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01-09-2014 | Brief Communication

The Effect of PPI Use on Human Gut Microbiota and Weight Loss in Patients Undergoing Laparoscopic Roux-en-Y Gastric Bypass

Authors: Emily K. Ward, Dara P. Schuster, Katie H. Stowers, Amanda K. Royse, Diana Ir, Charles E. Robertson, Daniel N. Frank, Gregory L. Austin

Published in: Obesity Surgery | Issue 9/2014

Abstract

Laparoscopic Roux-en-Y gastric bypass (LRYGB) achieves sustainable weight loss possibly by altering the gut microbiota. The effect of a proton pump inhibitor (PPI) on weight loss and the gut microbiota has not been explored. PPI use and the gut microbiota were assessed before and 6 months after LRYGB in eight patients. Bacterial profiles were generated by 16S ribosomal RNA (rRNA) gene sequencing. Prior to LRYGB, PPI users had a higher percent relative abundance (PRA) of Firmicutes compared to nonusers. PPI users at 6 months post-LRYGB had a higher PRA of Firmicutes [48.6 versus 35.6 %, p = nonsignificant (NS)] and a trend toward significantly lower percent excess weight loss (49.3 versus 61.4 %, p = 0.067) compared to nonusers. PPI use post-LRYGB may impair weight loss by modifying gut microbiota.

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Title: The Effect of PPI Use on Human Gut Microbiota and Weight Loss in Patients Undergoing Laparoscopic Roux-en-Y Gastric Bypass
Authors: Emily K. Ward
Dara P. Schuster
Katie H. Stowers
Amanda K. Royse
Diana Ir
Charles E. Robertson
Daniel N. Frank
Gregory L. Austin
Publication date: 01-09-2014
Publisher: Springer US
Published in: Obesity Surgery / Issue 9/2014
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-014-1275-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The Effect of PPI Use on Human Gut Microbiota and Weight Loss in Patients Undergoing Laparoscopic Roux-en-Y Gastric Bypass

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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