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Neurological Sciences

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01-08-2019 | Intracranial Aneurysm | Original Article

Intracranial aneurysm rupture score may correlate to the risk of rebleeding before treatment of ruptured intracranial aneurysms

Authors: Qingyuan Liu, Pengjun Jiang, Jun Wu, Maogui Li, Bin Gao, Yanan Zhang, Bo Ning, Yong Cao, Shuo Wang

Published in: Neurological Sciences | Issue 8/2019

Abstract

Background and objective

Aneurysm rebleeding after rupture can result in a catastrophic outcome with high mortality and morbidity. In this study, we evaluated the correlation of IARS (intracranial aneurysm rupture score) and aneurysm rebleeding. The aim of this study was to explore the clinical utility of IARS for better clinical decision-making.

Method

The patients with ruptured intracranial aneurysms between January 2017 and September 2018 were reviewed. Propensity scoring match was performed to construct a cohort. The morphological and hemodynamic parameters were obtained. The difference between stable aneurysms and rebleeding aneurysms was compared. Subsequently, the correlation of IARS and aneurysm rebleeding was studied.

Results

The matching process constructed a cohort, including 5 rebleeding aneurysms and 15 stable aneurysms. By comparing the difference between stable aneurysms and rebleeding aneurysms, the statistical significance was found in diameter of neck (p = 0.036), aspect ratio (p = 0.004) and size ratio (p = 0.029), normalized wall shear stress average (p = 0.026), low shear area ratio (p = 0.028), oscillatory shear index (OSI) (p = 0.031), and deviated angle (p = 0.025). The IARS here had a strong correlation with the aneurysm rebleeding, and the interval from the first bleeding to the rebleeding tended to shorten with the increase of IARS (R = 0.715, p = 0.027). IARS had a good predicting value for the aneurysm rebleeding (area under the curve = 0.756, p < 0.001).

Conclusion

Based on this preliminary study, intracranial aneurysm rupture score may correlate to the rebleeding in ruptured aneurysms. For ruptured aneurysms with high IARS scores, surgery should be given priority, and medical treatment is not recommended.

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Title: Intracranial aneurysm rupture score may correlate to the risk of rebleeding before treatment of ruptured intracranial aneurysms
Authors: Qingyuan Liu
Pengjun Jiang
Jun Wu
Maogui Li
Bin Gao
Yanan Zhang
Bo Ning
Yong Cao
Shuo Wang
Publication date: 01-08-2019
Publisher: Springer International Publishing
Keywords: Intracranial Aneurysm
Aneurysm
Aneurysm
Published in: Neurological Sciences / Issue 8/2019
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-03916-1

At a glance: The STEP trials

Springer Medicine

Intracranial aneurysm rupture score may correlate to the risk of rebleeding before treatment of ruptured intracranial aneurysms

Abstract

Background and objective

Method

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background and objective

Method

Results

Conclusion

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