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Published in: Journal of the Association for Research in Otolaryngology 2/2005

01-06-2005 | Research Article

Influence of Supporting Cells on Neuronal Degeneration After Hair Cell Loss

Authors: Mitsuru Sugawara, Gabriel Corfas, M. Charles Liberman

Published in: Journal of the Association for Research in Otolaryngology | Issue 2/2005

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Abstract

In sensorineural hearing loss, hair cell loss is often followed by loss of cochlear nerve fibers, which can continue for years after the insult. The degree and time course of neuronal loss varies, but the reasons for this variation are unclear. The present study addresses this issue with a quantitative analysis of hair cell, supporting cell, and neuronal survival in animals with long-term survival of up to 5.5 years from two types of drug-induced hair cell loss: aminoglycoside antibiotics and platinum-containing chemotherapeutics. To complement the analysis of the effects of organ of Corti damage on neuronal survival, cases of primary neuronal degeneration, via auditory nerve section, are also assessed. Analysis shows that (1) long-term neuronal survival is enhanced when supporting cells in the inner hair cell (IHC) area remain intact; (2) after hair cell loss, the time course of neuronal loss is slower in the apex than in the base; (3) primary loss of cochlear nerve fibers does not lead to secondary degeneration of sensory cells or supporting cells in the organ of Corti; and (4) after auditory nerve section, there can be a massive reinnervation of the IHC region, especially in the apex. Results are consistent with the idea that supporting cells participate in the regulation of neuronal survival and neuronal sprouting in the organ of Corti.
Footnotes
1
Maximal neuronal densities in the treated ears appear systematically higher than normal (by 20–40%) in regions where most IHCs remain. Reasons for this are unclear, as control animals were of similar age and the same sex as the treated animals. The possibility that the carboplatin treatment led to neuronal sprouting has to be considered, but more data are needed.
 
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Metadata
Title
Influence of Supporting Cells on Neuronal Degeneration After Hair Cell Loss
Authors
Mitsuru Sugawara
Gabriel Corfas
M. Charles Liberman
Publication date
01-06-2005
Publisher
Springer-Verlag
Published in
Journal of the Association for Research in Otolaryngology / Issue 2/2005
Print ISSN: 1525-3961
Electronic ISSN: 1438-7573
DOI
https://doi.org/10.1007/s10162-004-5050-1

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