Skip to main content
Top
Published in: Ophthalmology and Therapy 1/2019

Open Access 01-10-2019 | Review

Intracorneal Ring Segment Implantation in the Management of Keratoconus: An Evidence-Based Approach

Authors: Dimitris Sakellaris, Miltos Balidis, Olga Gorou, Nora Szentmary, Antonios Alexoudis, Matthias C. Grieshaber, Despoina Sagri, Hendrik Scholl, Zisis Gatzioufas

Published in: Ophthalmology and Therapy | Special Issue 1/2019

Login to get access

Abstract

Intracorneal ring segment (ICRS) implantation represents a modern, minimally invasive, surgical option for visual improvement in patients with keratoconus. ICRS modify the corneal geometry in a manner that enhances its refractive properties and thereby, they improve visual acuity. It is well-documented that implantation of ICRS decreases the keratometric readings, spherical equivalent and cylinder, reduces high-order aberrations and improves uncorrected distance visual acuity (UDVA) and best-corrected distance visual acuity (BCDVA) in patients with keratoconus. Success rate after ICRS implantation is high, depending on appropriate patient selection and adherence to suitable implantation nomograms, and most important, the overall complication rate is very low. This review is summarizing current indications/contra-indications for ICRS implantation, implantation techniques, clinical outcomes and potential complications, shedding light on myths and realities related to this innovative surgical option.
Literature
2.
3.
go back to reference Vega-Estrada A, Alió JL, Plaza Puche AB, et al. Outcomes of a new microwave procedure followed by accelerated cross-linking for the treatment of keratoconus: a pilot study. J Refract Surg. 2012;28:787–93.PubMedCrossRef Vega-Estrada A, Alió JL, Plaza Puche AB, et al. Outcomes of a new microwave procedure followed by accelerated cross-linking for the treatment of keratoconus: a pilot study. J Refract Surg. 2012;28:787–93.PubMedCrossRef
4.
go back to reference Colin J, Cochener B, Savary G, et al. Correcting keratoconus with intracorneal rings. J Cataract Refract Surg. 2000;26:1117–22.PubMedCrossRef Colin J, Cochener B, Savary G, et al. Correcting keratoconus with intracorneal rings. J Cataract Refract Surg. 2000;26:1117–22.PubMedCrossRef
5.
go back to reference Snibson GR. Collagen cross-linking: a new treatment paradigm in corneal disease—a review. Clin ExperimentOphthalmol. 2010;38:141–53. Snibson GR. Collagen cross-linking: a new treatment paradigm in corneal disease—a review. Clin ExperimentOphthalmol. 2010;38:141–53.
6.
go back to reference Busin M, Scorcia V, Zambianchi L, et al. Outcomes from a modified microkeratome-assisted lamellar keratoplasty for keratoconus. Arch Ophthalmol. 2012;130:776–82.PubMedCrossRef Busin M, Scorcia V, Zambianchi L, et al. Outcomes from a modified microkeratome-assisted lamellar keratoplasty for keratoconus. Arch Ophthalmol. 2012;130:776–82.PubMedCrossRef
7.
go back to reference Burris TE. Intrastromal corneal ring technology: results and indications. Curr Opin Ophthal Mol. 1998;9:9–14.CrossRef Burris TE. Intrastromal corneal ring technology: results and indications. Curr Opin Ophthal Mol. 1998;9:9–14.CrossRef
8.
go back to reference Silvestrini T, Mathis M, Loomas B, et al. A geometric model to predict the change in corneal curvature from the intrastromal corneal ring (ICR). Invest Ophthalmol Vis Sci. 1994;35:2023. Silvestrini T, Mathis M, Loomas B, et al. A geometric model to predict the change in corneal curvature from the intrastromal corneal ring (ICR). Invest Ophthalmol Vis Sci. 1994;35:2023.
9.
go back to reference Burris TE, Baker PC, Ayer CT, et al. Flattening of central corneal curvature with intrastromal corneal rings of increasing thickness: an eye-bank eye study. J Cataract Refract Surg. 1993;19:182–7.PubMedCrossRef Burris TE, Baker PC, Ayer CT, et al. Flattening of central corneal curvature with intrastromal corneal rings of increasing thickness: an eye-bank eye study. J Cataract Refract Surg. 1993;19:182–7.PubMedCrossRef
10.
go back to reference Daxer A, Fratzl P. Collagen orientation in the human corneal stroma and its implication in keratoconus. Invest Ophthalmol Vis Sci. 1997;38:121–9.PubMed Daxer A, Fratzl P. Collagen orientation in the human corneal stroma and its implication in keratoconus. Invest Ophthalmol Vis Sci. 1997;38:121–9.PubMed
11.
go back to reference Albertazzi R. Tratamiento del queratocono con segmentos intracorneales. In: Albertazzi R, editor. Queratocono: pautas para su diagnóstico y tratamiento. Buenos Aires: Ediciones cientificas argentina para la keratoconussociety; 2010. p. 205–68. Albertazzi R. Tratamiento del queratocono con segmentos intracorneales. In: Albertazzi R, editor. Queratocono: pautas para su diagnóstico y tratamiento. Buenos Aires: Ediciones cientificas argentina para la keratoconussociety; 2010. p. 205–68.
13.
go back to reference Peña-García P, Alió JL, Vega-Estrada A, et al. Internal, corneal and refractive astigmatism as prognostic factor for ICRS implantation in mild to moderate keratoconus. J Cataract Refract Surg. 2014;40:1633–44.PubMedCrossRef Peña-García P, Alió JL, Vega-Estrada A, et al. Internal, corneal and refractive astigmatism as prognostic factor for ICRS implantation in mild to moderate keratoconus. J Cataract Refract Surg. 2014;40:1633–44.PubMedCrossRef
14.
go back to reference Giacomin NT, Mello GR, Medeiros CS, Kiliç A, Serpe CC, Almeida HG, Kara-Junior N, Santhiago MR. Intracorneal ring segments implantation for corneal ectasia. J Refract Surg. 2016;32(12):829–39.PubMedCrossRef Giacomin NT, Mello GR, Medeiros CS, Kiliç A, Serpe CC, Almeida HG, Kara-Junior N, Santhiago MR. Intracorneal ring segments implantation for corneal ectasia. J Refract Surg. 2016;32(12):829–39.PubMedCrossRef
15.
go back to reference Piñero DP, Alio JL. Intracorneal ring segments in ectatic corneal disease—a review. Clin Exp Ophthalmol. 2010;38(2):154–67.PubMedCrossRef Piñero DP, Alio JL. Intracorneal ring segments in ectatic corneal disease—a review. Clin Exp Ophthalmol. 2010;38(2):154–67.PubMedCrossRef
16.
go back to reference Colin J, Cochener B, Savary G, Malet F. Correcting keratoconus with intracorneal rings. J Cataract Refract Surg. 2000;26:1117–22.PubMedCrossRef Colin J, Cochener B, Savary G, Malet F. Correcting keratoconus with intracorneal rings. J Cataract Refract Surg. 2000;26:1117–22.PubMedCrossRef
17.
go back to reference Ertan A, Colin J. Intracorneal rings for keratoconus and keratectasia. J Cataract Refract Surg. 2007;33:1303–14.PubMedCrossRef Ertan A, Colin J. Intracorneal rings for keratoconus and keratectasia. J Cataract Refract Surg. 2007;33:1303–14.PubMedCrossRef
18.
go back to reference Ertan A, Ozkilic E. Effect of age on outcomes in patients with keratoconus treated by Intacs using a femtosecond laser. J Refract Surg. 2008;24:690–5.PubMedCrossRef Ertan A, Ozkilic E. Effect of age on outcomes in patients with keratoconus treated by Intacs using a femtosecond laser. J Refract Surg. 2008;24:690–5.PubMedCrossRef
19.
go back to reference Ertan A, Kamburoglu G. Intacs implantation using femtosecond laser for management of keratoconus: comparison of 306 cases in different stages. J Cataract Refract Surg. 2008;34:1521–6.PubMedCrossRef Ertan A, Kamburoglu G. Intacs implantation using femtosecond laser for management of keratoconus: comparison of 306 cases in different stages. J Cataract Refract Surg. 2008;34:1521–6.PubMedCrossRef
20.
go back to reference Shabayek MH, Alió JL. Intrastromal corneal ring segment implantation by femtosecond laser for keratoconus correction. Ophthalmology. 2007;114:1643–52.PubMedCrossRef Shabayek MH, Alió JL. Intrastromal corneal ring segment implantation by femtosecond laser for keratoconus correction. Ophthalmology. 2007;114:1643–52.PubMedCrossRef
21.
go back to reference Ertan A, Kamburoglu G, Bahadir M. Intacs insertion with the femtosecond laser for the management of keratoconus. One-year results. J Cataract Refract Surg. 2006;32:2039–42.PubMedCrossRef Ertan A, Kamburoglu G, Bahadir M. Intacs insertion with the femtosecond laser for the management of keratoconus. One-year results. J Cataract Refract Surg. 2006;32:2039–42.PubMedCrossRef
22.
go back to reference Ertan A, Bahadir M. Intrastromal ring segment insertion using a femtosecond laser to correct pellucid marginal corneal degeneration. J Cataract Refract Surg. 2006;32:1710–6.PubMedCrossRef Ertan A, Bahadir M. Intrastromal ring segment insertion using a femtosecond laser to correct pellucid marginal corneal degeneration. J Cataract Refract Surg. 2006;32:1710–6.PubMedCrossRef
23.
go back to reference Gatzioufas Z, Khine A, Elalfy E, Guber I, McLintock C, Sabatino F, Hamada S, Lake D. Clinical outcomes after keraring implantation for keratoconus management in patients older than 40 years: a retrospective, interventional cohort study. OphthalmolTher. 2018;7:95–100. Gatzioufas Z, Khine A, Elalfy E, Guber I, McLintock C, Sabatino F, Hamada S, Lake D. Clinical outcomes after keraring implantation for keratoconus management in patients older than 40 years: a retrospective, interventional cohort study. OphthalmolTher. 2018;7:95–100.
24.
go back to reference Zare MA, Hashemi H, Salari MR. Intracorneal ring segment implantation for the management of keratoconus: safety and efficacy. J Cataract Refract Surg. 2007;33:1886–91.PubMedCrossRef Zare MA, Hashemi H, Salari MR. Intracorneal ring segment implantation for the management of keratoconus: safety and efficacy. J Cataract Refract Surg. 2007;33:1886–91.PubMedCrossRef
25.
go back to reference Kymionis GD, Siganos CS, Tsiklis NS, et al. Long-term follow-up of Intacs in keratoconus. Am J Ophthalmol. 2007;143:236–44.PubMedCrossRef Kymionis GD, Siganos CS, Tsiklis NS, et al. Long-term follow-up of Intacs in keratoconus. Am J Ophthalmol. 2007;143:236–44.PubMedCrossRef
26.
go back to reference Alió JL, Shabayek MH, Artola A. Intracorneal ring segments for keratoconus correction: long-term follow-up. J Cataract Refract Surg. 2006;32:978–85.PubMedCrossRef Alió JL, Shabayek MH, Artola A. Intracorneal ring segments for keratoconus correction: long-term follow-up. J Cataract Refract Surg. 2006;32:978–85.PubMedCrossRef
27.
go back to reference Alió JL, Shabayek MH, Belda JI, Correas P, Diez Feijoo E. Analysis of results related to good and bad outcomes of Intacs implantation for keratoconus correction. J Cataract Refract Surg. 2006;32:756–61.PubMedCrossRef Alió JL, Shabayek MH, Belda JI, Correas P, Diez Feijoo E. Analysis of results related to good and bad outcomes of Intacs implantation for keratoconus correction. J Cataract Refract Surg. 2006;32:756–61.PubMedCrossRef
28.
go back to reference Colin J. European clinical evaluation: use of Intacs for the treatment of keratoconus. J Cataract Refract Surg. 2006;32:747–55.PubMedCrossRef Colin J. European clinical evaluation: use of Intacs for the treatment of keratoconus. J Cataract Refract Surg. 2006;32:747–55.PubMedCrossRef
29.
go back to reference Kanellopoulos AJ, Pe LH, Perry HD, Donnenfeld ED. Modified intracorneal ring segment implantations (Intacs) for the management of moderate to advanced keratoconus. Efficacy and complications. Cornea. 2006;25:29–33.PubMedCrossRef Kanellopoulos AJ, Pe LH, Perry HD, Donnenfeld ED. Modified intracorneal ring segment implantations (Intacs) for the management of moderate to advanced keratoconus. Efficacy and complications. Cornea. 2006;25:29–33.PubMedCrossRef
30.
go back to reference Hellstedt T, Mäkelä J, Uusitalo R, Emre S, Uusitalo R. Treating keratoconus with Intacs corneal ring segments. J Refract Surg. 2005;21:236–46.PubMedCrossRef Hellstedt T, Mäkelä J, Uusitalo R, Emre S, Uusitalo R. Treating keratoconus with Intacs corneal ring segments. J Refract Surg. 2005;21:236–46.PubMedCrossRef
31.
go back to reference Kwitko S, Severo NS. Ferrara intracorneal ring segments for keratoconus. J Cataract Refract Surg. 2004;30:812–20.PubMedCrossRef Kwitko S, Severo NS. Ferrara intracorneal ring segments for keratoconus. J Cataract Refract Surg. 2004;30:812–20.PubMedCrossRef
32.
go back to reference Miranda D, Sartori M, Francesconi C, Allemann N, Ferrara P, Campos M. Ferrara intrastromal corneal ring segments for severe keratoconus. J Refract Surg. 2003;19:645–53.PubMedCrossRef Miranda D, Sartori M, Francesconi C, Allemann N, Ferrara P, Campos M. Ferrara intrastromal corneal ring segments for severe keratoconus. J Refract Surg. 2003;19:645–53.PubMedCrossRef
33.
go back to reference Siganos CS, Kymionis GD, Kartakis N, Theodorakis MA, Astyrakakis N, Pallikaris IG. Management of keratoconus with Intacs. Am J Ophthalmol. 2003;135:64–70.PubMedCrossRef Siganos CS, Kymionis GD, Kartakis N, Theodorakis MA, Astyrakakis N, Pallikaris IG. Management of keratoconus with Intacs. Am J Ophthalmol. 2003;135:64–70.PubMedCrossRef
34.
go back to reference Boxer Wachler BS, Chandra NS, Chou B, Korn TS, Nepomuceno R, Christie JP. Intacs for keratoconus. Ophthalmology. 2003;110:1031–40.PubMedCrossRef Boxer Wachler BS, Chandra NS, Chou B, Korn TS, Nepomuceno R, Christie JP. Intacs for keratoconus. Ophthalmology. 2003;110:1031–40.PubMedCrossRef
35.
go back to reference Ruckhofer J, Stoiber J, Twa MD, Grabner G. Correction of astigmatism with short arc-length intrastromal corneal ring segments. Ophthalmology. 2003;110:516–24.PubMedCrossRef Ruckhofer J, Stoiber J, Twa MD, Grabner G. Correction of astigmatism with short arc-length intrastromal corneal ring segments. Ophthalmology. 2003;110:516–24.PubMedCrossRef
36.
go back to reference Ertan A, Bahadir M. Management of superior pellucid marginal degeneration with a single intracorneal ring segment using femtosecond laser. J Refract Surg. 2007;23:205–8.PubMedCrossRef Ertan A, Bahadir M. Management of superior pellucid marginal degeneration with a single intracorneal ring segment using femtosecond laser. J Refract Surg. 2007;23:205–8.PubMedCrossRef
37.
go back to reference Mularoni A, Torreggiani A, Di Biase A, Laffi GL, Tassinari G. Conservative treatment of early and moderate pellucid marginal degeneration: a new refractive approach with intracorneal rings. Ophthalmology. 2005;112:660–6.PubMedCrossRef Mularoni A, Torreggiani A, Di Biase A, Laffi GL, Tassinari G. Conservative treatment of early and moderate pellucid marginal degeneration: a new refractive approach with intracorneal rings. Ophthalmology. 2005;112:660–6.PubMedCrossRef
38.
go back to reference Barbara A, Shehadeh-Mashaour R, Zvi R, Garzozi HJ. Management of pellucid marginal degeneration with intracorneal ring segments. J Refract Surg. 2005;21:296–8.PubMedCrossRef Barbara A, Shehadeh-Mashaour R, Zvi R, Garzozi HJ. Management of pellucid marginal degeneration with intracorneal ring segments. J Refract Surg. 2005;21:296–8.PubMedCrossRef
39.
go back to reference Akaishi L, Tzelikis PF, Raber IM. Ferrara intracorneal ring implantation and cataract surgery for the correction of pellucid marginal corneal degeneration. J Cataract Refract Surg. 2004;30:2427–30.PubMedCrossRef Akaishi L, Tzelikis PF, Raber IM. Ferrara intracorneal ring implantation and cataract surgery for the correction of pellucid marginal corneal degeneration. J Cataract Refract Surg. 2004;30:2427–30.PubMedCrossRef
40.
go back to reference Kymionis GD, Aslanides IM, Siganos CS, Pallikaris IG. Intacs for early pellucid marginal degeneration. J Cataract Refract Surg. 2004;30:230–3.PubMedCrossRef Kymionis GD, Aslanides IM, Siganos CS, Pallikaris IG. Intacs for early pellucid marginal degeneration. J Cataract Refract Surg. 2004;30:230–3.PubMedCrossRef
41.
go back to reference Rodriguez-Prats J, Galal A, Garcia-Lledo M, De la Hoz F, Alió JL. Intracorneal rings for the correction of pellucid marginal degeneration. J Cataract Refract Surg. 2003;29:1421–4.PubMedCrossRef Rodriguez-Prats J, Galal A, Garcia-Lledo M, De la Hoz F, Alió JL. Intracorneal rings for the correction of pellucid marginal degeneration. J Cataract Refract Surg. 2003;29:1421–4.PubMedCrossRef
42.
go back to reference Polkroy R, Levinger S, Hirsh A. Single Intacs segment for post-laser in situ keratomileusis keratectasia. J Cataract Refract Surg. 2004;30:1685–95.CrossRef Polkroy R, Levinger S, Hirsh A. Single Intacs segment for post-laser in situ keratomileusis keratectasia. J Cataract Refract Surg. 2004;30:1685–95.CrossRef
43.
go back to reference Güell JL, Velasco F, Sánchez SI, Gris O, García-Rojas M. Intracorneal ring segments after laser in situ keratomileusis. J Refract Surg. 2004;20:349–55.PubMedCrossRef Güell JL, Velasco F, Sánchez SI, Gris O, García-Rojas M. Intracorneal ring segments after laser in situ keratomileusis. J Refract Surg. 2004;20:349–55.PubMedCrossRef
44.
go back to reference Alió JL, Artola A, Hassanein A, Haroun H, Galal A. One or 2 Intacs segments for the correction of keratoconus. J Cataract Refract Surg. 2005;31:943–53.PubMedCrossRef Alió JL, Artola A, Hassanein A, Haroun H, Galal A. One or 2 Intacs segments for the correction of keratoconus. J Cataract Refract Surg. 2005;31:943–53.PubMedCrossRef
45.
go back to reference Carrasquillo KG, Rand J, Talamo JH. Intacs for keratoconus and post-LASIK ectasia: mechanical versus femtosecond laser-assisted channel creation. Cornea. 2007;26:956–62.PubMedCrossRef Carrasquillo KG, Rand J, Talamo JH. Intacs for keratoconus and post-LASIK ectasia: mechanical versus femtosecond laser-assisted channel creation. Cornea. 2007;26:956–62.PubMedCrossRef
46.
go back to reference Rabinowitz YS, Li X, Ignacio TS, Maguen E. Intacs inserts using the femtosecond laser compared to the mechanical spreader in the treatment of keratoconus. J Refract Surg. 2006;22:764–71.PubMedCrossRef Rabinowitz YS, Li X, Ignacio TS, Maguen E. Intacs inserts using the femtosecond laser compared to the mechanical spreader in the treatment of keratoconus. J Refract Surg. 2006;22:764–71.PubMedCrossRef
47.
go back to reference Kymionis GD, Siganos CS, Kounis G, Astyrakakis N, Kalyvianaki MI, Pallikaris IG. Management of post- LASIK corneal ectasia with Intacs inserts. One-year results. Arch Ophthalmol. 2003;121:322–6.PubMedCrossRef Kymionis GD, Siganos CS, Kounis G, Astyrakakis N, Kalyvianaki MI, Pallikaris IG. Management of post- LASIK corneal ectasia with Intacs inserts. One-year results. Arch Ophthalmol. 2003;121:322–6.PubMedCrossRef
48.
go back to reference Vega-Estrada A, Alió JL. The use of intracorneal ring segments in keratoconus. Eye Vis. 2016;3:8.CrossRef Vega-Estrada A, Alió JL. The use of intracorneal ring segments in keratoconus. Eye Vis. 2016;3:8.CrossRef
49.
go back to reference Shetty R, Kurian M, Anand D, Mhaske P, Narayana KM, Shetty BK. Intacs in advanced keratoconus. Cornea. 2008;27:1022–9.PubMedCrossRef Shetty R, Kurian M, Anand D, Mhaske P, Narayana KM, Shetty BK. Intacs in advanced keratoconus. Cornea. 2008;27:1022–9.PubMedCrossRef
50.
go back to reference Chan CC, Sharma M, Wachler BS. Effect of inferior-segment Intacs with and without C3-R on keratoconus. J Cataract Refract Surg. 2007;33:75–80.PubMedCrossRef Chan CC, Sharma M, Wachler BS. Effect of inferior-segment Intacs with and without C3-R on keratoconus. J Cataract Refract Surg. 2007;33:75–80.PubMedCrossRef
51.
go back to reference Colin J, Cochener B, Savary G, Malet F, Holmes- Higgin D. Intacs inserts for treating keratoconus. One year results. Ophthalmology. 2001;108:1409–14.PubMedCrossRef Colin J, Cochener B, Savary G, Malet F, Holmes- Higgin D. Intacs inserts for treating keratoconus. One year results. Ophthalmology. 2001;108:1409–14.PubMedCrossRef
52.
go back to reference Alfonso JF, Lisa C, Merayo-Lloves J, Fernández-Vega Cueto L, Montés-Micó R. Intrastromal corneal ring segment implantation in paracentral keratoconus with coincident topographic and coma axis. J Cataract Refract Surg. 2012;38(9):1576–82.PubMedCrossRef Alfonso JF, Lisa C, Merayo-Lloves J, Fernández-Vega Cueto L, Montés-Micó R. Intrastromal corneal ring segment implantation in paracentral keratoconus with coincident topographic and coma axis. J Cataract Refract Surg. 2012;38(9):1576–82.PubMedCrossRef
53.
go back to reference Peña-García P, Alió JL, Vega-Estrada A, Barraquer RI. Internal, corneal, and refractive astigmatism as prognostic factors for intrastromal corneal ring segment implantation in mild to moderate keratoconus. J Cataract Refract Surg. 2014;40(10):1633–44.PubMedCrossRef Peña-García P, Alió JL, Vega-Estrada A, Barraquer RI. Internal, corneal, and refractive astigmatism as prognostic factors for intrastromal corneal ring segment implantation in mild to moderate keratoconus. J Cataract Refract Surg. 2014;40(10):1633–44.PubMedCrossRef
54.
go back to reference Sharma M, Wachler BSB. Comparison of single segment and double-segment Intacs for keratoconus and post-LASIK ectasia. Am J Ophthalmol. 2006;141:891–5.PubMedCrossRef Sharma M, Wachler BSB. Comparison of single segment and double-segment Intacs for keratoconus and post-LASIK ectasia. Am J Ophthalmol. 2006;141:891–5.PubMedCrossRef
55.
go back to reference Coskunseven E, Kymionis GD, Tsiklis NS, et al. Oneyear results of intrastromal corneal ring segment implantation (KeraRing) using femtosecond laser in patients with keratoconus. Am J Ophthalmol. 2008;145:775–9.PubMedCrossRef Coskunseven E, Kymionis GD, Tsiklis NS, et al. Oneyear results of intrastromal corneal ring segment implantation (KeraRing) using femtosecond laser in patients with keratoconus. Am J Ophthalmol. 2008;145:775–9.PubMedCrossRef
56.
go back to reference Siganos D, Ferrara P, Chatzinikolas K, Bessis N, Papastergiou G. Ferrara intrastromal corneal rings for the correction of keratoconus. J Cataract Refract Surg. 2002;28:1947–51.PubMedCrossRef Siganos D, Ferrara P, Chatzinikolas K, Bessis N, Papastergiou G. Ferrara intrastromal corneal rings for the correction of keratoconus. J Cataract Refract Surg. 2002;28:1947–51.PubMedCrossRef
57.
go back to reference Colin J, Malet FJ. Intacs for the correction of keratoconus: two-year follow-up. J Cataract Refract Surg. 2007;33(1):69–74.PubMedCrossRef Colin J, Malet FJ. Intacs for the correction of keratoconus: two-year follow-up. J Cataract Refract Surg. 2007;33(1):69–74.PubMedCrossRef
58.
go back to reference Silvestrini TA, Mathis ML, Loomas BE, Burris TE. A geometric model to predict the change in corneal curvature from the intrastromal corneal ring (ICR). Investig Ophthalmol Vis Sci. 1994;35:2023. Silvestrini TA, Mathis ML, Loomas BE, Burris TE. A geometric model to predict the change in corneal curvature from the intrastromal corneal ring (ICR). Investig Ophthalmol Vis Sci. 1994;35:2023.
59.
go back to reference Kaya V, Utine CA, Karakus SH, Kavadarli I, Yilmaz OF. Refractive and visual outcomes after Intacs vs ferrara intrastromal corneal ring segment implantation for keratoconus: a comparative study. J Refract Surg. 2011;27(12):907–12.PubMedCrossRef Kaya V, Utine CA, Karakus SH, Kavadarli I, Yilmaz OF. Refractive and visual outcomes after Intacs vs ferrara intrastromal corneal ring segment implantation for keratoconus: a comparative study. J Refract Surg. 2011;27(12):907–12.PubMedCrossRef
60.
go back to reference Gatzioufas Z, Panos GD, Elalfy M, Khine A, Hamada S, Lake D, Kozeis N, Balidis M. Effect of conus eccentricity on visual outcomes after intracorneal ring segments implantation in keratoconus. J Refract Surg. 2018;34(3):196–200.PubMedCrossRef Gatzioufas Z, Panos GD, Elalfy M, Khine A, Hamada S, Lake D, Kozeis N, Balidis M. Effect of conus eccentricity on visual outcomes after intracorneal ring segments implantation in keratoconus. J Refract Surg. 2018;34(3):196–200.PubMedCrossRef
61.
go back to reference Vega-Estrada A, Alio JL, Brenner LF, Javaloy J, Plaza Puche AB, Barraquer RI, et al. Outcome analysis of intracorneal ring segments for the treatment of keratoconus based on visual, refractive, and aberrometric impairment. Am J Ophthalmol. 2013;155(3):575–84.PubMedCrossRef Vega-Estrada A, Alio JL, Brenner LF, Javaloy J, Plaza Puche AB, Barraquer RI, et al. Outcome analysis of intracorneal ring segments for the treatment of keratoconus based on visual, refractive, and aberrometric impairment. Am J Ophthalmol. 2013;155(3):575–84.PubMedCrossRef
62.
go back to reference Vega-Estrada A, Alió JL, Brenner LF, Burguera N. Outcomes of intrastromal corneal ring segments for treatment of keratoconus: five-year follow-up analysis. J Cataract Refract Surg. 2013;39:1234–40.PubMedCrossRef Vega-Estrada A, Alió JL, Brenner LF, Burguera N. Outcomes of intrastromal corneal ring segments for treatment of keratoconus: five-year follow-up analysis. J Cataract Refract Surg. 2013;39:1234–40.PubMedCrossRef
64.
go back to reference Niknam S, Shamshiri M, Shahrzad SS, Alipour A, Rajabi MB, Rajabi MT. Treatment of moderate to severe keratoconus with 6-mm Intacs SK. Int J Ophthalmol. 2012;5(4):513–6.PubMedPubMedCentral Niknam S, Shamshiri M, Shahrzad SS, Alipour A, Rajabi MB, Rajabi MT. Treatment of moderate to severe keratoconus with 6-mm Intacs SK. Int J Ophthalmol. 2012;5(4):513–6.PubMedPubMedCentral
65.
go back to reference Abad JC, Arango J, Tobon C. Comparison of astigmatism correction using shorter arc length 90°/120° asymmetric intacs severe keratoconus versus 150° single-segment intacs severe keratoconus in asymmetric keratoconus. Cornea. 2011;30(11):1201–6.PubMedCrossRef Abad JC, Arango J, Tobon C. Comparison of astigmatism correction using shorter arc length 90°/120° asymmetric intacs severe keratoconus versus 150° single-segment intacs severe keratoconus in asymmetric keratoconus. Cornea. 2011;30(11):1201–6.PubMedCrossRef
66.
go back to reference Levinger S, Pokroy R. Keratoconus managed with Intacs: one-year results. Arch Ophthalmol. 2005;123(10):1308–14.PubMedCrossRef Levinger S, Pokroy R. Keratoconus managed with Intacs: one-year results. Arch Ophthalmol. 2005;123(10):1308–14.PubMedCrossRef
67.
go back to reference Ertan A, Kamburoğlu G, Akgόn U. Comparison of outcomes of 2 channel sizes for intrastromal ring segment implantation with a femtosecond laser in eyes with keratoconus. J Cataract Refract Surg. 2007;33(4):648–53.PubMedCrossRef Ertan A, Kamburoğlu G, Akgόn U. Comparison of outcomes of 2 channel sizes for intrastromal ring segment implantation with a femtosecond laser in eyes with keratoconus. J Cataract Refract Surg. 2007;33(4):648–53.PubMedCrossRef
68.
go back to reference Alió JL, Piñero DP, Alesón A, Teus MA, Barraquer RI, Murta J, et al. Keratoconus-integrated characterization considering anterior corneal aberrations, internal astigmatism, and corneal biomechanics. J Cataract Refract Surg. 2011;37:552–68.PubMedCrossRef Alió JL, Piñero DP, Alesón A, Teus MA, Barraquer RI, Murta J, et al. Keratoconus-integrated characterization considering anterior corneal aberrations, internal astigmatism, and corneal biomechanics. J Cataract Refract Surg. 2011;37:552–68.PubMedCrossRef
69.
go back to reference Kymionis GD, Tsiklis NS, Pallikaris AI, et al. Long-term follow-up of Intacs for post-LASIK corneal ectasia. Ophthalmology. 2006;113:1909–17.PubMedCrossRef Kymionis GD, Tsiklis NS, Pallikaris AI, et al. Long-term follow-up of Intacs for post-LASIK corneal ectasia. Ophthalmology. 2006;113:1909–17.PubMedCrossRef
70.
go back to reference Torquetti L, Berbel RF, Ferrara P. Long-term follow-up of intrastromal corneal ring segments in keratoconus. J Cataract Refract Surg. 2009;35(10):1768–73.PubMedCrossRef Torquetti L, Berbel RF, Ferrara P. Long-term follow-up of intrastromal corneal ring segments in keratoconus. J Cataract Refract Surg. 2009;35(10):1768–73.PubMedCrossRef
71.
go back to reference Piρero DP, Aliσ JL, El Kady B, Pascual I. Intracorneal ring segment implantation in corneas with post-laser in situ keratomileusis keratectasia. J Cataract Refract Surg. 2010;36(1):102–9. Piρero DP, Aliσ JL, El Kady B, Pascual I. Intracorneal ring segment implantation in corneas with post-laser in situ keratomileusis keratectasia. J Cataract Refract Surg. 2010;36(1):102–9.
72.
go back to reference Piρero DP, Alio JL, El Kady B, Coskunseven E, Morbelli H, Uceda-Montanes A, Maldonado MJ, Cuevas D, Pascual I. Refractive and aberrometric outcomes of intracorneal ring segments for keratoconus: mechanical versus femtosecond-assisted procedures. Ophthalmology. 2009;116(9):1675–87.CrossRef Piρero DP, Alio JL, El Kady B, Coskunseven E, Morbelli H, Uceda-Montanes A, Maldonado MJ, Cuevas D, Pascual I. Refractive and aberrometric outcomes of intracorneal ring segments for keratoconus: mechanical versus femtosecond-assisted procedures. Ophthalmology. 2009;116(9):1675–87.CrossRef
73.
go back to reference Kymionis GD, Grentzelos MA, Diakonis VF, Pallikaris AI, Pallikaris IG. Nine-year follow-up of intacs implantation for keratoconus. Open Ophthalmol J. 2009;3:77–81.PubMedPubMedCentralCrossRef Kymionis GD, Grentzelos MA, Diakonis VF, Pallikaris AI, Pallikaris IG. Nine-year follow-up of intacs implantation for keratoconus. Open Ophthalmol J. 2009;3:77–81.PubMedPubMedCentralCrossRef
74.
go back to reference Vega-Estrada A, Alió JL, Plaza-Puche AB. Keratoconus progression after intrastromal corneal ring segment implantation in young patients: Five-year follow-up. J Cataract Refract Surg. 2015;41(6):1145–52.PubMedCrossRef Vega-Estrada A, Alió JL, Plaza-Puche AB. Keratoconus progression after intrastromal corneal ring segment implantation in young patients: Five-year follow-up. J Cataract Refract Surg. 2015;41(6):1145–52.PubMedCrossRef
75.
go back to reference Saelens IE, Bartels MC, Bleyen I, Van Rij G. Refractive, topographic, and visual outcomes of same-day corneal cross-linking with Ferrara intracorneal ring segments in patients with progressive keratoconus. Cornea. 2011;30:1406–8.PubMedCrossRef Saelens IE, Bartels MC, Bleyen I, Van Rij G. Refractive, topographic, and visual outcomes of same-day corneal cross-linking with Ferrara intracorneal ring segments in patients with progressive keratoconus. Cornea. 2011;30:1406–8.PubMedCrossRef
76.
go back to reference Kılıç A, Kamburoglu G, Akıncı A. Riboflavin injection into the corneal channel for combined collagen crosslinking and intrastromal corneal ring segment implantation. J Cataract Refract Surg. 2012;38:878–83.PubMedCrossRef Kılıç A, Kamburoglu G, Akıncı A. Riboflavin injection into the corneal channel for combined collagen crosslinking and intrastromal corneal ring segment implantation. J Cataract Refract Surg. 2012;38:878–83.PubMedCrossRef
77.
go back to reference Alió JL, Artola A, Ruiz-Moreno JM, et al. Changes in keratoconic corneas after intracorneal ring segment explantation and reimplantation. Ophthalmology. 2004;111:747–51.PubMedCrossRef Alió JL, Artola A, Ruiz-Moreno JM, et al. Changes in keratoconic corneas after intracorneal ring segment explantation and reimplantation. Ophthalmology. 2004;111:747–51.PubMedCrossRef
78.
go back to reference Ferrer C, Alio IJMA, et al. Causes of intrastromal corneal ring segment explantation: clinicopathologic correlation analysis. J Cataract Refract Surg. 2010;36(6):970–7.PubMedCrossRef Ferrer C, Alio IJMA, et al. Causes of intrastromal corneal ring segment explantation: clinicopathologic correlation analysis. J Cataract Refract Surg. 2010;36(6):970–7.PubMedCrossRef
79.
go back to reference Coskunseven E, Kymionis G, Tsiklis N, Arslan S, Siganos C, Jankov M, Pallikaris I. Complications of intrastromal corneal ring segment implantation using a femtosecond laser for channel creation: a survey of 850 eyes with keratoconus. Acta Ophthalmol. 2011;89:54–7.PubMedCrossRef Coskunseven E, Kymionis G, Tsiklis N, Arslan S, Siganos C, Jankov M, Pallikaris I. Complications of intrastromal corneal ring segment implantation using a femtosecond laser for channel creation: a survey of 850 eyes with keratoconus. Acta Ophthalmol. 2011;89:54–7.PubMedCrossRef
80.
go back to reference Giacomin NT, Mello GR, Medeiros CS, Kiliç A, Serpe CC, Almeida HG, Kara-Junior N, Santhiago MR. Intracorneal ring segments implantation for corneal ectasia. J Refract Surg. 2016;32(12):829–39.PubMedCrossRef Giacomin NT, Mello GR, Medeiros CS, Kiliç A, Serpe CC, Almeida HG, Kara-Junior N, Santhiago MR. Intracorneal ring segments implantation for corneal ectasia. J Refract Surg. 2016;32(12):829–39.PubMedCrossRef
81.
go back to reference Yeung SN, Lichtinger A, Ku JYF, Kim P, Low SAW, Rootman DS. Intracorneal ring segment explantation after intracorneal ring segment implantation combined with same-day corneal collagen crosslinking in keratoconus. Cornea. 2013;32:1617–20.PubMedCrossRef Yeung SN, Lichtinger A, Ku JYF, Kim P, Low SAW, Rootman DS. Intracorneal ring segment explantation after intracorneal ring segment implantation combined with same-day corneal collagen crosslinking in keratoconus. Cornea. 2013;32:1617–20.PubMedCrossRef
82.
go back to reference Flecha-Lescún J, Calvo B, Zurita J, Ariza-Gracia MÁ. Template-based methodology for the simulation of intracorneal segment ring implantation in human corneas. Biomech Model Mechanobiol. 2018;17(4):923–38.PubMedCrossRef Flecha-Lescún J, Calvo B, Zurita J, Ariza-Gracia MÁ. Template-based methodology for the simulation of intracorneal segment ring implantation in human corneas. Biomech Model Mechanobiol. 2018;17(4):923–38.PubMedCrossRef
Metadata
Title
Intracorneal Ring Segment Implantation in the Management of Keratoconus: An Evidence-Based Approach
Authors
Dimitris Sakellaris
Miltos Balidis
Olga Gorou
Nora Szentmary
Antonios Alexoudis
Matthias C. Grieshaber
Despoina Sagri
Hendrik Scholl
Zisis Gatzioufas
Publication date
01-10-2019
Publisher
Springer Healthcare
Published in
Ophthalmology and Therapy / Issue Special Issue 1/2019
Print ISSN: 2193-8245
Electronic ISSN: 2193-6528
DOI
https://doi.org/10.1007/s40123-019-00211-2
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.