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Critical Care
Published in: Critical Care 1/2011

Open Access 01-02-2011 | Poster presentation

Indoleamine-2,3-dioxygenase activity induces neutrophil apoptosis

Authors: K Van der Sluijs, R Singh, A Dijkhuis, M Snoek, R Lutter

Published in: Critical Care | Special Issue 1/2011

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Excerpt

Influenza-related mortality is often caused by secondary bacterial pneumonia. We have previously shown that the tryptophan-catabolizing enzyme indoleamine-2,3-dioxygenase (IDO) critically impairs host defense against secondary bacterial pneumonia [1]. Since inhibition of IDO resulted in increased neutrophil numbers during primary viral infection, we hypothesized that tryptophan degradation and/or the generation of downstream metabolites induces neutrophil apoptosis. In the present study we aimed to investigate the impact of IDO-mediated tryptophan metabolism on neutrophil apoptosis in vitro and in vivo. …
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Metadata
Title
Indoleamine-2,3-dioxygenase activity induces neutrophil apoptosis
Authors
K Van der Sluijs
R Singh
A Dijkhuis
M Snoek
R Lutter
Publication date
01-02-2011
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9628

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