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Clinical and Experimental Nephrology
Published in: Clinical and Experimental Nephrology 2/2017

01-04-2017 | Original Article

Increased non-HDL-C level linked with a rapid rate of renal function decline in HIV-infected patients

Authors: Masaki Hara, Naoki Yanagisawa, Akihito Ohta, Kumiko Momoki, Ken Tsuchiya, Kosaku Nitta, Minoru Ando

Published in: Clinical and Experimental Nephrology | Issue 2/2017

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Abstract

Background

The risk of developing CKD is increased in HIV-infected patients; however, the relationship between renal function decline and lipid abnormalities currently remains unclear in these patients.

Methods

A retrospective cohort study was conducted on 661 HIV-infected patients, whose estimated glomerular filtration rates (eGFRs) were consecutively measured over 6 years. The rate of declines in eGFR per year was calculated, with decreases being evaluated using a linear mixed effect model. The distribution of decreases in eGFR ≥ 30 % from baseline during the follow-up period was compared across quartiles of non-high-density lipoprotein cholesterol (HDL-C) levels using the Cochran–Armitage test. A multivariate logistic regression model was built to examine the relationship between dyslipidemia and decreases in eGFR.

Results

The prevalence of CKD increased from 8.5 to 21.2 % during the follow-up. The average of 6 annual eGFR decline rates was 2.01 ± 0.09 ml/min/1.73 m2/year, which was more than 6-fold higher than that of age-matched controls. The distribution of decreases in eGFR significantly increased across the quartiles of non-HDL-C (p value for trend = 0.0359). Non-HDL-C levels greater than the median value of the cohort were identified as a significant risk factor for decreased eGFR [odds ratio (95 % confidence interval), 1.77 (1.07–3.00)].

Conclusion

Increased non-HDL-C levels are a risk factor for renal function decline in HIV-infected patients.
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Metadata
Title
Increased non-HDL-C level linked with a rapid rate of renal function decline in HIV-infected patients
Authors
Masaki Hara
Naoki Yanagisawa
Akihito Ohta
Kumiko Momoki
Ken Tsuchiya
Kosaku Nitta
Minoru Ando
Publication date
01-04-2017
Publisher
Springer Japan
Published in
Clinical and Experimental Nephrology / Issue 2/2017
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-016-1281-9

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