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Archives of Orthopaedic and Trauma Surgery
Published in: Archives of Orthopaedic and Trauma Surgery 12/2011

01-12-2011 | Orthopaedic Outcome Assessment

Intra-articular injection of hyaluronic acid (MW 1,500–2,000 kDa; HyalOne®) in symptomatic osteoarthritis of the hip: a prospective cohort study

Authors: Migliore Alberto, Massafra Umberto, Bizzi Emanuele, Laganà Bruno, Germano Valentina, Piscitelli Prisco, Granata Mauro, Tormenta Sandro

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 12/2011

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Abstract

Introduction

Clinical trials have demonstrated the safety and efficacy of hyaluronic acid-based products for the treatment of hip osteoarthritis, but data from observational studies of normal medical practice are scarce. This study investigated the long-term efficacy and tolerability of ultrasound-guided intra-articular sodium hyaluronate (MW 1,500–2,000 kDa; Hyalone®) injections in daily clinical practice.

Methods

In this observational, cohort study of patients with hip osteoarthritis, Hyalone® was administered under the ultrasound guidance, every 6 months, with the possibility of an additional injection at the intervening 3-month intervals on clinical request. Efficacy measurements included the Lequesne algofunctional index, self-reported pain via the visual analogue scale (VAS), the concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs) and safety. The patients were followed up for 18 months after the first intra-articular injection.

Results

Data from 120 patients were collected. During the study, a statistically significant reduction in algofunctional indexes was demonstrated at 3 months after study product injection, while at 12 months 80% of the patients achieved a decrease of at least 30% in symptoms. These results were maintained over time through cyclical and personalized repetition of ultrasound guided injections, at least one injection every 6 months.

Conclusions

The study treatment reduced pain and improved mobility in osteoarthritis of the hip. These results in daily clinical practice demonstrate a beneficial effect and the safety of the study product and suggest adding intra-articular injections of HyalOne® to the armamentarium of conservative management of symptomatic hip osteoarthritis.
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Metadata
Title
Intra-articular injection of hyaluronic acid (MW 1,500–2,000 kDa; HyalOne®) in symptomatic osteoarthritis of the hip: a prospective cohort study
Authors
Migliore Alberto
Massafra Umberto
Bizzi Emanuele
Laganà Bruno
Germano Valentina
Piscitelli Prisco
Granata Mauro
Tormenta Sandro
Publication date
01-12-2011
Publisher
Springer-Verlag
Published in
Archives of Orthopaedic and Trauma Surgery / Issue 12/2011
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI
https://doi.org/10.1007/s00402-011-1353-y

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