Skip to main content
Top
Published in: World Journal of Surgical Oncology 1/2016

Open Access 01-12-2016 | Research

Intraoperative indocyanine green fluorescence guidance for excision of nonpalpable breast cancer

Authors: Jintao Liu, Wenbin Guo, Meng Tong

Published in: World Journal of Surgical Oncology | Issue 1/2016

Login to get access

Abstract

Background

Different techniques have been used for the guidance of nonpalpable breast cancer (NBC), but none of them has yet achieved perfect results. The aim of this study was to evaluate the feasibility of indocyanine green (ICG) fluorescence-guided nonpalpable breast cancer lesion excision (IFNLE), to introduce an alternative technique.

Methods

The data about 56 patients with preoperatively diagnosed NBCs operated with the help of intraoperative IFNLE between November of 2010 and September of 2014 were retrospectively analyzed.

Results

ICG fluorescence localized all lesions at surgery. Re-excision due to positive resection margins was necessary in two patients (3.6 %; 2/56) with ductal carcinoma in situ (DCIS) at the surgical margins. Mastectomy was necessary in one patient (1.8 %; 1/56) due to multifocal invasive carcinoma. The mean volume of the excised tissue was 38.2 ± 16.5 cm3.

Conclusions

IFNLE is a technically applicable and clinically acceptable procedure whenever a breast cancer needs image-guided excision.
Literature
1.
go back to reference Tabar L, Dean PB, Kaufman CS, Duffy SW, Chen HH. A new era in the diagnosis of breast cancer. Surg Oncol Clin North Am. 2000;9:233–7. Tabar L, Dean PB, Kaufman CS, Duffy SW, Chen HH. A new era in the diagnosis of breast cancer. Surg Oncol Clin North Am. 2000;9:233–7.
2.
go back to reference Kaufman CS, Jacobson L, Bachman B, Kaufman LBS. Intraoperative ultrasound facilitates surgery for early breast cancer. Ann Surg Oncol. 2002;9:988–93.CrossRefPubMed Kaufman CS, Jacobson L, Bachman B, Kaufman LBS. Intraoperative ultrasound facilitates surgery for early breast cancer. Ann Surg Oncol. 2002;9:988–93.CrossRefPubMed
3.
go back to reference Fortunato L, Penteriani R, Farina M, Vitelli CE, Piro FR. Intraoperative ultrasound is an effective and preferable technique to localization of nonpalpable breast tumors. Eur J Surg Oncol. 2008;34:1289–92.CrossRefPubMed Fortunato L, Penteriani R, Farina M, Vitelli CE, Piro FR. Intraoperative ultrasound is an effective and preferable technique to localization of nonpalpable breast tumors. Eur J Surg Oncol. 2008;34:1289–92.CrossRefPubMed
4.
go back to reference Inui H, Watatani M, Hashimoto Y, Hojo T, Hirai K, Yamato M, et al. Hematoma-directed and ultrasound-guided breast-conserving surgery for nonpalpable breast cancer after mammotome biopsy. Surg Today. 2008;38:279–82.CrossRefPubMed Inui H, Watatani M, Hashimoto Y, Hojo T, Hirai K, Yamato M, et al. Hematoma-directed and ultrasound-guided breast-conserving surgery for nonpalpable breast cancer after mammotome biopsy. Surg Today. 2008;38:279–82.CrossRefPubMed
5.
go back to reference Aydogan F, Ozben V, Celik V, Uras C, Tahan G, Gazioglu E, et al. Radioguided occult lesion localization for non-palpable breast cancer: a comparison between day-before and same-day protocols. Breast. 2010;19:226–30.CrossRefPubMed Aydogan F, Ozben V, Celik V, Uras C, Tahan G, Gazioglu E, et al. Radioguided occult lesion localization for non-palpable breast cancer: a comparison between day-before and same-day protocols. Breast. 2010;19:226–30.CrossRefPubMed
6.
go back to reference Van der Ploeg IM, Hobbelink M, Van den Bosch MA, Mali WP, Borel Rinkes IH, Van Hillegersberg R. Radioguided occult lesion localization for non-palpable breast lesions: a review of the relevant literature. Eur J Surg Oncol. 2008;34:1–5.CrossRefPubMed Van der Ploeg IM, Hobbelink M, Van den Bosch MA, Mali WP, Borel Rinkes IH, Van Hillegersberg R. Radioguided occult lesion localization for non-palpable breast lesions: a review of the relevant literature. Eur J Surg Oncol. 2008;34:1–5.CrossRefPubMed
7.
go back to reference Wilson M, Boggis CR, Mansel RE, Harland RNL. Non-invasive ultrasound localization of impalpable breast lesions. Clin Radiol. 1993;47:337–8.CrossRefPubMed Wilson M, Boggis CR, Mansel RE, Harland RNL. Non-invasive ultrasound localization of impalpable breast lesions. Clin Radiol. 1993;47:337–8.CrossRefPubMed
8.
go back to reference Guo WB, Zhang L, Ji J, Gao W, Liu JT, Tong M. Breast cancer sentinel lymph node mapping using near infrared guided indocyanine green in comparison with blue dye. Tumor Biol. 2014;35:3073–8.CrossRef Guo WB, Zhang L, Ji J, Gao W, Liu JT, Tong M. Breast cancer sentinel lymph node mapping using near infrared guided indocyanine green in comparison with blue dye. Tumor Biol. 2014;35:3073–8.CrossRef
9.
go back to reference Hojo T, Nagao T, Kikuyama M, Akashi S, Kinoshita T. Evaluation of sentinel node biopsy by combined fluorescent and dye method and lymph flow for breast cancer. Breast. 2010;19:210–3.CrossRefPubMed Hojo T, Nagao T, Kikuyama M, Akashi S, Kinoshita T. Evaluation of sentinel node biopsy by combined fluorescent and dye method and lymph flow for breast cancer. Breast. 2010;19:210–3.CrossRefPubMed
10.
go back to reference Cady B, Stone MD, Schuler JG, Thakur R, Wanner MA, Lavin PT. The new era in breast cancer: invasion, size and nodal involvement dramatically decreasing as a result of mammographic screening. Arch Surg. 1996;131:301–8.CrossRefPubMed Cady B, Stone MD, Schuler JG, Thakur R, Wanner MA, Lavin PT. The new era in breast cancer: invasion, size and nodal involvement dramatically decreasing as a result of mammographic screening. Arch Surg. 1996;131:301–8.CrossRefPubMed
11.
go back to reference Cary S, Kaufman MD, Leslie Jacobson MFT, Barbara Bachman MD, Lanuren Kaufman BS. Intraoperative ultrasound facilitates surgery for early breast cancer. Ann Sug Oncol. 2002;9:988–93.CrossRef Cary S, Kaufman MD, Leslie Jacobson MFT, Barbara Bachman MD, Lanuren Kaufman BS. Intraoperative ultrasound facilitates surgery for early breast cancer. Ann Sug Oncol. 2002;9:988–93.CrossRef
12.
go back to reference Kaufman CS, Delbecq R, Jacobson L. Excising the re-excision: stereotactic core biopsy decreases need for re-excision of breast cancer. World J Surg. 1998;22:1023–8.CrossRefPubMed Kaufman CS, Delbecq R, Jacobson L. Excising the re-excision: stereotactic core biopsy decreases need for re-excision of breast cancer. World J Surg. 1998;22:1023–8.CrossRefPubMed
13.
go back to reference Medina Franco H, Abarca Perez L, Gaecia Alvarez MN, Ulloa Gome JL, Romero Trejo C, Sepulveda Mende J. Radioguided occult lesion location (ROLL) versus wire-guided lumpectomy for nonpalpable breast lesion: a randomized prospective evaluation. J Surg Oncol. 2008;97:108–11.CrossRefPubMed Medina Franco H, Abarca Perez L, Gaecia Alvarez MN, Ulloa Gome JL, Romero Trejo C, Sepulveda Mende J. Radioguided occult lesion location (ROLL) versus wire-guided lumpectomy for nonpalpable breast lesion: a randomized prospective evaluation. J Surg Oncol. 2008;97:108–11.CrossRefPubMed
14.
go back to reference Zgajnar J, Hocevar M, Frkovic-Grazio S, Hertl K, Schweiger E, Besic N. Radioguided occult lesion localization (ROOL) of the nonpalpable breast lesions. Neoplasma. 2004;51:385–9.PubMed Zgajnar J, Hocevar M, Frkovic-Grazio S, Hertl K, Schweiger E, Besic N. Radioguided occult lesion localization (ROOL) of the nonpalpable breast lesions. Neoplasma. 2004;51:385–9.PubMed
15.
go back to reference Krekel NM, Zonderhuis BM, Stockmann HB. A comparison of three methods for nonpalpable breast cancer excision. Eur J Surg Oncol. 2011;37:109–15.CrossRefPubMed Krekel NM, Zonderhuis BM, Stockmann HB. A comparison of three methods for nonpalpable breast cancer excision. Eur J Surg Oncol. 2011;37:109–15.CrossRefPubMed
16.
go back to reference Sikošek NC, Dovnik A, Arko D, Takač I. The role of intraoperative ultrasound in breast conserving surgery of nonpalpable breast cancer. Wien Klin Wochenschr. 2014;126:90–4.CrossRefPubMed Sikošek NC, Dovnik A, Arko D, Takač I. The role of intraoperative ultrasound in breast conserving surgery of nonpalpable breast cancer. Wien Klin Wochenschr. 2014;126:90–4.CrossRefPubMed
17.
go back to reference Sheikh HEI, Abdulaziz NY. Intraoperative ultrasound localization of nonpalpable breast cancers: a valuable aid during breast-conserving surgery. Egy J Radiol Nuc. 2013;44:411–5.CrossRef Sheikh HEI, Abdulaziz NY. Intraoperative ultrasound localization of nonpalpable breast cancers: a valuable aid during breast-conserving surgery. Egy J Radiol Nuc. 2013;44:411–5.CrossRef
18.
go back to reference Barentsz MW, Dalen TA, Gobardhan PD, Bongers V, Perre CL, Pijnappel RM, et al. Intraoprative ultrasound guided for excision of non-palpable invasive breast cancer: a hospital-based series and an overview of the literature. Breast Cancer Res Treat. 2012;135:209–19.CrossRefPubMed Barentsz MW, Dalen TA, Gobardhan PD, Bongers V, Perre CL, Pijnappel RM, et al. Intraoprative ultrasound guided for excision of non-palpable invasive breast cancer: a hospital-based series and an overview of the literature. Breast Cancer Res Treat. 2012;135:209–19.CrossRefPubMed
19.
go back to reference James TA, Harlow S, Sheehey-Jones J. Intraoprative ultrasound versus mammographic needle localization for ductal carcinoma in situ. Ann Surg Oncol. 2009;16(1164):9. James TA, Harlow S, Sheehey-Jones J. Intraoprative ultrasound versus mammographic needle localization for ductal carcinoma in situ. Ann Surg Oncol. 2009;16(1164):9.
20.
go back to reference Bennett IC, Greenslade J, Chiam H. Intraoperative ultrasound-guided excision of nonpalpable breast lesion. World J Surg. 2005;29:369–74.CrossRefPubMed Bennett IC, Greenslade J, Chiam H. Intraoperative ultrasound-guided excision of nonpalpable breast lesion. World J Surg. 2005;29:369–74.CrossRefPubMed
21.
go back to reference Kang SW, Chung SE, Shin WJ, Lee JH. Polypoidal choroidal vasculopathy and late geographic hyperfluorescence on indocyanine green angiography. Br J Ophthalmol. 2009;93:759–64.CrossRefPubMed Kang SW, Chung SE, Shin WJ, Lee JH. Polypoidal choroidal vasculopathy and late geographic hyperfluorescence on indocyanine green angiography. Br J Ophthalmol. 2009;93:759–64.CrossRefPubMed
22.
23.
go back to reference Tagaya N, Yamazaki R, Nakagawa A, Abe A, Hamada K, Kubota K. Intraoperative identification of sentinel lymph nodes by near-infrared fluorescence imaging in patients with breast cancer. Am J Surg. 2008;195:850–3.CrossRefPubMed Tagaya N, Yamazaki R, Nakagawa A, Abe A, Hamada K, Kubota K. Intraoperative identification of sentinel lymph nodes by near-infrared fluorescence imaging in patients with breast cancer. Am J Surg. 2008;195:850–3.CrossRefPubMed
24.
go back to reference Hirche C, Murawa D, Mohr Z, Kneif S, Hünerbein M. ICG fluorescence-guided sentinel node biopsy for axillary nodal staging in breast cancer. Breast Cancer Res Treat. 2010;121:373–8.CrossRefPubMed Hirche C, Murawa D, Mohr Z, Kneif S, Hünerbein M. ICG fluorescence-guided sentinel node biopsy for axillary nodal staging in breast cancer. Breast Cancer Res Treat. 2010;121:373–8.CrossRefPubMed
25.
go back to reference Aydogan F, Ozben V, Aytac E, Yilmaz H, Cercel A, Celik V. Excision of nonpalpable breast cancer with indocyanine green fluorescence-guided occult lesion localization (IFOLL). Breast Care. 2012;7:48–51.CrossRefPubMedPubMedCentral Aydogan F, Ozben V, Aytac E, Yilmaz H, Cercel A, Celik V. Excision of nonpalpable breast cancer with indocyanine green fluorescence-guided occult lesion localization (IFOLL). Breast Care. 2012;7:48–51.CrossRefPubMedPubMedCentral
26.
go back to reference Luini A, Zurrida S, Paganelli G, Galimberti V, Sacchini V, Monti S, et al. Comparison of radioguided excision with wire location of occult breast lesion. Br J Surg. 1999;86:522–5.CrossRefPubMed Luini A, Zurrida S, Paganelli G, Galimberti V, Sacchini V, Monti S, et al. Comparison of radioguided excision with wire location of occult breast lesion. Br J Surg. 1999;86:522–5.CrossRefPubMed
27.
go back to reference Paramo JC, Landeros M, Mcphee MD, Mesko TW, FACS. Intraoprative ultrasound-guided excision of nonpalpable breast lesions. Breast J. 1999;6:389–94.CrossRef Paramo JC, Landeros M, Mcphee MD, Mesko TW, FACS. Intraoprative ultrasound-guided excision of nonpalpable breast lesions. Breast J. 1999;6:389–94.CrossRef
28.
go back to reference Cochrane RA, Valasiadou P, Wilson AR, AI-Ghazal SK, Macmillan RD. Cosmesis and satisfaction after breast-conserving surgery correlates with the percentage of breast volume excised. Br J Surg. 2003;90:1505–9.CrossRefPubMed Cochrane RA, Valasiadou P, Wilson AR, AI-Ghazal SK, Macmillan RD. Cosmesis and satisfaction after breast-conserving surgery correlates with the percentage of breast volume excised. Br J Surg. 2003;90:1505–9.CrossRefPubMed
29.
go back to reference Vrieling C, Collette L, Fourquet A, Hoogenraad WJ, Horiot JH, Jager JJ, et al. The influence of patient tumor and treatment factors on the cosmetic results after breast-conserving therapy in the EORTC “boost vs. no boost” trail. EORTC radiotherapy and breast cancer cooperative groups. Radiother Oncol. 2000;55:219–32.CrossRefPubMed Vrieling C, Collette L, Fourquet A, Hoogenraad WJ, Horiot JH, Jager JJ, et al. The influence of patient tumor and treatment factors on the cosmetic results after breast-conserving therapy in the EORTC “boost vs. no boost” trail. EORTC radiotherapy and breast cancer cooperative groups. Radiother Oncol. 2000;55:219–32.CrossRefPubMed
Metadata
Title
Intraoperative indocyanine green fluorescence guidance for excision of nonpalpable breast cancer
Authors
Jintao Liu
Wenbin Guo
Meng Tong
Publication date
01-12-2016
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2016
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-016-1014-2

Other articles of this Issue 1/2016

World Journal of Surgical Oncology 1/2016 Go to the issue