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Journal of Gastroenterology
Published in: Journal of Gastroenterology 5/2015

01-05-2015 | Review

Intestinal and hepatic drug transporters: pharmacokinetic, pathophysiological, and pharmacogenetic roles

Authors: Tomohiro Terada, Daiki Hira

Published in: Journal of Gastroenterology | Issue 5/2015

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Abstract

The efficacy and safety of pharmacotherapies are determined by the complex processes involved in the interactions between drugs with the human body, including pharmacokinetic aspects. Among pharmacokinetic factors, it has been recognized that drug transporters play critical roles for absorption, distribution and excretion of drugs, regulating the membrane transport of drugs. The vast amounts of information on drug transporters collected in the past 20 years have been organized according to biochemical, molecular, genetic, and clinical analyses. Novel technologies, public databases, and regulatory guidelines have advanced the use of such information in drug development and clinical practice. In this review, we selected some clinically important drug transporters expressed in the intestine and liver, and introduced the research history and current knowledge of their pharmacokinetic, pathophysiological, and pharmacogenetic implications.
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Metadata
Title
Intestinal and hepatic drug transporters: pharmacokinetic, pathophysiological, and pharmacogenetic roles
Authors
Tomohiro Terada
Daiki Hira
Publication date
01-05-2015
Publisher
Springer Japan
Published in
Journal of Gastroenterology / Issue 5/2015
Print ISSN: 0944-1174
Electronic ISSN: 1435-5922
DOI
https://doi.org/10.1007/s00535-015-1061-4

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