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Journal of Hepato-Biliary-Pancreatic Sciences

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01-05-2011 | Original Article

Impact of nodal involvement on surgical outcomes of intrahepatic cholangiocarcinoma: a multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery

Authors: Kazuhisa Uchiyama, Masakazu Yamamoto, Hiroki Yamaue, Shun-ichi Ariizumi, Taku Aoki, Norihiro Kokudo, Tomoki Ebata, Masato Nagino, Masayuki Ohtsuka, Masaru Miyazaki, Eiichi Tanaka, Satoshi Kondo, Takahiro Uenishi, Shoji Kubo, Hiroshi Yoshida, Michiaki Unno, Satoru Imura, Mitsuo Shimada, Masaki Ueno, Tadahiro Takada

Published in: Journal of Hepato-Biliary-Pancreatic Sciences | Issue 3/2011

Abstract

Background/purpose

The aim of this study was to clarify the prognostic factors of intrahepatic cholangiocarcinoma (ICC) following hepatectomy and to examine the impact of lymph node metastasis on survival. This study was therefore carried out as a Project Study of the Japanese Society of Hepato-Biliary-Pancreatic Surgery.

Methods

Three hundred and forty-one patients who underwent hepatectomy for ICC between 1995 and 2004 at the 9 institutions of the Medical University Hospitals were analyzed retrospectively. Multivariate regression analyses and a Kaplan–Meyer analysis were performed to identify prognostic factors.

Results

Pathological lymph node metastasis was one of the significant factors affecting overall survival (hazard ratio 2.10, p < 0.001) based on the multivariate analysis. Among the patients who underwent extended lymphadenectomy beyond the hepatoduodenal ligament, the median survival of 121 patients with nodal involvement was 12.2 months. Only seven patients with nodal involvement have survived for more than 4 years.

Conclusions

In the present study, preoperative carbohydrate antigen (CA) 19-9, intrahepatic metastasis, and nodal involvement were the significant independent predictors of poor prognosis by multivariate analysis. Further prospective studies may thus be needed to confirm these findings, because this study has a limitation in that it was a retrospective study with multicenter data collection.

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Title: Impact of nodal involvement on surgical outcomes of intrahepatic cholangiocarcinoma: a multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery
Authors: Kazuhisa Uchiyama
Masakazu Yamamoto
Hiroki Yamaue
Shun-ichi Ariizumi
Taku Aoki
Norihiro Kokudo
Tomoki Ebata
Masato Nagino
Masayuki Ohtsuka
Masaru Miyazaki
Eiichi Tanaka
Satoshi Kondo
Takahiro Uenishi
Shoji Kubo
Hiroshi Yoshida
Michiaki Unno
Satoru Imura
Mitsuo Shimada
Masaki Ueno
Tadahiro Takada
Publication date: 01-05-2011
Publisher: Springer Japan
Published in: Journal of Hepato-Biliary-Pancreatic Sciences / Issue 3/2011
Print ISSN: 1868-6974
Electronic ISSN: 1868-6982
DOI: https://doi.org/10.1007/s00534-010-0349-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Impact of nodal involvement on surgical outcomes of intrahepatic cholangiocarcinoma: a multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery

Abstract

Background/purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background/purpose

Methods

Results

Conclusions

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