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01-11-2016 | Maternal-Fetal Medicine

Intramuscular versus intravenous prophylactic oxytocin for postpartum hemorrhage after vaginal delivery: a randomized controlled study

Authors: Hediye Dagdeviren, Huseyin Cengiz, Ulkar Heydarova, Sema Suzen Caypinar, Ammar Kanawati, Ender Guven, Murat Ekin

Published in: Archives of Gynecology and Obstetrics | Issue 5/2016

Abstract

Purpose

Prevention of postpartum haemorrhage (PPH) is essential in the pursuit of improved health care for women. Oxytocin, the most commonly used uterotonic agent to prevent PPH, has no established the route of administration. In this study we aimed to compare whether the mode of oxytocin administration, i.e., intravenous and intramuscular administration, has an effect on the potential benefits and side effects.

Materials and methods

A total of 256 women were randomised into two groups: intramuscular group (128) or intravenous group (128).

Results

Estimated blood loss during the third stage of labour was similar between the two groups (p = 0.572). Further there were no statistically significant difference was noted between the two groups in terms of the mean duration of labor, duration of the third stage of labor, manual removal of the placenta, need for instrumental delivery, need for blood transfusion, PPH ≥500 mL, PPH ≥1000 mL, or length of hospital stay.

Conclusion

Using oxytocin by intravenous and intramuscular route has a similar efficacy and adverse effects.

Priya GP, Veena P, Chaturvedula L, Subitha L (2015) A randomized controlled trial of sublingual misoprostol and intramuscular oxytocin for prevention of postpartum hemorrhage. Arch Gynecol Obstet 292:1231–1237. doi:10.1007/s00404-015-3763-5 CrossRefPubMed

World Health Organization (2009) WHO guidelines for the management of postpartum haemorrhage and retained placenta

Kaul V, Bagga R, Jain V, Gopalan S (2006) The impact of primary postpartum hemorrhage in ‘Near-Miss’ morbidity and mortality in a tertiary care hospital in North India. Indian J Med Sci 60:233–240CrossRefPubMed

Lewis G (2007) The Confidential Enquiry into Maternal and Child Health (CEMACH) saving mother’s lives: reviewing maternal deaths to make motherhood safer, 2003–2005. The seventh report on Confidential Enquiry into Maternal Deaths in the United Kingdom. CEMACH, London

Wedisinghe L, Macleod M, Murphy DJ (2008) Use of oxytocin to prevent haemorrhage at caesarean section—a survey of practice in the United Kingdom. Eur J Obstet Gynecol Reprod Biol 137:27–30CrossRefPubMed

Bouwmeester FW, Bolte AC, van Geijn HP (2005) Pharmacological and surgical therapy for primary postpartum hemorrhage. Curr Pharm Des 11:759–773CrossRefPubMed

Davies GA, Tessier JL, Woodman MC, Lipson A, Hahn PM (2005) Maternal hemodynamics after oxytocin bolus compared with infusion in the third stage of labor: a randomized controlled trial. Obstet Gynecol 105:294–299CrossRefPubMed

Miller S, Lester F, Hensleigh P (2004) Prevention and treatment of postpartum hemorrhage: new advances for low-resource settings. J Midwifery Womens Health 49:283–292CrossRefPubMed

Rouse DJ, Owen J, Hauth JC (2000) Criteria for failed labor induction: prospective evaluation of a standardized protocol. Obstet Gynecol 96:671–677PubMed

10.

Chong YS, Su LL, Arulkumaran S (2004) Current strategies for the preventionof postpartum hemorrhage in the third stage of labor. Curr Opin Obstet Gynecol 16:143–150CrossRefPubMed

11.

Ying Gai Ming, Wu Lian-fang Su, Qi-feng Karin Tatsumoto (2004) Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: a multi-center, randomized trial. Eur J Obstet Gynecol Reprod Biol 112:154–157CrossRef

12.

Carroli G, Cuesta C, Abalos E, Gulmezoglu AM (2008) Epidemiology of postpartum haemorrhage: a systematic review. Best Pract Res Clin Obstet Gynaecol 22:999–1012CrossRefPubMed

13.

Cotter AM, Ness A, Tolosa JE (2001) Prophylactic oxytocin for the third stage of labour. Cochrane Database Syst Rev (4)

14.

Westhoff G, Cotter AM, Tolosa JE (2013) Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage. Cochrane Database Syst Rev 10:CD001808. doi:10.1002/14651858.CD001808.pub2 PubMed

15.

Davies GA, Tessier JL, Woodman MC, Lipson A, Hahn PM (2011) Maternal hemodynamics after oxytocin bolus compared with infusion in the third stage of labor: a randomized controlled trial. Obstet Gynecol 105:294–299CrossRef

16.

Soltani H, Hutchon DR, Poulose TA (2006) Timing of prophylactic uterotonics for the third stage of labour after vaginal birth. Cochrane Database Syst Rev (4)

17.

Jackson KW Jr, Allbert JR, Schemmer GK, Elliot M, Humphrey A, Taylor J (2001) A randomized controlled trial comparing oxytocin administration before and after placental delivery in the prevention of postpartum hemorrhage. Am J Obstet Gynecol 185:873–877CrossRefPubMed

18.

Breathnach F, Geary M (2006) Standard medical therapy. In: Blynch C, Keith LG, Lalonde AB, Karoshi M (eds) A textbook of postpartum haemorrhage. Sapiens Publishing, Duncow, pp 256–262

19.

Charbit B, Funck-Brentano C, Samain E, Jannier-Guillou V, Albaladejo P, Marty J (2007) QT interval prolongation after oxytocin bolus during surgical induced abortion. Clin Pharmacol Ther 76:359–364CrossRef

20.

Svanström MC, Biber B, Hanes M, Johansson G, Näslund U, Bålfors EM (2008) Signs of myocardial ischaemia after injection of oxytocin: a randomized double-blind comparison of oxytocin and methylergometrine during caesarean section. Br J Anaesth 100:683–689CrossRefPubMed

Title: Intramuscular versus intravenous prophylactic oxytocin for postpartum hemorrhage after vaginal delivery: a randomized controlled study
Authors: Hediye Dagdeviren
Huseyin Cengiz
Ulkar Heydarova
Sema Suzen Caypinar
Ammar Kanawati
Ender Guven
Murat Ekin
Publication date: 01-11-2016
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 5/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-016-4060-7

At a glance: The STEP trials

Springer Medicine

Intramuscular versus intravenous prophylactic oxytocin for postpartum hemorrhage after vaginal delivery: a randomized controlled study

Abstract

Purpose

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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