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Journal of Experimental & Clinical Cancer Research
Published in: Journal of Experimental & Clinical Cancer Research 1/2021

01-12-2021 | Interferon | Review

Cytosolic sensor STING in mucosal immunity: a master regulator of gut inflammation and carcinogenesis

Authors: Qiongyuan Hu, Quan Zhou, Xuefeng Xia, Lihua Shao, Meng Wang, Xiaofeng Lu, Song Liu, Wenxian Guan

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2021

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Abstract

The stimulator of interferon genes (STING) connects microbial cytosolic sensing with host cell effector functions. STING signaling plays a central role in cyclic dinucleotides (CDNs) and DNA sensing to induce secretion of interferons and pro-inflammatory mediators. Although activated STING signaling favors antimicrobial progress and facilitates mucosal would healing, its role in mucosal immunity and gut homeostasis is paradoxical, ranging from positive and negative effects within the gut. In our review, we summarize recent advance of STING signaling in gut homeostasis and inflammation, especially focusing on its molecular basis in mucosal immune response. Deep understanding of the regulatory mechanisms of intestinal STING pathway could promote clinical manipulation of this fundamental signaling as a promising immunomodulatory therapy.
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Metadata
Title
Cytosolic sensor STING in mucosal immunity: a master regulator of gut inflammation and carcinogenesis
Authors
Qiongyuan Hu
Quan Zhou
Xuefeng Xia
Lihua Shao
Meng Wang
Xiaofeng Lu
Song Liu
Wenxian Guan
Publication date
01-12-2021
Publisher
BioMed Central
Keyword
Interferon
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2021
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/s13046-021-01850-9

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