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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 10/2006

01-10-2006 | Original Article

Increased Risk of Papillary Thyroid Cancer in Celiac Disease

Authors: Laura Kent, Russell McBride, Robert McConnell, Alfred I. Neugut, Govind Bhagat, Peter H. R. Green

Published in: Digestive Diseases and Sciences | Issue 10/2006

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Abstract

Patients with celiac disease have an increased rate of malignancies that are not limited to lymphomas. Thyroid carcinoma has not previously been associated with celiac disease. However, among a cohort of patients with celiac disease, we identified an increased risk of papillary carcinoma of the thyroid, standard morbidity ratio of 22.52 (95% confidence interval 14.90–34.04; P < .001), compared to United States national surveillance data. These patients were on a gluten-free diet. Only 1 had Hashimoto's thyroiditis, suggesting that mechanisms apart from autoimmune thyroiditis contribute to the increased risk of carcinoma of the thyroid in celiac disease.
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Metadata
Title
Increased Risk of Papillary Thyroid Cancer in Celiac Disease
Authors
Laura Kent
Russell McBride
Robert McConnell
Alfred I. Neugut
Govind Bhagat
Peter H. R. Green
Publication date
01-10-2006
Published in
Digestive Diseases and Sciences / Issue 10/2006
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-006-9240-z

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