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01-09-2015 | Editorial

Intra-abdominal candidiasis: it’s still a long way to get unquestionable data

Authors: Philippe Montravers, Olivier Leroy, Christian Eckmann

Published in: Intensive Care Medicine | Issue 9/2015

Excerpt

Intra-abdominal candidiasis (IAC) appears as the second most frequent cause of invasive fungal infection in the intensive-care unit (ICU) [1]. In the AmarCand 1 study, a prospective, multicenter, French observational study, IAC was observed in 34 % of ICU patients with proven invasive candidiasis [1]. Intra-abdominal candidiasis accounts for more than 10 % of all cases of peritonitis and is associated with mortality rates between 25 and 60 % [2, 3]. …

Leroy O, Gangneux JP, Montravers P, Mira JP, Gouin F, Sollet JP, Carlet J, Reynes J, Rosenheim M, Regnier B, Lortholary O (2009) Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: a multicenter, prospective, observational study in France (2005–2006). Crit Care Med 37(5):1612–1618. doi:10.1097/CCM.0b013e31819efac0 CrossRefPubMed

Dupont H, Paugam-Burtz C, Muller-Serieys C, Fierobe L, Chosidow D, Marmuse JP, Mantz J, Desmonts JM, Desmonts JM (2002) Predictive factors of mortality due to polymicrobial peritonitis with Candida isolation in peritoneal fluid in critically ill patients. Arch Surg 137(12):1341–1346CrossRefPubMed

Montravers P, Dupont H, Gauzit R, Veber B, Auboyer C, Blin P, Hennequin C, Martin C (2006) Candida as a risk factor for mortality in peritonitis. Crit Care Med 34(3):646–652CrossRefPubMed

Guery BP, Arendrup MC, Auzinger G, Azoulay E, Borges Sa M, Johnson EM, Muller E, Putensen C, Rotstein C, Sganga G, Venditti M, Zaragoza Crespo R, Kullberg BJ (2009) Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: part I epidemiology and diagnosis. Intensive Care Med 35(1):55–62. doi:10.1007/s00134-008-1338-7 CrossRefPubMed

Montravers P, Mira JP, Gangneux JP, Leroy O, Lortholary O (2011) A multicentre study of antifungal strategies and outcome of Candida spp. peritonitis in intensive-care units. Clin Microbiol Infect 17(7):1061–1067. doi:10.1111/j.1469-0691.2010.03360.x CrossRefPubMed

Solomkin JS, Mazuski JE, Bradley JS, Rodvold KA, Goldstein EJ, Baron EJ, O’Neill PJ, Chow AW, Dellinger EP, Eachempati SR, Gorbach S, Hilfiker M, May AK, Nathens AB, Sawyer RG, Bartlett JG (2010) Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin Infect Dis 50(2):133–164. doi:10.1086/649554 CrossRefPubMed

Bassetti M, Marchetti M, Chakrabarti A, Colizza S, Garnacho-Montero J, Kett DH, Munoz P, Cristini F, Andoniadou A, Viale P, Rocca GD, Roilides E, Sganga G, Walsh TJ, Tascini C, Tumbarello M, Menichetti F, Righi E, Eckmann C, Viscoli C, Shorr AF, Leroy O, Petrikos G, De Rosa FG (2013) A research agenda on the management of intra-abdominal candidiasis: results from a consensus of multinational experts. Intensive Care Med 39(12):2092–2106. doi:10.1007/s00134-013-3109-3 CrossRefPubMed

Bassetti M, Righi E, Ansaldi F, Merelli M, Scarparo C, Antonelli M, Garnacho-Montero J, Diaz-Martin A, Palacios-Garcia I, Luzzati R, Rosin C, Lagunes L, Rello J, Almirante B, Scotton PG, Baldin G, Dimopoulos G, Nucci M, Munoz P, Vena A, Bouza E, de Egea V, Colombo AL, Tascini C, Menichetti F, Tagliaferri E, Brugnaro P, Sanguinetti M, Mesini A, Sganga G, Viscoli C, Tumbarello M (2015) A multicenter multinational study of abdominal candidiasis: epidemiology, outcomes and predictors of mortality. Intensive Care Med. doi:10.1007/s00134-015-3866-2

Bassetti M, Righi E, Ansaldi F, Merelli M, Trucchi C, De Pascale G, Diaz-Martin A, Luzzati R, Rosin C, Lagunes L, Trecarichi EM, Sanguinetti M, Posteraro B, Garnacho-Montero J, Sartor A, Rello J, Rocca GD, Antonelli M, Tumbarello M (2014) A multicenter study of septic shock due to candidemia: outcomes and predictors of mortality. Intensive Care Med 40(6):839–845. doi:10.1007/s00134-014-3310-z CrossRefPubMed

10.

Solomkin JS, Ristagno RL, Das AF, Cone JB, Wilson SE, Rotstein OD, Murphy BS, Severin KS, Bruss JB (2013) Source control review in clinical trials of anti-infective agents in complicated intra-abdominal infections. Clin Infect Dis 56(12):1765–1773. doi:10.1093/cid/cit128 CrossRefPubMed

11.

Calandra T, Marchetti O (2004) Clinical trials of antifungal prophylaxis among patients undergoing surgery. Clin Infect Dis 39(Suppl 4):S185–S192. doi:10.1086/421955 CrossRefPubMed

12.

Tissot F, Lamoth F, Hauser PM, Orasch C, Fluckiger U, Siegemund M, Zimmerli S, Calandra T, Bille J, Eggimann P, Marchetti O (2013) beta-glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis. Am J Respir Crit Care Med 188(9):1100–1109. doi:10.1164/rccm.201211-2069OC CrossRefPubMed

13.

Leon C, Ruiz-Santana S, Saavedra P, Castro C, Ubeda A, Loza A, Martin-Mazuelos E, Blanco A, Jerez V, Ballus J, Alvarez-Rocha L, Utande-Vazquez A, Farinas O (2012) Value of beta-D-glucan and Candida albicans germ tube antibody for discriminating between Candida colonization and invasive candidiasis in patients with severe abdominal conditions. Intensive Care Med 38(8):1315–1325. doi:10.1007/s00134-012-2616-y CrossRefPubMed

14.

Eckmann C, Sanchez-Garcia M (2013) Monitoring treatment response in abdominal sepsis with procalcitonin–if only! Crit Care 17(6):1017. doi:10.1186/cc13154 PubMedCentralCrossRefPubMed

Title: Intra-abdominal candidiasis: it’s still a long way to get unquestionable data
Authors: Philippe Montravers
Olivier Leroy
Christian Eckmann
Publication date: 01-09-2015
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 9/2015
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-015-3894-y

At a glance: The STEP trials

Springer Medicine

Intra-abdominal candidiasis: it’s still a long way to get unquestionable data

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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