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Journal of Bone and Mineral Metabolism
Published in: Journal of Bone and Mineral Metabolism 2/2015

01-03-2015 | Original Article

Inhibitory effect of bisphosphonate on osteoclast function contributes to improved skeletal pain in ovariectomized mice

Authors: Yasuhisa Abe, Kousuke Iba, Koichi Sasaki, Hironori Chiba, Kumiko Kanaya, Tomoyuki Kawamata, Kimimitsu Oda, Norio Amizuka, Muneteru Sasaki, Toshihiko Yamashita

Published in: Journal of Bone and Mineral Metabolism | Issue 2/2015

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Abstract

The aim of this study was to evaluate skeletal pain associated with osteoporosis and to examine the inhibitory effect of bisphosphonate (BP) on pain in an ovariectomized (OVX) mouse model. We evaluated skeletal pain in OVX mice through an examination of pain-like behavior as well as immunohistochemical findings. In addition, we assessed the effects of alendronate (ALN), a potent osteoclast inhibitor, on those parameters. The OVX mice showed a decrease in the pain threshold value, and an increase in the number of c-Fos immunoreactive neurons in laminae I–II of the dorsal horn of the spinal cord. Alendronate caused an increase in the pain threshold value and inhibited c-Fos expression. The serum level of tartrate-resistant acid phosphatase 5b, a marker of osteoclast activity, was significantly negatively correlated with the pain threshold value. Furthermore, we found that an antagonist of the transient receptor potential channel vanilloid subfamily member 1, which is an acid-sensing nociceptor, improved pain-like behavior in OVX mice. These results indicated that the inhibitory effect of BP on osteoclast function might contribute to an improvement in skeletal pain in osteoporosis patients.
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Metadata
Title
Inhibitory effect of bisphosphonate on osteoclast function contributes to improved skeletal pain in ovariectomized mice
Authors
Yasuhisa Abe
Kousuke Iba
Koichi Sasaki
Hironori Chiba
Kumiko Kanaya
Tomoyuki Kawamata
Kimimitsu Oda
Norio Amizuka
Muneteru Sasaki
Toshihiko Yamashita
Publication date
01-03-2015
Publisher
Springer Japan
Published in
Journal of Bone and Mineral Metabolism / Issue 2/2015
Print ISSN: 0914-8779
Electronic ISSN: 1435-5604
DOI
https://doi.org/10.1007/s00774-014-0574-x

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