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01-08-2007

Influence of Rifampin on Capsule Formation Around Silicone Implants in a Rat Model

Authors: Ramazan Erkin Unlu, M.D., Asu Deniz Yilmaz, M.D., Hakan Orbay, M.D., Belgin Can, M.D., Ibrahim Tekdemir, Ph.D., Omer Sensoz, M.D.

Published in: Aesthetic Plastic Surgery | Issue 4/2007

Abstract

This study investigated the effect of rifampin on the thickness of capsules around silicone implants by bactericidal activity against Stapylococcus epidermidis. Silicone blocks (1 × 1 cm) were placed into pockets created for each of the 40 rats included in the study. In group 1, the operation was performed under aseptic conditions. In group 2, standard S. epidermidis was inoculated into the pocket, whereas rifampin and S. epidermidis were applied in group 3. In group 4, only rifampin was applied topically on implants. After 12 weeks, the peri-implant capsules were removed and examined under a photomicroscope and a scanning electron microscope. The mean thickness of the capsules was 63.307 μm in group 1, 111.538 μm in group 2, 43.076 μm in group 3, and 30.384 μm in group 4. The differences between groups 2 and 3 and groups 2 and 4 were found to be statistically significant (p < 0.001). Rifampin appears to be an agent for preventing peri-implant capsule formation.

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Title: Influence of Rifampin on Capsule Formation Around Silicone Implants in a Rat Model
Authors: Ramazan Erkin Unlu, M.D.
Asu Deniz Yilmaz, M.D.
Hakan Orbay, M.D.
Belgin Can, M.D.
Ibrahim Tekdemir, Ph.D.
Omer Sensoz, M.D.
Publication date: 01-08-2007
Publisher: Springer-Verlag
Published in: Aesthetic Plastic Surgery / Issue 4/2007
Print ISSN: 0364-216X
Electronic ISSN: 1432-5241
DOI: https://doi.org/10.1007/s00266-006-0248-8

At a glance: The STEP trials

Springer Medicine

Influence of Rifampin on Capsule Formation Around Silicone Implants in a Rat Model

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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