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Published in: Child's Nervous System 4/2020

01-04-2020 | Intracranial Hypertension | Review Article

Intracranial pressure, brain morphology and cognitive outcome in children with sagittal craniosynostosis

Authors: Amalie E. Thiele-Nygaard, Jon Foss-Skiftesvik, Marianne Juhler

Published in: Child's Nervous System | Issue 4/2020

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Abstract

Background

Patients with sagittal craniosynostosis are at increased risk of developing raised intracranial pressure (ICP) and neurocognitive deficiencies such as reduced attention, planning, speech, behavioural and learning disabilities.

Aim

To determine if the existing literature supports a correlation between elevated ICP and negative cognitive outcome in patients with sagittal craniosynostosis. Secondly, to investigate if the risk of developing neurocognitive deficiencies can be explained by changes in brain morphology in this patient category.

Methods

Systematic literature review in PubMed.

Results

A total of 190 publications were reviewed to determine a possible correlation between raised ICP and cognitive outcome, of which four were included in the study. No significant association was found. Forty-four publications on brain morphology in sagittal craniosynostosis were identified, of which 11 were included in the review. Clear evidence of morphologic changes in multiple areas of the brains of sagittal craniosynostosis patients was found in the literature.

Conclusion

The existing literature does not support an association between increased ICP and negative global cognitive outcome measures in patients with sagittal craniosynostosis. Brain morphology is altered in areas related to neurocognition and language in the same patient group. These changes might play a role in the development of neurocognitive deficiencies, though no definitive link is yet established, and further investigation is warranted.
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Literature
1.
go back to reference Knight SJ, Anderson VA, Spencer-Smith MM, Da Costa AC (2014) Neurodevelopmental outcomes in infants and children with single-suture craniosynostosis: a systematic review. Dev Neuropsychol 39(3):159–186CrossRef Knight SJ, Anderson VA, Spencer-Smith MM, Da Costa AC (2014) Neurodevelopmental outcomes in infants and children with single-suture craniosynostosis: a systematic review. Dev Neuropsychol 39(3):159–186CrossRef
2.
go back to reference Massimi L, Caldarelli M, Tamburrini G, Paternoster G, Di Rocco C (2012) Isolated sagittal craniosynostosis: definition, classification, and surgical indications. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 28(9):1311–1317CrossRef Massimi L, Caldarelli M, Tamburrini G, Paternoster G, Di Rocco C (2012) Isolated sagittal craniosynostosis: definition, classification, and surgical indications. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 28(9):1311–1317CrossRef
3.
go back to reference Kapp-Simon KA, Speltz ML, Cunningham ML, Patel PK, Tomita T (2007) Neurodevelopment of children with single suture craniosynostosis: a review. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 23(3):269–281CrossRef Kapp-Simon KA, Speltz ML, Cunningham ML, Patel PK, Tomita T (2007) Neurodevelopment of children with single suture craniosynostosis: a review. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 23(3):269–281CrossRef
4.
go back to reference Bristol RE, Lekovic GP, Rekate HL (2004) The effects of craniosynostosis on the brain with respect to intracranial pressure. Semin Pediatr Neurol 11(4):262–267CrossRef Bristol RE, Lekovic GP, Rekate HL (2004) The effects of craniosynostosis on the brain with respect to intracranial pressure. Semin Pediatr Neurol 11(4):262–267CrossRef
5.
go back to reference Speltz ML, Kapp-Simon KA, Cunningham M, Marsh J, Dawson G (2004) Single-suture craniosynostosis: a review of neurobehavioral research and theory. J Pediatr Psychol 29(8):651–668CrossRef Speltz ML, Kapp-Simon KA, Cunningham M, Marsh J, Dawson G (2004) Single-suture craniosynostosis: a review of neurobehavioral research and theory. J Pediatr Psychol 29(8):651–668CrossRef
6.
go back to reference Arnaud E, Renier D, Marchac D (1995) Prognosis for mental function in scaphocephaly. J Neurosurg 83(3):476–479CrossRef Arnaud E, Renier D, Marchac D (1995) Prognosis for mental function in scaphocephaly. J Neurosurg 83(3):476–479CrossRef
7.
go back to reference Iyengar RJ, Klinge PM, Chen WS, Boxerman JL, Sullivan SR, Taylor HO (2016) Management of craniosynostosis at an advanced age: controversies, clinical findings, and surgical treatment. The Journal of craniofacial surgery. 27(5):e435–e441CrossRef Iyengar RJ, Klinge PM, Chen WS, Boxerman JL, Sullivan SR, Taylor HO (2016) Management of craniosynostosis at an advanced age: controversies, clinical findings, and surgical treatment. The Journal of craniofacial surgery. 27(5):e435–e441CrossRef
8.
go back to reference Engel M, Hoffmann J, Muhling J, Castrillon-Oberndorfer G, Seeberger R, Freudlsperger C (2012) Magnetic resonance imaging in isolated sagittal synostosis. The Journal of craniofacial surgery. 23(4):e366–e369CrossRef Engel M, Hoffmann J, Muhling J, Castrillon-Oberndorfer G, Seeberger R, Freudlsperger C (2012) Magnetic resonance imaging in isolated sagittal synostosis. The Journal of craniofacial surgery. 23(4):e366–e369CrossRef
9.
go back to reference Thomas GP, Johnson D, Byren JC, Judge AD, Jayamohan J, Magdum SA, Richards PG, Wall SA (2015) The incidence of raised intracranial pressure in nonsyndromic sagittal craniosynostosis following primary surgery. J Neurosurg Pediatr 15(4):350–360CrossRef Thomas GP, Johnson D, Byren JC, Judge AD, Jayamohan J, Magdum SA, Richards PG, Wall SA (2015) The incidence of raised intracranial pressure in nonsyndromic sagittal craniosynostosis following primary surgery. J Neurosurg Pediatr 15(4):350–360CrossRef
10.
go back to reference Wall SA, Thomas GP, Johnson D, Byren JC, Jayamohan J, Magdum SA, McAuley D, Richards PG (2014) The preoperative incidence of raised intracranial pressure in nonsyndromic sagittal craniosynostosis is underestimated in the literature. J Neurosurg Pediatr 14(6):674–681CrossRef Wall SA, Thomas GP, Johnson D, Byren JC, Jayamohan J, Magdum SA, McAuley D, Richards PG (2014) The preoperative incidence of raised intracranial pressure in nonsyndromic sagittal craniosynostosis is underestimated in the literature. J Neurosurg Pediatr 14(6):674–681CrossRef
11.
go back to reference Renier D, Marchac D (1988) Craniofacial surgery for craniosynostosis: functional and morphological results. Ann Acad Med Singap 17(3):415–426PubMed Renier D, Marchac D (1988) Craniofacial surgery for craniosynostosis: functional and morphological results. Ann Acad Med Singap 17(3):415–426PubMed
12.
go back to reference Paniagua B, Kim S, Moustapha M, Styner M, Cody-Hazlett H, Gimple-Smith R et al (2017) Brain structure in sagittal craniosynostosis. Proceedings of SPIE--the International Society for Optical Engineering 10137 Paniagua B, Kim S, Moustapha M, Styner M, Cody-Hazlett H, Gimple-Smith R et al (2017) Brain structure in sagittal craniosynostosis. Proceedings of SPIE--the International Society for Optical Engineering 10137
13.
go back to reference Aldridge K, Collett BR, Wallace ER, Birgfeld C, Austin JR, Yeh R et al (2017) Structural brain differences in school-age children with and without single-suture craniosynostosis. J Neurosurg Pediatr 19(4):479–489CrossRef Aldridge K, Collett BR, Wallace ER, Birgfeld C, Austin JR, Yeh R et al (2017) Structural brain differences in school-age children with and without single-suture craniosynostosis. J Neurosurg Pediatr 19(4):479–489CrossRef
14.
go back to reference Yang CE, Park EK, Lee MC, Shim KW, Kim YO (2017) The unnecessity of positron emission tomography computed tomography in the etiologic evaluation of neurodevelopmental delay in craniosynostosis patients. Archives of craniofacial surgery 18(1):21–24CrossRef Yang CE, Park EK, Lee MC, Shim KW, Kim YO (2017) The unnecessity of positron emission tomography computed tomography in the etiologic evaluation of neurodevelopmental delay in craniosynostosis patients. Archives of craniofacial surgery 18(1):21–24CrossRef
15.
go back to reference Hukki A, Koljonen V, Karppinen A, Valanne L, Leikola J (2012) Brain anomalies in 121 children with non-syndromic single suture craniosynostosis by MR imaging. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 16(6):671–675CrossRef Hukki A, Koljonen V, Karppinen A, Valanne L, Leikola J (2012) Brain anomalies in 121 children with non-syndromic single suture craniosynostosis by MR imaging. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 16(6):671–675CrossRef
16.
go back to reference Strahle J, Muraszko KM, Buchman SR, Kapurch J, Garton HJ, Maher CO (2011) Chiari malformation associated with craniosynostosis. Neurosurg Focus 31(3):E2CrossRef Strahle J, Muraszko KM, Buchman SR, Kapurch J, Garton HJ, Maher CO (2011) Chiari malformation associated with craniosynostosis. Neurosurg Focus 31(3):E2CrossRef
17.
go back to reference Brooks ED, Yang J, Beckett JS, Lacadie C, Scheinost D, Persing S, Zellner EG, Oosting D, Keifer C, Friedman HE, Wyk BV, Jou RJ, Sun H, Gary C, Duncan CC, Constable RT, Pelphrey KA, Persing JA (2016) Normalization of brain morphology after surgery in sagittal craniosynostosis. J Neurosurg Pediatr 17(4):460–468CrossRef Brooks ED, Yang J, Beckett JS, Lacadie C, Scheinost D, Persing S, Zellner EG, Oosting D, Keifer C, Friedman HE, Wyk BV, Jou RJ, Sun H, Gary C, Duncan CC, Constable RT, Pelphrey KA, Persing JA (2016) Normalization of brain morphology after surgery in sagittal craniosynostosis. J Neurosurg Pediatr 17(4):460–468CrossRef
18.
go back to reference Beckett JS, Brooks ED, Lacadie C, Vander Wyk B, Jou RJ, Steinbacher DM, Constable RT, Pelphrey KA, Persing JA (2014) Altered brain connectivity in sagittal craniosynostosis. J Neurosurg Pediatr 13(6):690–698CrossRef Beckett JS, Brooks ED, Lacadie C, Vander Wyk B, Jou RJ, Steinbacher DM, Constable RT, Pelphrey KA, Persing JA (2014) Altered brain connectivity in sagittal craniosynostosis. J Neurosurg Pediatr 13(6):690–698CrossRef
19.
go back to reference Aldridge K, Kane AA, Marsh JL, Yan P, Govier D, Richtsmeier JT (2005) Relationship of brain and skull in pre- and postoperative sagittal synostosis. J Anat 206(4):373–385CrossRef Aldridge K, Kane AA, Marsh JL, Yan P, Govier D, Richtsmeier JT (2005) Relationship of brain and skull in pre- and postoperative sagittal synostosis. J Anat 206(4):373–385CrossRef
20.
go back to reference Aldridge K, Marsh JL, Govier D, Richtsmeier JT (2002) Central nervous system phenotypes in craniosynostosis. J Anat 201(1):31–39CrossRef Aldridge K, Marsh JL, Govier D, Richtsmeier JT (2002) Central nervous system phenotypes in craniosynostosis. J Anat 201(1):31–39CrossRef
21.
go back to reference Rangel-Castilla L, Gopinath S, Robertson CS (2008) Management of intracranial hypertension. Neurol Clin 26(2):521–541. xCrossRef Rangel-Castilla L, Gopinath S, Robertson CS (2008) Management of intracranial hypertension. Neurol Clin 26(2):521–541. xCrossRef
22.
go back to reference Dunn LT (2002) Raised intracranial pressure. J Neurol Neurosurg Psychiatry 73(Suppl 1):i23–i27CrossRef Dunn LT (2002) Raised intracranial pressure. J Neurol Neurosurg Psychiatry 73(Suppl 1):i23–i27CrossRef
23.
go back to reference Chieffo D, Tamburrini G, Massimi L, Di Giovanni S, Giansanti C, Caldarelli M et al (2010) Long-term neuropsychological development in single-suture craniosynostosis treated early. J Neurosurg Pediatr 5(3):232–237CrossRef Chieffo D, Tamburrini G, Massimi L, Di Giovanni S, Giansanti C, Caldarelli M et al (2010) Long-term neuropsychological development in single-suture craniosynostosis treated early. J Neurosurg Pediatr 5(3):232–237CrossRef
24.
go back to reference Friederici AD (2015) White-matter pathways for speech and language processing. Handb Clin Neurol 129:177–186CrossRef Friederici AD (2015) White-matter pathways for speech and language processing. Handb Clin Neurol 129:177–186CrossRef
25.
go back to reference Marien P, Borgatti R (2018) Language and the cerebellum. Handb Clin Neurol 154:181–202CrossRef Marien P, Borgatti R (2018) Language and the cerebellum. Handb Clin Neurol 154:181–202CrossRef
26.
go back to reference Brooks ED, Beckett JS, Yang J, Timberlake AT, Sun AH, Chuang C, Persing JA (2018) The etiology of neuronal development in craniosynostosis: a working hypothesis. The Journal of craniofacial surgery 29(1):49–55CrossRef Brooks ED, Beckett JS, Yang J, Timberlake AT, Sun AH, Chuang C, Persing JA (2018) The etiology of neuronal development in craniosynostosis: a working hypothesis. The Journal of craniofacial surgery 29(1):49–55CrossRef
27.
go back to reference Chuang C, Rolison M, Yang JF, Brooks ED, Hashim PW, Travieso R et al (2018) Normalization of speech processing after whole-vault cranioplasty in sagittal synostosis. The Journal of craniofacial surgery. 29(5):1132–1136CrossRef Chuang C, Rolison M, Yang JF, Brooks ED, Hashim PW, Travieso R et al (2018) Normalization of speech processing after whole-vault cranioplasty in sagittal synostosis. The Journal of craniofacial surgery. 29(5):1132–1136CrossRef
Metadata
Title
Intracranial pressure, brain morphology and cognitive outcome in children with sagittal craniosynostosis
Authors
Amalie E. Thiele-Nygaard
Jon Foss-Skiftesvik
Marianne Juhler
Publication date
01-04-2020
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 4/2020
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-020-04502-z

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