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Respiratory Research
Published in: Respiratory Research 1/2014

Open Access 01-12-2014 | Review

Inflammatory cytokines in pulmonary hypertension

Authors: Alexandra Groth, Bart Vrugt, Matthias Brock, Rudolf Speich, Silvia Ulrich, Lars C Huber

Published in: Respiratory Research | Issue 1/2014

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Abstract

Pulmonary hypertension is an “umbrella term” used for a spectrum of entities resulting in an elevation of the pulmonary arterial pressure. Clinical symptoms include dyspnea and fatigue which in the absence of adequate therapeutic intervention may lead to progressive right heart failure and death. The pathogenesis of pulmonary hypertension is characterized by three major processes including vasoconstriction, vascular remodeling and microthrombotic events. In addition accumulating evidence point to a cytokine driven inflammatory process as a major contributor to the development of pulmonary hypertension.
This review summarizes the latest clinical and experimental developments in inflammation associated with pulmonary hypertension with special focus on Interleukin-6, and its role in vascular remodeling in pulmonary hypertension.
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Metadata
Title
Inflammatory cytokines in pulmonary hypertension
Authors
Alexandra Groth
Bart Vrugt
Matthias Brock
Rudolf Speich
Silvia Ulrich
Lars C Huber
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2014
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/1465-9921-15-47

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