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Endocrine
Published in: Endocrine 2/2022

14-06-2022 | Insulins | Original Article

The relationship between estimated glucose disposal rate and bone turnover markers in type 2 diabetes mellitus

Authors: Zelin Li, Cuijuan Qi, Xiaoyu Pan, Yujiao Jia, Xuetong Zhao, Chenqian Deng, Shuchun Chen

Published in: Endocrine | Issue 2/2022

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Abstract

Purpose

To investigate the relationship between estimated glucose disposal rate (eGDR) and bone turnover markers in patients with type 2 diabetes mellitus (T2DM).

Materials and methods

This is a cross-sectional study, which recruited 549 patients with T2DM. The eGDRs of patients were calculated based on the presence of hypertension, glycated hemoglobin, and body mass index. All patients were divided into high-eGDR group and low-eGDR group using the median of eGDR as the boundary. The patients were further divided into two subgroups: males and postmenopausal females.

Results

The lower the eGDR, the more severe was insulin resistance. The levels of osteocalcin (OC), type I collagen carboxyl-terminal peptide (β-CTX), and type I procollagen amino-terminal peptide (PINP) were significantly lower in the low-eGDR group than those in the high-eGDR group. The eGDR was positively correlated with OC, β-CTX, and PINP in all patients, and in the male subgroups. In the postmenopausal female subgroup, there was no correlation between eGDR and OC, β-CTX, or PINP. In addition, this positive correlation remained after adjusting for other factors in multilinear regression analysis.

Conclusion

Our study was the first to demonstrate that eGDR is positively correlated with bone turnover markers in patients with T2DM. This correlation was observed among the male patients with T2DM but not among postmenopausal female patients with T2DM.
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Metadata
Title
The relationship between estimated glucose disposal rate and bone turnover markers in type 2 diabetes mellitus
Authors
Zelin Li
Cuijuan Qi
Xiaoyu Pan
Yujiao Jia
Xuetong Zhao
Chenqian Deng
Shuchun Chen
Publication date
14-06-2022
Publisher
Springer US
Published in
Endocrine / Issue 2/2022
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-022-03090-z

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