Published in:
01-07-2008 | Letter to the Editor
Interleukin-10 (-819 C/T) and TNF-A (-308 G/A) as Risk Factors for H. pylori-Associated Gastric MALT-Lymphoma
Authors:
Stephan Hellmig, Tobias Bartscht, Wolfgang Fischbach, Ulrich Robert Fölsch, Stefan Schreiber
Published in:
Digestive Diseases and Sciences
|
Issue 7/2008
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Excerpt
With great interest we read the article by Achyut et al. about the influence of genetic variants in the promoter region of the Interleukin-10 (IL-10) and tumor necrosis factor alpha (TNF-A) gene on gastritis and lymphoid follicle development in patients with
H. pylori infection [
1]. The authors genotyped 130 patients with non-ulcer dyspepsia (NUD) and 200 healthy age-matched controls for IL-10 (-819) and TNF-A (-308). They found that carriers of the TNF-A (-308) A allele had a more than twofold increased risk of lymphoid follicle formation. It is generally accepted that the presence of lymphoid follicles and mucosa associated lymphatic tissue (MALT) is solely a sequelae of
H. pylori infection [
2,
3]. Pro-inflammatory genetic polymorphisms may influence the histological degree of mucosal inflammation [
4] which may vary according to the localization of the biopsy. To identify a robust association of germline polymorphisms with the outcome of
H. pylori infection, unambiguous phenotypes such as ulcer disease, gastric carcinoma, or primary gastric B-cell lymphoma are needed. …
