Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Obesity Surgery
Published in: Obesity Surgery 9/2014

01-09-2014 | Review Article

Incidence of Cancer Following Bariatric Surgery: Systematic Review and Meta-analysis

Authors: Daniela Schaan Casagrande, Daniela Dornelles Rosa, Daniel Umpierre, Roberta Aguiar Sarmento, Clarissa Garcia Rodrigues, Beatriz D. Schaan

Published in: Obesity Surgery | Issue 9/2014

Login to get access

Abstract

Obesity is linked to the development of cancer. Previous studies have suggested that there is a relationship between bariatric surgery and reduced cancer risk. Data sources were from Medline, Embase, and Cochrane Library. From 951 references, 13 studies met the inclusion criteria (54,257 participants). In controlled studies, bariatric surgery was associated with a reduction in the risk of cancer. The cancer incidence density rate was 1.06 cases per 1000 person-years within the surgery groups. In the meta-regression, we found an inverse relationship between the presurgical body mass index and cancer incidence after surgery (beta coefficient −0.2, P < 0.05). Bariatric surgery is associated with reduced cancer risk in morbidly obese people. However, considering the heterogeneity among the studies, conclusions should be drawn with care.
Appendix
Available only for authorised users
Literature
1.
Flegal KM, Carroll MD, Ogden CL, et al. Prevalence and trends in obesity among US adults, 1999-2008. JAMA : J Am Med Assoc. 2010;303(3):235–41. Epub 2010/01/15.CrossRef
2.
Rokholm B, Baker JL, Sorensen TI. The levelling off of the obesity epidemic since the year 1999—a review of evidence and perspectives. Obes Rev: Off J Int Assoc Study Obes. 2010;11(12):835–46. Epub 2010/10/27.CrossRef
3.
May AL, Freedman D, Sherry B, Blanck HM. Obesity—United States, 1999-2010. Morbidity and mortality weekly report Surveillance summaries (Washington, DC : 2002). 2013;62 Suppl 3:120-8. Epub 2013/11/23.
4.
Samanic C, Chow WH, Gridley G, et al. Relation of body mass index to cancer risk in 362,552 Swedish men. Cancer Causes Control. 2006;17(7):901–9.PubMedCrossRef
5.
Parekh N, Chandran U, Bandera EV. Obesity in cancer survival. Annu Rev Nutr. 2012;32:311–42. Epub 2012/05/01.PubMedCrossRef
6.
Kaidar-Person O, Bar-Sela G, Person B. The two major epidemics of the twenty-first century: obesity and cancer. Obes Surg. 2011;21(11):1792–7. Epub 2011/08/16.PubMedCrossRef
7.
Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004;4(8):579–91.PubMedCrossRef
8.
Eckel RH. Clinical practice. Nonsurgical management of obesity in adults. N Engl J Med. 2008;358(18):1941–50.PubMedCrossRef
9.
Colquitt JL, Picot J, Loveman E, et al. Surgery for obesity. Cochrane Database Syst Rev. 2009;2, CD003641.PubMed
10.
Christou NV, Sampalis JS, Liberman M, et al. Surgery decreases long-term mortality, morbidity, and health care use in morbidly obese patients. Ann Surg. 2004;240(3):416–23. discussion 23–4; Epub 2004/08/21.PubMedCentralPubMedCrossRef
11.
Sjostrom L. Bariatric surgery and reduction in morbidity and mortality: experiences from the SOS study. Int J Obes (Lond) (2005). 2008;32 Suppl 7:S93–7.
12.
McCawley GM, Ferriss JS, Geffel D, et al. Cancer in obese women: potential protective impact of bariatric surgery. J Am Coll Surg. 2009;208(6):1093–8. Epub 2009/05/30.PubMedCrossRef
13.
Sjostrom L, Gummesson A, Sjostrom CD, et al. Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial. Lancet Oncol. 2009;10(7):653–62. Epub 2009/06/27.PubMedCrossRef
14.
Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med. 2007;357(8):753–61. Epub 2007/08/24.PubMedCrossRef
15.
Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) group. JAMA : J Am Med Assoc. 2000;283(15):2008–12.CrossRef
16.
17.
Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539–58.PubMedCrossRef
18.
19.
20.
Christou NV, Lieberman M, Sampalis F, et al. Bariatric surgery reduces cancer risk in morbidly obese patients. Surg Obes Relat Dis: Off J Am Soc Bariatric Surg. 2008;4(6):691–5. Epub 2008/11/26.CrossRef
21.
Clough A, Layani L, Shah A, et al. Laparoscopic gastric banding in over 60s. Obes Surg. 2011;21(1):10–7. Epub 2010/05/22.PubMedCrossRef
22.
Forsell P, Hellers G. The Swedish Adjustable Gastric Banding (SAGB) for morbid obesity: 9 year experience and a 4-year follow-up of patients operated with a new adjustable band. Obes Surg. 1997;7(4):345–51. Epub 1997/08/01.PubMedCrossRef
23.
Gagne DJ, Papasavas PK, Maalouf M, et al. Obesity surgery and malignancy: our experience after 1500 cases. Surg Obes Relat Dis: Off J Am Soc Bariatric Surg. 2009;5(2):160–4. Epub 2008/10/14.CrossRef
24.
Gusenoff JA, Koltz PF, O'Malley WJ, et al. Breast cancer and bariatric surgery: temporal relationships of diagnosis, treatment, and reconstruction. Plast Reconstr Surg. 2009;124(4):1025–32. Epub 2009/11/26.PubMedCrossRef
25.
Marsk R, Freedman J, Tynelius P, et al. Antiobesity surgery in Sweden from 1980 to 2005: a population-based study with a focus on mortality. Ann Surg. 2008;248(5):777–81. Epub 2008/10/25.PubMedCrossRef
26.
Ostlund MP, Lu Y, Lagergren J. Risk of obesity-related cancer after obesity surgery in a population-based cohort study. Ann Surg. 2010;252(6):972–6. Epub 2010/06/24.PubMedCrossRef
27.
Sjostrom L, Narbro K, Sjostrom CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357(8):741–52. Epub 2007/08/24.PubMedCrossRef
28.
Srikanth MS, Fox SR, Oh KH, et al. Renal cell carcinoma following bariatric surgery. Obes Surg. 2005;15(8):1165–70. Epub 2005/10/04.PubMedCrossRef
29.
Steffen R, Potoczna N, Bieri N, et al. Successful multi-intervention treatment of severe obesity: a 7-year prospective study with 96 % follow-up. Obes Surg. 2009;19(1):3–12. Epub 2008/09/17.PubMedCrossRef
30.
Sugerman HJ, Sugerman EL, Wolfe L, et al. Risks and benefits of gastric bypass in morbidly obese patients with severe venous stasis disease. Ann Surg. 2001;234(1):41–6. Epub 2001/07/20.PubMedCentralPubMedCrossRef
31.
Sultan S, Gupta D, Parikh M, et al. Five-year outcomes of patients with type 2 diabetes who underwent laparoscopic adjustable gastric banding. Surg Obes Relat Dis: Off J Am Soc Bariatric Surg. 2010;6(4):373–6. Epub 2010/07/16.CrossRef
32.
Neovius M, Narbro K, Keating C, et al. Health care use during 20 years following bariatric surgery. JAMA : J Am Med Assoc. 2012;308(11):1132–41. Epub 2012/09/20.CrossRef
33.
Derogar M, Hull MA, Kant P, et al. Increased risk of colorectal cancer after obesity surgery. Ann Surg. 2013;258(6):983–8. Epub 2013/03/09.PubMedCrossRef
34.
Burza MA, Pirazzi C, Maglio C, et al. PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals. Dig liver Dis : Off J Ital Soc Gastroenterol Ital Assoc Study Liver. 2012;44(12):1037–41. Epub 2012/06/19.CrossRef
35.
Maglio C, Ericson U, Burza MA, et al. The IRS1 rs2943641 variant and risk of future cancer among morbidly obese individuals. J Clin Endocrinol Metab. 2013;98(4):E785–9. Epub 2013/02/19.PubMedCrossRef
36.
Rapp K, Schroeder J, Klenk J, et al. Obesity and incidence of cancer: a large cohort study of over 145,000 adults in Austria. Br J Cancer. 2005;93(9):1062–7. Epub 2005/10/20.PubMedCentralPubMedCrossRef
37.
Lukanova A, Bjor O, Kaaks R, et al. Body mass index and cancer: results from the Northern Sweden Health and Disease Cohort. Int J Cancer J int Cancer. 2006;118(2):458–66. Epub 2005/07/29.CrossRef
38.
Renehan AG, Tyson M, Egger M, et al. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371(9612):569–78. Epub 2008/02/19.PubMedCrossRef
39.
Birks S, Peeters A, Backholer K, et al. A systematic review of the impact of weight loss on cancer incidence and mortality. Obes Rev: Off J Int Assoc Study Obes. 2012;13(10):868–91. Epub 2012/06/08.CrossRef
40.
Topol EJ, Bousser MG, Fox KA, et al. Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial. Lancet. 2010;376(9740):517–23. Epub 2010/08/17.PubMedCrossRef
41.
James WP, Caterson ID, Coutinho W, et al. Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. N Engl J Med. 2010;363(10):905–17. Epub 2010/09/08.PubMedCrossRef
42.
Franco M, Bilal U, Ordunez P, et al. Population-wide weight loss and regain in relation to diabetes burden and cardiovascular mortality in Cuba 1980-2010: repeated cross sectional surveys and ecological comparison of secular trends. BMJ. 2013;346:f1515. Epub 2013/04/11.PubMedCrossRef
43.
DeMaria EJ, Pate V, Warthen M, et al. Baseline data from American Society for Metabolic and Bariatric Surgery-designated bariatric surgery centers of excellence using the bariatric outcomes longitudinal database. Surgery Obes Relat Dis: Off J Am Soc Bariatric Surg. 2010;6(4):347–55. Epub 2010/02/24.CrossRef
44.
Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010. CA: Cancer J Clin. 2010;60(5):277–300. Epub 2010/07/09.
45.
Bastard JP, Maachi M, Lagathu C, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006;17(1):4–12. Epub 2006/04/15.PubMed
46.
de Visser KE, Eichten A, Coussens LM. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer. 2006;6(1):24–37. Epub 2006/01/07.PubMedCrossRef
47.
Modesitt SC, Huang B, Shelton BJ, et al. Endometrial cancer in Kentucky: the impact of age, smoking status, and rural residence. Gynecol Oncol. 2006;103(1):300–6. Epub 2006/04/25.PubMedCrossRef
48.
49.
Ashrafian H, Ahmed K, Rowland SP, et al. Metabolic surgery and cancer: protective effects of bariatric procedures. Cancer. 2011;117(9):1788–99. Epub 2011/04/22.PubMedCrossRef
50.
Parker ED, Folsom AR. Intentional weight loss and incidence of obesity-related cancers: the Iowa Women's Health Study. Int J Obes Relat Metab Disord: J Int Assoc Study Obes. 2003;27(12):1447–52. Epub 2003/11/25.CrossRef
51.
Esposito K, Chiodini P, Colao A, et al. Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care. 2012;35(11):2402–11. Epub 2012/10/25.PubMedCentralPubMedCrossRef
52.
Unick JL, Beavers D, Jakicic JM, et al. Effectiveness of lifestyle interventions for individuals with severe obesity and type 2 diabetes: results from the Look AHEAD trial. Diabetes Care. 2011;34(10):2152–7. Epub 2011/08/13.PubMedCentralPubMedCrossRef
Metadata
Title
Incidence of Cancer Following Bariatric Surgery: Systematic Review and Meta-analysis
Authors
Daniela Schaan Casagrande
Daniela Dornelles Rosa
Daniel Umpierre
Roberta Aguiar Sarmento
Clarissa Garcia Rodrigues
Beatriz D. Schaan
Publication date
01-09-2014
Publisher
Springer US
Published in
Obesity Surgery / Issue 9/2014
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-014-1276-0

Other articles of this Issue 9/2014

Obesity Surgery 9/2014 Go to the issue

Original Contributions

Effect of Sleeve Gastrectomy on Gastroesophageal Reflux

Brief Communication

The Effect of PPI Use on Human Gut Microbiota and Weight Loss in Patients Undergoing Laparoscopic Roux-en-Y Gastric Bypass

Brief Communication

Childhood Verbal Abuse: A Risk Factor for Depression in Pre-Bariatric Surgery Psychological Evaluations

Original Contributions

Comparison of the Morbidity, Weight Loss, and Relative Costs between Robotic and Laparoscopic Sleeve Gastrectomy for the Treatment of Obesity in Brazil

Review Article

Systematic Review and Meta-analysis of Medium-Term Outcomes After Banded Roux-en-Y Gastric Bypass

Letter to the Editor

Reply to the Article Ben Yaacov A, Sadot E, Ben David M, Wasserberg N, Keidar A. Laparoscopic total gastrectomy with Roux-y esophagojejunostomy for chronic gastric fistula after laparoscopic sleeve gastrectomy. Obes Surg. 2014 Mar;24(3):425-9