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Archives of Gynecology and Obstetrics

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01-11-2016 | Gynecologic Endocrinology and Reproductive Medicine

The association of DENND1A gene polymorphisms and polycystic ovary syndrome risk: a systematic review and meta-analysis

Authors: Jing Gao, Jing-Dong Xue, Zhi-Chao Li, Li Zhou, Chen Chen

Published in: Archives of Gynecology and Obstetrics | Issue 5/2016

Abstract

Purpose

Polycystic ovary syndrome is heterogeneity disease, and the association with DEEND1A gene has been discussed incompatibly for a long time. We conducted a meta-analysis to evaluate the rs10818854, rs2479106, and rs10986105 polymorphism in DENND1A gene with PCOS susceptibility.

Methods

Meta-analysis was performed for common allele versus rare allele using random effect model on published papers from January 1, 1980 to October 1, 2015. Subgroup analysis, sensitivity analysis and publication bias were also carried out ultimately. The combined odds ratio (OR) with 95 % confidence interval (95 % CI) was calculated to estimate the strength of the association.

Results

The results showed that rs10818854 (OR = 1.36, 95 % CI 1.12–1.61) and rs10986105 (OR = 1.39, 95 % CI 1.20–1.58) polymorphism increased the risk of PCOS probably. A significant association was also found between rs2479106 mutation and Asian PCOS patients but not Europeans (OR = 1.32, 95 % CI 1.25–1.39; OR = 1.01, 95 % CI 0.97–1.05, respectively).

Conclusions

In conclusion, the DENND1A gene variant is likely to have influence on PCOS risk. Further studies are warranted to assess these associations in greater detail, especially in different populations and different subtype of PCOS patients.

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Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, Carmina H, Chang RJ, Yildiz BO, Laven JS, Boivin J, Petraglia F, Wijeyeratne CN, Norman RJ, Dunaif A, Franks S, Wild RA, Dumesic D, Barnhart K, Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group (2012) Consensus on women’s health aspects of polycystic ovary syndrome (PCOS). Hum Reprod 27(1):14–24. doi:10.1093/humrep/der396 (Oxford, England) CrossRef

Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, Welt CK, Endocrine S (2013) Diagnosis and treatment of polycystic ovary syndrome: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 98(12):4565–4592. doi:10.1210/jc.2013-2350 CrossRefPubMed

Strauss JF 3rd, McAllister JM, Urbanek M (2012) Persistence pays off for PCOS gene prospectors. J Clin Endocrinol Metab 97(7):2286–2288. doi:10.1210/jc.2012-2109 CrossRefPubMedPubMedCentral

Chen ZJ, Zhao H, He L, Shi Y, Qin Y, Shi Y, Li Z, You L, Zhao J, Liu J, Liang X, Zhao X, Zhao J, Sun Y, Zhang B, Jiang H, Zhao D, Bian Y, Gao X, Geng L, Li Y, Zhu D, Sun X, Xu JE, Hao C, Ren CE, Zhang Y, Chen S, Zhang W, Yang A, Yan J, Li Y, Ma J, Zhao Y (2011) Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet 43(1):55–59. doi:10.1038/ng.732 CrossRefPubMed

Day FR, Hinds DA, Tung JY, Stolk L, Styrkarsdottir U, Saxena R, Bjonnes A, Broer L, Dunger DB, Halldorsson BV, Lawlor DA, Laval G, Mathieson I, McCardle WL, Louwers Y, Meun C, Ring S, Scott RA, Sulem P, Uitterlinden AG, Wareham NJ, Thorsteinsdottir U, Welt C, Stefansson K, Laven JS, Ong KK, Perry JR (2015) Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome. Nat Commun 6:8464. doi:10.1038/ncomms9464 CrossRefPubMedPubMedCentral

Marat AL, McPherson PS (2010) The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery. J Biol Chem 285(14):10627–10637. doi:10.1074/jbc.M109.050930 CrossRefPubMedPubMedCentral

Allaire PD, Marat AL, Dall’Armi C, Di Paolo G, McPherson PS, Ritter B (2010) The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes. Mol Cell 37(3):370–382. doi:10.1016/j.molcel.2009.12.037 CrossRefPubMedPubMedCentral

Eapen BR (2006) EndNote 7.0. Indian J Dermatol Venereol Leprol 72(2):165–166CrossRefPubMed

Higgins JPT, Green S (2014) Cochrane handbook for systematic reviews of interventions version 5.1.0 (updated March 2011). The cochrane collaboration 2011. Available from http://www.cochrane-handbook.org. Accessed 26 Mar 2014

10.

Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P (2004) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm. Accessed 29 Apr 2004

11.

Lundh A, Gotzsche PC (2008) Recommendations by Cochrane Review Groups for assessment of the risk of bias in studies. BMC Med Res Methodol 8:22. doi:10.1186/1471-2288-8-22 CrossRefPubMedPubMedCentral

12.

Bauer T, Bouman HJ, van Werkum JW, Ford NF, ten Berg JM, Taubert D (2011) Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis. BMJ 343:d4588. doi:10.1136/bmj.d4588 CrossRefPubMedPubMedCentral

13.

Thakkinstian A, McElduff P, D’Este C, Duffy D, Attia J (2005) A method for meta-analysis of molecular association studies. Stat Med 24(9):1291–1306. doi:10.1002/sim.2010 CrossRefPubMed

14.

Midgette AS, Wong JB, Beshansky JR, Porath A, Fleming C, Pauker SG (1994) Cost-effectiveness of streptokinase for acute myocardial infarction: a combined meta-analysis and decision analysis of the effects of infarct location and of likelihood of infarction. Med Decis Mak 14(2):108–117CrossRef

15.

Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629–634. doi:10.1136/bmj.315.7109.629 CrossRefPubMedPubMedCentral

16.

Lerchbaum E, Trummer O, Giuliani A, Gruber HJ, Pieber TR, Obermayer-Pietsch B (2011) Susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21, and 9q33.3 in a cohort of Caucasian women. Horm Metab Res 43(11):743–747. doi:10.1055/s-0031-1286279 CrossRefPubMed

17.

Goodarzi MO, Jones MR, Li X, Chua AK, Garcia OA, Chen YD, Krauss RM, Rotter JI, Ankener W, Legro RS, Azziz R, Strauss JF 3rd, Dunaif A, Urbanek M (2012) Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts. J Med Genet 49(2):90–95. doi:10.1136/jmedgenet-2011-100427 CrossRefPubMed

18.

Eriksen MB, Brusgaard K, Andersen M, Tan Q, Altinok ML, Gaster M, Glintborg D (2012) Association of polycystic ovary syndrome susceptibility single nucleotide polymorphism rs2479106 and PCOS in Caucasian patients with PCOS or hirsutism as referral diagnosis. Eur J Obstet Gynecol Reprod Biol 163(1):39–42. doi:10.1016/j.ejogrb.2012.03.020 CrossRefPubMed

19.

Welt CK, Styrkarsdottir U, Ehrmann DA, Thorleifsson G, Arason G, Gudmundsson JA, Ober C, Rosenfield RL, Saxena R, Thorsteinsdottir U, Crowley WF, Stefansson K (2012) Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry. J Clin Endocrinol Metab 97(7):E1342–E1347. doi:10.1210/jc.2011-3478 CrossRefPubMedPubMedCentral

20.

Shi Y, Zhao H, Shi Y, Cao Y, Yang D, Li Z, Zhang B, Liang X, Li T, Chen J, Shen J, Zhao J, You L, Gao X, Zhu D, Zhao X, Yan Y, Qin Y, Li W, Yan J, Wang Q, Zhao J, Geng L, Ma J, Zhao Y, He G, Zhang A, Zou S, Yang A, Liu J, Li W, Li B, Wan C, Qin Y, Shi J, Yang J, Jiang H, Xu JE, Qi X, Sun Y, Zhang Y, Hao C, Ju X, Zhao D, Ren CE, Li X, Zhang W, Zhang Y, Zhang J, Wu D, Zhang C, He L, Chen ZJ (2012) Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet 44(9):1020–1025. doi:10.1038/ng.2384 CrossRefPubMed

21.

Louwers YV, Stolk L, Uitterlinden AG, Laven JS (2013) Cross-ethnic meta-analysis of genetic variants for polycystic ovary syndrome. J Clin Endocrinol Metab 98(12):E2006–E2012. doi:10.1210/jc.2013-2495 CrossRefPubMed

22.

Gammoh E, Arekat MR, Saldhana FL, Madan S, Ebrahim BH, Almawi WY (2015) DENND1A gene variants in Bahraini Arab women with polycystic ovary syndrome. Gene 560(1):30–33. doi:10.1016/j.gene.2015.01.034 CrossRefPubMed

23.

Ha L, Shi Y, Zhao J, Li T, Chen ZJ (2015) Association study between polycystic ovarian syndrome and the susceptibility genes polymorphisms in Hui Chinese Women. PLoS One 10(5):e0126505. doi:10.1371/journal.pone.0126505 CrossRefPubMedPubMedCentral

24.

Rotterdam EA-SPcwg (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19(1):41–47 (Oxford, England) CrossRef

25.

DA Zawadzki JK (1992) Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif A, Givens JR, Haseltine FP, Merriam GR (eds) polycystic ovary syndrome. Blackwell Scientific, Boston, pp 377–384

26.

Vink JM, Sadrzadeh S, Lambalk CB, Boomsma DI (2006) Heritability of polycystic ovary syndrome in a Dutch twin-family study. J Clin Endocrinol Metab 91(6):2100–2104. doi:10.1210/jc.2005-1494 CrossRefPubMed

27.

Zhao H, Xu X, Xing X, Wang J, He L, Shi Y, Shi Y, Zhao Y, Chen ZJ (2012) Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Hum Reprod 27(1):294–298. doi:10.1093/humrep/der379 (Oxford, England) CrossRefPubMed

28.

Wang Z, Li T, Zhang W, You L, Zhao Y, Xia M, Zhao H, Chen ZJ (2012) Variants in DENND1A and LHCGR are associated with endometrioid adenocarcinoma. Gynecol Oncol 127(2):403–405. doi:10.1016/j.ygyno.2012.08.007 CrossRefPubMed

29.

Eriksen MB, Nielsen MF, Brusgaard K, Tan Q, Andersen MS, Glintborg D, Gaster M (2013) Genetic alterations within the DENND1A gene in patients with polycystic ovary syndrome (PCOS). PLoS One 8(9):e77186. doi:10.1371/journal.pone.0077186 CrossRefPubMedPubMedCentral

30.

McAllister JM, Modi B, Miller BA, Biegler J, Bruggeman R, Legro RS, Strauss JF 3rd (2014) Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype. Proc Natl Acad Sci USA 111(15):E1519–E1527. doi:10.1073/pnas.1400574111 CrossRefPubMedPubMedCentral

31.

Mou C (2014) Effect of testosterone on the in vitro mouse follicle development and construction of lentiviral vector carrying mouse Denndla gene. Dissertation, Shandong University

32.

Cui L, Zhao H, Zhang B, Qu Z, Liu J, Liang X, Zhao X, Zhao J, Sun Y, Wang P, Li T, Shi Y, Chen ZJ (2013) Genotype-phenotype correlations of PCOS susceptibility SNPs identified by GWAS in a large cohort of Han Chinese women. Hum Reprod 28(2):538–544. doi:10.1093/humrep/des424 (Oxford, England) CrossRefPubMed

33.

Sun M, Sheng Y, Ma Z, Chen Z, Tang R (2014) Correlation analysis between polycystic ovary syndrome susceptibility genes and metabolic phenotypes. Zhonghua fu chan ke za zhi 49(6):441–445PubMed

Title: The association of DENND1A gene polymorphisms and polycystic ovary syndrome risk: a systematic review and meta-analysis
Authors: Jing Gao
Jing-Dong Xue
Zhi-Chao Li
Li Zhou
Chen Chen
Publication date: 01-11-2016
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 5/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-016-4159-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The association of DENND1A gene polymorphisms and polycystic ovary syndrome risk: a systematic review and meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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