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International Ophthalmology

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01-12-2019 | Intense Pulsed Light | Original Paper

Long-term changes in retinal layers in patients undergoing intravitreal ranibizumab for neovascular age-related macular degeneration

Retinal layers after anti-VEGF therapy

Authors: Ümit Übeyt Inan, Zeki Baysal, Sibel Inan

Published in: International Ophthalmology | Issue 12/2019

Abstract

Purpose

To analyze long-term changes in individual retinal layers (RLs) after intravitreal injections of ranibizumab (IVRs) in patients with neovascular age-related macular degeneration (n-AMD).

Methods

The patients were treated with 0.5-mg IVRs based on an as-needed protocol after the first three monthly doses over a 12-month follow-up period. Patients underwent optical coherence tomography and best-corrected visual acuity (BCVA) evaluation at each visit. The ETDRS grid with central subfield (R1) (r 0.5 mm) and the inner ring (R2) (r 0.5–1.5 mm) was used for calculation of the mean thickness of each RL. Changes in the thickness of segmented RLs within the R1 and R2 of ETDRS circles at months-3, -6, and -12 were compared to baseline.

Results

The mean age was 72 ± 7.4 years. The mean number of injections was 9.08 (range 6–11). Mean BCVA improved from 49.7 ± 22.1 to 60.1 ± 19.8 letters. Central macular thickness decreased from 390.25 ± 149.6 to 312.74 ± 118.4 μm. Thicknesses of GCL (from 23.93 ± 13.73 to 19.50 ± 9.50 μm in R1; p 0.001, and from 44.5 ± 12.6 to 39.6 ± 10.6 μm in R2; p 0.005), IPL (from 28.90 ± 14.36 to 22.35 ± 6.23 μm in R1; p 0.001, and from 39.34 ± 8.53 to 35.58 ± 7.93 μm in R2; p 0.004), and total inner RL (ILM to ELM) (from 222.93 ± 93.09 to 180 ± 53 μm in R1; p 0.001, and from 255.06 ± 42.74 to 240.25 ± 40.37 μm in R2; p 0.003) in the central and parafoveal rings decreased statistically at month-12. Decrease in INL was limited to month-6 (from 34.80 ± 15.33 to 27.60 ± 12.59 μm in R1; p 0.001), while decreases in total outer RLs (ELM to RPE) (from 128.32 ± 26.92 to 115.54 ± 43.98 μm in R1; p 0.001, and 103.81 ± 16.73 to 96.38 ± 16.22 μm in R2; p 0.014) and RPE (from 39.12 ± 22.33 to 29.70 ± 22.05 μm in R1; p 0.001, and from 31.27 ± 13.11 to 24.40 ± 9.99 μm in R2; p 0.001) were limited to month-3.

Conclusions

Significant changes were observed in the thickness of the inner RLs after 1-year treatment with IVRs for n-AMD. A significant decrease in RPE thickness confined to the first months disappeared at month-12.

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Title: Long-term changes in retinal layers in patients undergoing intravitreal ranibizumab for neovascular age-related macular degeneration
Retinal layers after anti-VEGF therapy
Authors: Ümit Übeyt Inan
Zeki Baysal
Sibel Inan
Publication date: 01-12-2019
Publisher: Springer Netherlands
Keywords: Intense Pulsed Light
Edema
Macular Degeneration
Ranibizumab
Published in: International Ophthalmology / Issue 12/2019
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-019-01116-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Long-term changes in retinal layers in patients undergoing intravitreal ranibizumab for neovascular age-related macular degeneration

Retinal layers after anti-VEGF therapy

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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