Uechi K, Masayasu S, Sasaki S. Formulas developed based on the ratio of urea nitrogen to creatinine concentrations obtained from multiple spot urine samples are acceptable to predict protein intake at group level but not at individual level. Nutr Res N Y N. 2020;78:50–9.CrossRef Yuan X, Murakami K, Asakura K, Uechi K, Masayasu S, Sasaki S. Formulas developed based on the ratio of urea nitrogen to creatinine concentrations obtained from multiple spot urine samples are acceptable to predict protein intake at group level but not at individual level. Nutr Res N Y N. 2020;78:50–9.CrossRef
53.
go back to reference Imathiu S. Benefits and food safety concerns associated with consumption of edible insects. NFS J. 2020;18:1–11.CrossRef Imathiu S. Benefits and food safety concerns associated with consumption of edible insects. NFS J. 2020;18:1–11.CrossRef
Metadata
Title
Introducing insect- or plant-based dinner meals to families in Denmark: study protocol for a randomized intervention trial
Authors
Cassandra Maya
Luís Miguel Cunha
Ana Isabel de Almeida Costa
Teun Veldkamp
Nanna Roos
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Trials / Issue 1/2022
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-022-07000-6

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