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Journal of Gastrointestinal Surgery

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01-03-2012 | Original Article

Intrahepatic Cholangiocarcinoma: Clinicopathological Differences Between Peripheral Type and Hilar Type

Authors: Yoshiaki Murakami, Kenichiro Uemura, Takeshi Sudo, Yasushi Hashimoto, Akira Nakashima, Taijiro Sueda

Published in: Journal of Gastrointestinal Surgery | Issue 3/2012

Abstract

Background

Intrahepatic cholangiocarcinoma (ICC) is categorized as peripheral ICC (PICC) or hilar ICC (HICC). The aims of this study are to clarify clinicopathological differences between PICC and HICC and to determine useful prognostic factors for patients with ICC following aggressive surgical resection.

Methods

Medical records of 44 patients with ICC who underwent surgical resection were retrospectively reviewed. Clinicopathological factors were compared between patients with PICC and HICC. Univariate and multivariate models were used to analyze the effect of clinicopathological factors on disease-specific survival.

Results

Disease-specific survival rates for the 44 patients were 76% at 1 year, 60% at 3 years, and 47% at 5 years. Clinicopathological factors did not differ between patients with PICC and HICC except preoperative jaundice (P < 0.001), preoperative biliary drainage (P = 0.001), postoperative complication (P = 0.046), and macroscopic type (P < 0.001). Multivariate analysis revealed that only lymph node status was an independent prognostic factor of disease-specific survival. The 5-year disease-specific survival rates of patients with or without nodal involvement were 23% and 66%, respectively (P = 0.004).

Conclusions

Clinicopathological characteristics are almost similar between patients with PICC and HICC. Nodal involvement is a potent prognostic factor for patients with ICC.

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Title: Intrahepatic Cholangiocarcinoma: Clinicopathological Differences Between Peripheral Type and Hilar Type
Authors: Yoshiaki Murakami
Kenichiro Uemura
Takeshi Sudo
Yasushi Hashimoto
Akira Nakashima
Taijiro Sueda
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 3/2012
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-011-1730-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intrahepatic Cholangiocarcinoma: Clinicopathological Differences Between Peripheral Type and Hilar Type

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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