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Infection
Published in: Infection 3/2018

01-06-2018 | Case Report

Infections in patients on BCR-ABL tyrosine kinase inhibitor therapy: cases and review of the literature

Authors: Bettina M. Knoll, K. Seiter

Published in: Infection | Issue 3/2018

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Abstract

The introduction of BCR-ABL-tyrosine kinase inhibitors (TKI) for treatment of hematologic malignancies has made a significant impact on patient outcome. Contingent upon their targeted and off-target activity, therapy-associated infectious complications may occur. We present a case of cytomegalovirus pneumonitis and a case of adenovirus hemorrhagic cystitis in two patients with Philadelphia chromosome-positive acute lymphoblastic leukemia on BCR-ABL TKI treatment and review the literature to summarize the infectious complications based on clinical data. As life-threatening infections may occur, treating physicians should maintain a heightened awareness in patients treated with BCR-ABL TKIs. Based on the frequent reports of hepatitis B virus (HBV) reactivation under the treatment BCR-ABL TKIs, screening for and prophylactic therapy of chronic HBV infection should be considered. Similarly, patients would benefit from screening for and treatment of latent tuberculosis.
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Metadata
Title
Infections in patients on BCR-ABL tyrosine kinase inhibitor therapy: cases and review of the literature
Authors
Bettina M. Knoll
K. Seiter
Publication date
01-06-2018
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 3/2018
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-017-1105-1

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