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Current Neurology and Neuroscience Reports

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01-01-2013 | Nerve and Muscle (M Hirano and LH Weimer, Section Editors)

Inclusion Body Myositis

Authors: Mazen M. Dimachkie, Richard J. Barohn

Published in: Current Neurology and Neuroscience Reports | Issue 1/2013

Abstract

Sporadic inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy (IIM) after age 50 years. It presents with chronic insidious proximal leg and distal arm asymmetric muscle weakness. Despite similarities with polymyositis (PM), it is likely that IBM is primarily a degenerative disorder rather than inflammatory muscle disease. IBM is associated with a modest degree of creatine kinase (CK) elevation and an electromyogram (EMG) demonstrates a chronic irritative myopathy. Muscle histopathology demonstrates endomysial inflammatory exudates surrounding and invading non-necrotic muscle fibers often times accompanied by rimmed vacuoles. We review IBM with emphasis on recent developments in the field and discuss ongoing clinical trials.

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Title: Inclusion Body Myositis
Authors: Mazen M. Dimachkie
Richard J. Barohn
Publication date: 01-01-2013
Publisher: Current Science Inc.
Published in: Current Neurology and Neuroscience Reports / Issue 1/2013
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI: https://doi.org/10.1007/s11910-012-0321-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Inclusion Body Myositis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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