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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 1/2013

01-07-2013 | Original Article

Influence of androgen deprivation therapy on choline PET/CT in recurrent prostate cancer

Authors: Rutger J. Dost, Andor W. J. M. Glaudemans, Anthonius J. Breeuwsma, Igle J. de Jong

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Special Issue 1/2013

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Abstract

Purpose

Recurrent prostate cancer is usually treated by combining radiotherapy and androgen deprivation therapy. To stage the cancer, choline positron emission tomography (PET)/CT can be performed. It is generally thought that androgen deprivation therapy does not influence choline PET/CT. In this article we focus on the molecular backgrounds of choline and androgens, and the results of preclinical and clinical studies performed using PET/CT.

Methods

Using PubMed, we looked for the relevant articles about androgen deprivation therapy and choline PET/CT.

Results

During ADT, a tendency of decreased uptake of choline in prostate cancer was observed, in particular in hormone-naïve patients.

Conclusion

We conclude that in order to prevent false-negative choline PET/CT scans androgen deprivation should be withheld prior to scanning, especially in hormone-naïve patients.
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Metadata
Title
Influence of androgen deprivation therapy on choline PET/CT in recurrent prostate cancer
Authors
Rutger J. Dost
Andor W. J. M. Glaudemans
Anthonius J. Breeuwsma
Igle J. de Jong
Publication date
01-07-2013
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue Special Issue 1/2013
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-013-2398-7

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