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01-03-2022 | Insomnia | Sleep Breathing Physiology and Disorders • Original Article

Investigation of the relationships between sleep behaviors and risk of healthspan termination: a prospective cohort study based on 323,373 UK-Biobank participants

Authors: Muhammed Lamin Sambou, Xiaoyu Zhao, Tongtong Hong, Muhammad Naveed, Alima Sambou, Fadoua El Hafa, TIl B. Basnet, Juncheng Dai

Published in: Sleep and Breathing | Issue 1/2022

Abstract

Objectives

To examine the associations between four sleep behaviors and the risk of healthspan termination.

Methods

This study included 323,373 participants, free of terminated healthspan at baseline, from the UK-Biobank (UKB). We applied multivariable-adjusted Cox regression models to estimate the risk of terminated healthspan based on four sleep behaviors (insomnia/sleeplessness, napping, daytime sleepiness, and difficulty getting up from bed), which were self-reported and measured on Likert scales from “usually” to “never/rarely” experiences. In this study, healthspan was defined based on eight events that are strongly associated with longevity (congestive heart failure, myocardial infarction, chronic obstructive pulmonary disease, stroke, dementia, diabetes, cancer, and death).

Results

Participants who reported the following unhealthy sleep behaviors had a significantly higher risk of terminated healthspan: “usually experience sleeplessness/insomnia” (HR = 1.05, 95% CI: 1.03–1.07; P < 0.001); “usually nap” (HR = 1.22, 95% CI: 1.18–1.26; P < 0.01); “excessive daytime sleepiness” (HR = 1.25, 95% CI: 1.19–1.32; P < 0.001); and “difficult getting up from bed” (HR = 1.08, 95% CI: 1.05–1.10; P < 0.001). The corresponding population attributable risk percentage (PAR%) indicated that about 7% of healthspan termination in this cohort would have been eliminated if all participants had healthy sleep behaviors.

Conclusion

Participants who reported “usually experience sleeplessness/insomnia,” “usually nap,” “excessive daytime sleepiness,” and “difficult getting up from bed” had increased risk of shortened healthspan. Therefore, adherence to healthy sleep behavior is significant for the extension of healthspan.

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Title: Investigation of the relationships between sleep behaviors and risk of healthspan termination: a prospective cohort study based on 323,373 UK-Biobank participants
Authors: Muhammed Lamin Sambou
Xiaoyu Zhao
Tongtong Hong
Muhammad Naveed
Alima Sambou
Fadoua El Hafa
TIl B. Basnet
Juncheng Dai
Publication date: 01-03-2022
Publisher: Springer International Publishing
Keyword: Insomnia
Published in: Sleep and Breathing / Issue 1/2022
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02394-0

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Abstract

Objectives

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