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Seminars in Immunopathology
Published in: Seminars in Immunopathology 3/2017

01-04-2017 | Review

Inflammatory bowel disease and cancer response due to anti-CTLA-4: is it in the flora?

Authors: Franck Carbonnel, Emilie Soularue, Clélia Coutzac, Nathalie Chaput, Christine Mateus, Patricia Lepage, Caroline Robert

Published in: Seminars in Immunopathology | Issue 3/2017

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Abstract

Checkpoint inhibitors blocking CTLA-4 (ipilimumab) and PD-1 (nivolumab, pembrolizumab) have transfigured our cancer treatment paradigm. However, these drugs can induce immune-related adverse events that share clinical and pathological characteristics with immune-mediated diseases. One of the most severe immune-related adverse event observed with anti-CTLA-4 is an enterocolitis that mirrors naturally occurring inflammatory bowel disease. This paper reviews the clinical, immunological, and microbiota data associated with the immune-related enterocolitis induced by the cancer immunotherapy blocking CTLA-4, ipilimumab. A parallel analysis of the mechanisms underlying inflammatory bowel diseases on the one hand, and anti-CTLA-4-induced colitis on the other hand, stresses the crucial role of the gut microbiota and of resident Treg in the genesis of both iatrogenic and spontaneous inflammatory bowel diseases.
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Metadata
Title
Inflammatory bowel disease and cancer response due to anti-CTLA-4: is it in the flora?
Authors
Franck Carbonnel
Emilie Soularue
Clélia Coutzac
Nathalie Chaput
Christine Mateus
Patricia Lepage
Caroline Robert
Publication date
01-04-2017
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 3/2017
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-016-0613-x

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