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01-12-2013 | Scientific Article

Intraosseous schwannoma in schwannomatosis

Authors: T. G. Kashima, M. R. J. P. Gibbons, D. Whitwell, C. L. M. H. Gibbons, K. M. Bradley, S. J. Ostlere, N. A. Athanasou

Published in: Skeletal Radiology | Issue 12/2013

Abstract

This study investigates the clinical, radiological, and pathological features of two cases of intraosseous schwannoma that arose in patients with multiple soft tissue schwannomas. In both cases, the patients were adult females and the tibial bone was affected. Vestibular schwannomas were not identified, indicating that these were not cases of neurofibromatosis 2 (NF2). Radiographs showed a well-defined lytic lesion in the proximal tibia; in one case, this was associated with a pathological fracture. Histologically, both cases showed typical features of benign schwannoma. Molecular analysis of one of the excised tumors showed different alterations in the NF2 gene in keeping with a diagnosis of schwannomatosis. Our findings show for the first time that intraosseous schwannomas can occur in schwannomatosis.

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Title: Intraosseous schwannoma in schwannomatosis
Authors: T. G. Kashima
M. R. J. P. Gibbons
D. Whitwell
C. L. M. H. Gibbons
K. M. Bradley
S. J. Ostlere
N. A. Athanasou
Publication date: 01-12-2013
Publisher: Springer Berlin Heidelberg
Published in: Skeletal Radiology / Issue 12/2013
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI: https://doi.org/10.1007/s00256-013-1712-6

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Intraosseous schwannoma in schwannomatosis

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