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Archives of Virology
Published in: Archives of Virology 3/2020

01-03-2020 | Influenza Virus | Original Article

Transition in genetic constellations of H3N8 and H4N6 low-pathogenic avian influenza viruses isolated from an overwintering site in Japan throughout different winter seasons

Authors: Ahmed Magdy Khalil, Natsuko Nishi, Isshu Kojima, Wataru Fukunaga, Masakazu Kuwahara, Tatsunori Masatani, Tsutomu Matsui, Makoto Ozawa

Published in: Archives of Virology | Issue 3/2020

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Abstract

The Izumi plain in Kagoshima Prefecture, Japan, is an overwintering site for migratory ducks and endangered cranes. We have surveyed avian influenza viruses (AIVs) in this area since 2012 and isolated low-pathogenic AIVs (LPAIVs) of various subtypes every winter season. H3N8 LPAIVs were isolated during the 2012/13 and 2016/17 seasons, and H4N6 LPAIVs were isolated during the 2012/13 and 2013/14 seasons. In the 2017/18 season, one H3N8 and two H4N6 LPAIV strains were isolated from environmental water samples. Genetic and phylogenetic analysis for each gene segment from these H3N8 and H4N6 LPAIVs suggested that our isolates were genetic reassortants generated by intermixing between AIVs circulating not only in Eurasia but also in Africa and/or North America. Comparison of the genetic constellations of our three isolates with their counterparts isolated during previous seasons from the Izumi plain revealed a drastic transition in the genetic constellations of both subtypes. These findings emphasize the importance of continuous surveillance of AIVs on the Izumi plain.
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Metadata
Title
Transition in genetic constellations of H3N8 and H4N6 low-pathogenic avian influenza viruses isolated from an overwintering site in Japan throughout different winter seasons
Authors
Ahmed Magdy Khalil
Natsuko Nishi
Isshu Kojima
Wataru Fukunaga
Masakazu Kuwahara
Tatsunori Masatani
Tsutomu Matsui
Makoto Ozawa
Publication date
01-03-2020
Publisher
Springer Vienna
Keyword
Influenza Virus
Published in
Archives of Virology / Issue 3/2020
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-019-04519-z

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