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European Radiology

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01-04-2015 | Breast

Influence of scan duration on the estimation of pharmacokinetic parameters for breast lesions: a study based on CAIPIRINHA-Dixon-TWIST-VIBE technique

Authors: Wen Hao, Bin Zhao, Guangbin Wang, Cuiyan Wang, Hui Liu

Published in: European Radiology | Issue 4/2015

Abstract

Objectives

To evaluate the influence of scan duration on pharmacokinetic parameters and their performance in differentiating benign from malignant breast lesions.

Methods

Dynamic breast imaging was performed on a 3.0-T MR system using a prototype CAIPIRINHA-Dixon-TWISTVIBE (CDT-VIBE) sequence with a temporal resolution of 11.9 s. Enrolled in the study were 53 women with 55 lesions (26 benign and 29 malignant). Pharmacokinetic parameters (Ktrans, ve , kep and iAUC) were calculated for various scan durations from 1 to 7 min after injection of contrast medium using the Tofts model.

Results

Ktrans, kep and ve calculated from the 1-min dataset were significantly different from those calculated from the other datasets. In benign lesions, Ktrans, kep and ve were significantly different only between 1 min and 2 min (corrected P > 0.05), but in malignant lesions there were significant differences for any of the comparisons up to 6 min vs. 7 min (corrected P > 0.05). There were no significant differences in AUCs for any of the parameters (P > 0.05).

Conclusions

In breast dynamic contrast-enhanced MRI the scan duration has a significant impact on pharmacokinetic parameters, but the diagnostic ability may not be significantly affected. A scan duration of 5 min after injection of contrast medium may be sufficient for calculation of Tofts model pharmacokinetic parameters.

Key Points

• Scan duration of DCE-MRI breast imaging has a significant impact on pharmacokinetic parameters

• A scan duration of less than 2 min results in spurious parameter estimates

• The initial 2 min are important for both benign and malignant lesions

• In malignant lesions the impact extends to 4 – 6 min

• The differentiation ability of parameters may not be affected by scan duration

Moon M, Cornfeld D, Weinreb J (2009) Dynamic contrast-enhanced breast MR imaging. Magn Reson Imaging Clin N Am 17:351–362CrossRefPubMed

Barrett T, Brechbiel M, Bernardo M, Choyke PL (2007) MRI of tumor angiogenesis. J Magn Reson Imaging 26:235–249CrossRefPubMed

Huang W, Tudorica LA, Li X et al (2011) Discrimination of benign and malignant breast lesions by using shutter-speed dynamic contrast-enhanced MR imaging. Radiology 261:394–403CrossRefPubMedCentralPubMed

Schabel MC, Morrell GR, Oh KY, Walczak CA, Barlow RB, Neumayer LA (2010) Pharmacokinetic mapping for lesion classification in dynamic breast MRI. J Magn Reson Imaging 31:1371–1378CrossRefPubMed

Eyal E, Badikhi D, Furman-Haran E, Kelcz F, Kirshenbaum KJ, Degani H (2009) Principal component analysis of breast DCE-MRI adjusted with a model-based method. J Magn Reson Imaging 30:989–998CrossRefPubMedCentralPubMed

Vincensini D, Dedieu V, Eliat PA et al (2007) Magnetic resonance imaging measurements of vascular permeability and extracellular volume fraction of breast tumors by dynamic Gd-DTPA-enhanced relaxometry. Magn Reson Imaging 25:293–302CrossRefPubMed

Ah-See MW, Makris A, Taylor NJ et al (2008) Early changes in functional dynamic magnetic resonance imaging predict for pathologic response to neoadjuvant chemotherapy in primary breast cancer. Clin Cancer Res 14:6580–6589CrossRefPubMed

Yankeelov TE, Lepage M, Chakravarthy A et al (2007) Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results. Magn Reson Imaging 25:1–13CrossRefPubMedCentralPubMed

Yu Y, Jiang Q, Miao Y et al (2010) Quantitative analysis of clinical dynamic contrast-enhanced MR imaging for evaluating treatment response in human breast cancer. Radiology 257:47–55CrossRefPubMedCentralPubMed

10.

Michaely HJ, Morelli JN, Budjan J et al (2013) CAIPIRINHA-Dixon-TWIST (CDT)-volume-interpolated breath-hold examination (VIBE): a new technique for fast time-resolved dynamic 3-dimensional imaging of the abdomen with high spatial resolution. Invest Radiol 48:590–597CrossRefPubMed

11.

American College of Radiology (2014) ACR practice parameter for the performance of contrast-enhanced magnetic resonance imaging (MRI) of the breast. American College of Radiology, Reston, VA. Available via http://www.acr.org/~/media/ACR/Documents/PGTS/guidelines/MRI_Breast.pdf. Accessed 25 Sep 2014

12.

Song T, Laine AF, Chen Q et al (2009) Optimal k-space sampling for dynamic contrast-enhanced MRI with an application to MR renography. Magn Reson Med 61:1242–1248CrossRefPubMedCentralPubMed

13.

Mann RM, Mus RD, van Zelst J, Geppert C, Karssemeijer N, Platel B (2014) A novel approach to contrast-enhanced breast magnetic resonance imaging for screening: high-resolution ultrafast dynamic imaging. Invest Radiol 49:579–585CrossRefPubMed

14.

Tudorica LA, Oh KY, Roy N et al (2012) A feasible high spatiotemporal resolution breast DCE-MRI protocol for clinical settings. Magn Reson Imaging 30:1257–1267CrossRefPubMedCentralPubMed

15.

Herrmann KH, Baltzer PA, Dietzel M et al (2011) Resolving arterial phase and temporal enhancement characteristics in DCE MRM at high spatial resolution with TWIST acquisition. J Magn Reson Imaging 34:973–982CrossRefPubMed

16.

Aerts HJ, Jaspers K, Backes WH (2011) The precision of pharmacokinetic parameters in dynamic contrast-enhanced magnetic resonance imaging: the effect of sampling frequency and duration. Phys Med Biol 56:5665–5678CrossRefPubMed

17.

Jaspers K, Aerts HJ, Leiner T et al (2009) Reliability of pharmacokinetic parameters: small vs. medium-sized contrast agents. Magn Reson Med 62:779–787CrossRefPubMed

18.

Jena A, Mehta SB, Taneja S (2013) Optimizing MRI scan time in the computation of pharmacokinetic parameters (K(trans) ) in breast cancer diagnosis. J Magn Reson Imaging 38:573–579CrossRefPubMed

19.

Ellinger R, Kremser C, Schocke MF et al (2000) The impact of peak saturation of the arterial input function on quantitative evaluation of dynamic susceptibility contrast-enhanced MR studies. J Comput Assist Tomogr 24:942–948CrossRefPubMed

20.

Pedevilla M, Stollberger R, Wach P, Ebner F (1998) Influence of capillary blood flow and first pass effects on determination of tissue permeability. Proceedings of the Sixth Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Sydney. p 1651

21.

Parker GJ, Buckley DL (2005) Tracer kinetic modeling for T1-weighted DCE-MRI. In: Jackson A, Buckley DL, Parker GJ (eds) Dynamic contrast-enhanced magnetic resonance imaging in oncology. Springer, Berlin, pp 81–92CrossRef

22.

Tofts PS (1997) Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. J Magn Reson Imaging 7:91–101CrossRefPubMed

23.

Kuhl CK, Mielcareck P, Klaschik S et al (1999) Dynamic breast MR imaging: are signal intensity time course data useful for differential diagnosis of enhancing lesions? Radiology 211:101–110CrossRefPubMed

24.

Veltman J, Stoutjesdijk M, Mann R et al (2008) Contrast-enhanced magnetic resonance imaging of the breast: the value of pharmacokinetic parameters derived from fast dynamic imaging during initial enhancement in classifying lesions. Eur Radiol 18:1123–1133CrossRefPubMedCentralPubMed

25.

El Khouli RH, Macura KJ, Kamel IR, Jacobs MA, Bluemke DA (2011) 3-T dynamic contrast-enhanced MRI of the breast: pharmacokinetic parameters versus conventional kinetic curve analysis. AJR Am J Roentgenol 197:1498–1505CrossRefPubMedCentralPubMed

26.

Stoutjesdijk MJ, Zijp M, Boetes C, Karssemeijer N, Barentsz JO, Huisman H (2012) Computer aided analysis of breast MRI enhancement kinetics using mean shift clustering and multifeature iterative region of interest selection. J Magn Reson Imaging 36:1104–1112CrossRefPubMed

27.

Garcia EM, Storm ES, Atkinson L, Kenny E, Mitchell LS (2013) Current breast imaging modalities, advances, and impact on breast care. Obstet Gynecol Clin N Am 40:429–457CrossRef

28.

Le Y, Kipfer H, Majidi S et al (2013) Application of time-resolved angiography with stochastic trajectories (TWIST)-Dixon in dynamic contrast-enhanced (DCE) breast MRI. Magn Reson Imaging 38:1033–1042CrossRef

29.

Le Y, Kroeker R, Kipfer HD, Lin C (2012) Development and evaluation of TWIST Dixon for dynamic contrast-enhanced (DCE) MRI with improved acquisition efficiency and fat suppression. Magn Reson Imaging 36:483–491CrossRef

30.

Krishnan S, Chenevert TL (2004) Spatio-temporal bandwidth-based acquisition for dynamic contrast-enhanced magnetic resonance imaging. J Magn Reson Imaging 20:129–137CrossRefPubMed

31.

Oesterle C, Strohschein R, Kohler M, Schnell M, Hennig J (2000) Benefits and pitfalls of keyhole imaging, especially in first-pass perfusion studies. J Magn Reson Imaging 11:312–323CrossRefPubMed

32.

Deshmane A, Gulani V, Griswold MA, Seiberlich N (2012) Parallel MR imaging. J Magn Reson Imaging 36:55–72CrossRefPubMed

33.

Gibbs P, Liney GP, Lowry M, Kneeshaw PJ, Turnbull LW (2004) Differentiation of benign and malignant sub-1 cm breast lesions using dynamic contrast enhanced MRI. Breast 13:115–121CrossRefPubMed

Title: Influence of scan duration on the estimation of pharmacokinetic parameters for breast lesions: a study based on CAIPIRINHA-Dixon-TWIST-VIBE technique
Authors: Wen Hao
Bin Zhao
Guangbin Wang
Cuiyan Wang
Hui Liu
Publication date: 01-04-2015
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 4/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3451-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Influence of scan duration on the estimation of pharmacokinetic parameters for breast lesions: a study based on CAIPIRINHA-Dixon-TWIST-VIBE technique

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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