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Published in: Rheumatology International 1/2011

01-01-2011 | Case Report

Infliximab therapy in pediatric Takayasu’s arteritis: report of two cases

Authors: Paola Sabrina Buonuomo, Claudia Bracaglia, Andrea Campana, Antonella Insalaco, Manuela Pardeo, Elisabetta Cortis, Alberto G. Ugazio

Published in: Rheumatology International | Issue 1/2011

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Abstract

Takayasu arteritis (TA) is a chronic vasculitis of unknown etiology. Experience with anti-tumor necrosis factor alpha (anti-TNF) agents in difficult-to-treat patients with TA is limited and refers to adult patients. Here, we present two cases of pediatric TA treated with infliximab, in which clinical remission was observed. Anti-TNF treatment represents a useful therapy in pediatric Takayasu arteritis too, especially to avoid the risk of long-term corticosteroids toxicity.
Literature
1.
go back to reference Arend WP, Michel BA, Bloch DA, Hunder GG et al (1990) The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum 33(8):1129–1134CrossRefPubMed Arend WP, Michel BA, Bloch DA, Hunder GG et al (1990) The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum 33(8):1129–1134CrossRefPubMed
2.
go back to reference Sharma BK, Jain S, Sagar S (1997) Systemic manifestations of Takayasu arteritis: the expanding spectrum. Int J Cardiol 54(Suppl):S149–S154 Sharma BK, Jain S, Sagar S (1997) Systemic manifestations of Takayasu arteritis: the expanding spectrum. Int J Cardiol 54(Suppl):S149–S154
3.
go back to reference Seko Y, Minota S, Kawasaki A et al (1994) Perforin-secreting killer cell infiltration and expression of a 65-kDa heat-shock protein in aortic tissue of patients with Takayasu’s arteritis. J Clin Invest 93(2):750–758CrossRefPubMed Seko Y, Minota S, Kawasaki A et al (1994) Perforin-secreting killer cell infiltration and expression of a 65-kDa heat-shock protein in aortic tissue of patients with Takayasu’s arteritis. J Clin Invest 93(2):750–758CrossRefPubMed
4.
go back to reference Noris M, Daina E, Gamba S, Bonazzola S, Remuzzi G (1999) Interleukin-6 and RANTES in Takayasu arteritis: a guide for therapeutic decisions? Circulation 100(1):55–60PubMed Noris M, Daina E, Gamba S, Bonazzola S, Remuzzi G (1999) Interleukin-6 and RANTES in Takayasu arteritis: a guide for therapeutic decisions? Circulation 100(1):55–60PubMed
5.
go back to reference Hoffman GS, Leavitt RY, Kerr GS, Rottem M, Sneller MC, Fauci AS (1994) Treatment of glucocorticoid-resistant or relapsing Takayasu arteritis with methotrexate. Arthritis Rheum 37(4):578–582CrossRefPubMed Hoffman GS, Leavitt RY, Kerr GS, Rottem M, Sneller MC, Fauci AS (1994) Treatment of glucocorticoid-resistant or relapsing Takayasu arteritis with methotrexate. Arthritis Rheum 37(4):578–582CrossRefPubMed
6.
go back to reference Valsakumar AK, Valappil UC, Jorapur V, Garg N, Nityanand S, Sinha N (2003) Role of immunosuppressive therapy on clinical, immunological, and angiographic outcome in active Takayasu’s arteritis. J Rheumatol 30(8):1793–1798PubMed Valsakumar AK, Valappil UC, Jorapur V, Garg N, Nityanand S, Sinha N (2003) Role of immunosuppressive therapy on clinical, immunological, and angiographic outcome in active Takayasu’s arteritis. J Rheumatol 30(8):1793–1798PubMed
7.
go back to reference Hoffman GS, Merkel PA, Brasington RD, Lenschow DJ, Liang P (2004) Anti-tumor necrosis factor therapy in patients with difficult to treat Takayasu arteritis. Arthritis Rheum 50(7):2296–2304CrossRefPubMed Hoffman GS, Merkel PA, Brasington RD, Lenschow DJ, Liang P (2004) Anti-tumor necrosis factor therapy in patients with difficult to treat Takayasu arteritis. Arthritis Rheum 50(7):2296–2304CrossRefPubMed
8.
go back to reference Della Rossa A, Tavoni A, Merlini G et al (2005) Two Takayasu arteritis patients successfully treated with infliximab: a potential disease-modifying agent? Rheumatology (Oxf) 44:1074CrossRef Della Rossa A, Tavoni A, Merlini G et al (2005) Two Takayasu arteritis patients successfully treated with infliximab: a potential disease-modifying agent? Rheumatology (Oxf) 44:1074CrossRef
9.
go back to reference Karageorgaki ZT, Mavragani CP, Papathanasiou MA, Skopouli FN (2007) Infliximab in Takayasu arteritis: a safe alternative? Clin Rheumatol 26(6):984–987CrossRefPubMed Karageorgaki ZT, Mavragani CP, Papathanasiou MA, Skopouli FN (2007) Infliximab in Takayasu arteritis: a safe alternative? Clin Rheumatol 26(6):984–987CrossRefPubMed
10.
go back to reference Tanaka F, Kawakami A, Iwanaga N, Tamai M, Izumi Y et al (2006) Infliximab is effective for Takayasu arteritis refractory to glucocorticoid and methotrexate. Intern Med 45(5):313–316CrossRefPubMed Tanaka F, Kawakami A, Iwanaga N, Tamai M, Izumi Y et al (2006) Infliximab is effective for Takayasu arteritis refractory to glucocorticoid and methotrexate. Intern Med 45(5):313–316CrossRefPubMed
11.
go back to reference Hotchi M (1992) Pathological studies on Takayasu arteritis. Heart Vessels Suppl 37:11–27CrossRef Hotchi M (1992) Pathological studies on Takayasu arteritis. Heart Vessels Suppl 37:11–27CrossRef
13.
go back to reference Salvarani C, Cantini F, Boiardi L, Hunder GG (2003) Laboratory investigations useful in giant cell arteritis and Takayasu’s arteritis. Clin Exp Rheumatol 21(Suppl 32):S23–S28PubMed Salvarani C, Cantini F, Boiardi L, Hunder GG (2003) Laboratory investigations useful in giant cell arteritis and Takayasu’s arteritis. Clin Exp Rheumatol 21(Suppl 32):S23–S28PubMed
Metadata
Title
Infliximab therapy in pediatric Takayasu’s arteritis: report of two cases
Authors
Paola Sabrina Buonuomo
Claudia Bracaglia
Andrea Campana
Antonella Insalaco
Manuela Pardeo
Elisabetta Cortis
Alberto G. Ugazio
Publication date
01-01-2011
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 1/2011
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-009-1147-5

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