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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2004

01-11-2004 | Commentary

Interleukin-18: a therapeutic target in rheumatoid arthritis?

Authors: Iain B McInnes, Foo Y Liew, J Alastair Gracie

Published in: Arthritis Research & Therapy | Issue 1/2004

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Abstract

Interleukin 18 (IL-18), a member of the IL-1 superfamily of cytokines has been demonstrated to be an important mediator of both innate and adaptive immune responses. Several reports have implicated its role in the pathogenesis of rheumatoid arthritis (RA). Although biologic therapy is firmly established in the treatment of a number of inflammatory diseases including RA, partial and non-responder patients constitute residual unmet clinical need. The aim of this article is to briefly review the biology of, and experimental approaches to IL-18 neutralisation, together with speculation as to the relative merits of IL-18 as an alternative to existing targets.
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Metadata
Title
Interleukin-18: a therapeutic target in rheumatoid arthritis?
Authors
Iain B McInnes
Foo Y Liew
J Alastair Gracie
Publication date
01-11-2004
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2004
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1497

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