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Archives of Orthopaedic and Trauma Surgery
Published in: Archives of Orthopaedic and Trauma Surgery 7/2010

01-07-2010 | Orthopaedic Surgery

Integrated FDG-PET-CT: its role in the assessment of bone and soft tissue tumors

Authors: Mark Bischoff, Gisela Bischoff, Andreas Buck, Alexandra von Baer, Sandra Pauls, Florian Scheffold, Markus Schultheiss, Florian Gebhard, Sven N. Reske

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 7/2010

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Abstract

Purpose

The purpose of this study was to evaluate prospectively, whether integrated 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography-computed tomography (FDG-PET-CT) is more accurate for determination musculoskeletal tumors compared with separate interpretation of CT and FDG-PET, because most of the current clinical data come from patients studied with PET.

Methods

Eighty patients with newly diagnosed musculoskeletal tumors underwent FDG-PET-CT. CT, FDG-PET, and FDG-PET-CT were interpreted separately to determine the performance of each imaging modality.

Results

Assuming that equivocal lesions are benign, performance of diagnostic tests was as follows: sensitivity, specificity and accuracy for CT alone was 81, 84, 83%, for PET 71, 82, 76, and for PET-CT 80, 83 and 86%. Assuming that equivocal lesions are malignant, sensitivity, specificity, and accuracy for CT was 61, 100, 70%, for PET 69, 100, 79, and for PET-CT 69, 100 and 79%.

Conclusions

Combined FDG-PET-CT reliably differentiates soft tissue and bone tumors from benign lesions. The value of the information provided by FDG-PET-CT for planning surgical procedures must be evaluated in further studies.
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Metadata
Title
Integrated FDG-PET-CT: its role in the assessment of bone and soft tissue tumors
Authors
Mark Bischoff
Gisela Bischoff
Andreas Buck
Alexandra von Baer
Sandra Pauls
Florian Scheffold
Markus Schultheiss
Florian Gebhard
Sven N. Reske
Publication date
01-07-2010
Publisher
Springer-Verlag
Published in
Archives of Orthopaedic and Trauma Surgery / Issue 7/2010
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI
https://doi.org/10.1007/s00402-009-0937-2

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