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Metabolic Brain Disease
Published in: Metabolic Brain Disease 5/2017

01-10-2017 | Review Article

Insulin resistance in ischemic stroke

Authors: Xiao-Ling Deng, Zhou Liu, Chuanling Wang, Yanfeng Li, Zhiyou Cai

Published in: Metabolic Brain Disease | Issue 5/2017

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Abstract

Insulin resistance often refers to a pathological condition in which cells fail to respond to the normal actions of insulin. Increasing literature has noted a critical role of insulin resistance in the pathogenesis of ischemic stroke. Insulin resistance plays an important role in the pathogenesis of ischemic stroke via enhancing advanced changes of atherosclerosis. A variety of literature indicates that insulin resistance enhances platelet adhesion, activation and aggregation which are conducive to the occurrence of ischemic stroke. Insulin resistance also induces hemodynamic disturbances and contributes to the onset of ischemic stroke. In addition, insulin resistance may augment the role of the modifiable risk factors in ischemic stroke and induce the occurrence of ischemic stroke. Preclinical and clinical studies have supported that improving insulin resistance may be an effective measure to prevent or delay ischemic stroke.
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Metadata
Title
Insulin resistance in ischemic stroke
Authors
Xiao-Ling Deng
Zhou Liu
Chuanling Wang
Yanfeng Li
Zhiyou Cai
Publication date
01-10-2017
Publisher
Springer US
Published in
Metabolic Brain Disease / Issue 5/2017
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI
https://doi.org/10.1007/s11011-017-0050-0

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