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BMC Cancer
Published in: BMC Cancer 1/2006

Open Access 01-12-2006 | Technical advance

Intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports

Authors: Georg Seifert, Hanno Riess, Karl Seeger, Guenter Henze, Anja Borgmann

Published in: BMC Cancer | Issue 1/2006

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Abstract

Background

Therapeutic use and effective function of recombinant urokinase (r-UK) for occluded ports need the presence of plasminogen.

Methods

As a therapeutic proof of principle, we demonstrate that the use of r-UK and autologous plasma effectively reestablishes the function of occluded central venous ports (CVP) resistant to routine management of catheter occlusion. Five patients with occluded ports resistant to the routine management were treated.

Results

All patients were successfully treated with thrombolytic therapy using intraluminal instillation of r-UK and autologous plasma.

Conclusion

Instillation of r-UK and autologous plasma is a safe and effective method for management of CVP occlusion.
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Literature
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Glynn MF, Langer B, Jeejeebhoy KN: Therapy for thrombotic occlusion of long-term intravenous alimentation catheters. JPEN J Parenter Enteral Nutr. 1980, 4: 387-390.CrossRefPubMed
2.
Hurtubise MR, Bottino JC, Lawson M, McCredie KB: Restoring patency of occluded central venous catheters. Arch Surg. 1980, 115: 212-213.CrossRefPubMed
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Collen D, Lijnen HR: Thrombolytic agents. Thromb Haemost. 2005, 93: 627-630.PubMed
4.
Wachs T: Urokinase administration in pediatric patients with occluded central venous catheters. J Intraven Nurs. 1990, 13: 100-102.PubMed
Metadata
Title
Intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports
Authors
Georg Seifert
Hanno Riess
Karl Seeger
Guenter Henze
Anja Borgmann
Publication date
01-12-2006
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2006
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-6-103

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