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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2011

01-02-2011 | Review

In vivoapproaches to investigate ANCA-associated vasculitis: lessons and limitations

Authors: Peter Heeringa, Mark A Little

Published in: Arthritis Research & Therapy | Issue 1/2011

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Abstract

Anti-neutrophil cytoplasm autoantibody (ANCA)-associated diseases are autoimmune conditions characterized by necrotizing inflammation of small blood vessels. The immunogenesis and etiology of these conditions are unknown, but our knowledge of the immunopathogenesis has increased considerably in recent years. In this review, we discuss the animal models currently used to investigate the mechanisms of vascular injury and to test novel therapies. We outline their advantages and limitations and propose potential directions for future research.
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Literature
1.
Berden AE, Ferrario F, Hagen EC, Jayne DR, Jennette JC, Joh K, Neumann I, Noël LH, Pusey CD, Waldherr R, Bruijn JA, Bajema IM: Histopathologic classification of ANCA-associated glomerulonephritis. J Am Soc Nephrol. 2010, 21: 1628-1636. 10.1681/ASN.2010050477.CrossRefPubMed
2.
Fauci AS, Haynes BF, Katz P, Wolff SM: Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. 1983, 98: 76-85.CrossRefPubMed
3.
Little MA, Nazar L, Farrington K: Outcome in glomerulonephritis due to systemic small vessel vasculitis: effect of functional status and non-vasculitic co-morbidity. Nephrol Dial Transplant. 2004, 19: 356-364. 10.1093/ndt/gfg551.CrossRefPubMed
4.
Little MA, Nightingale P, Verburgh CA, Hauser T, De Groot K, Savage C, Jayne D, Harper L: Early mortality in systemic vasculitis: relative contribution of adverse events and active vasculitis. Ann Rheum Dis. 2010, 69: 1036-1043. 10.1136/ard.2009.109389.CrossRefPubMed
5.
Anti neutrophil cytoplasm antibodies. Proceedings of the 1st international workshop on ANCA. Copenhagen, 1988. APMIS Suppl. 1989, 6: 1-49.
6.
Falk RJ, Jennette JC: Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med. 1988, 318: 1651-1657. 10.1056/NEJM198806233182504.CrossRefPubMed
7.
Jenne DE, Tschopp J, Ludemann J, Utecht B, Gross WL: Wegener's autoantigen decoded. Nature. 1990, 346: 520-10.1038/346520a0.CrossRefPubMed
8.
Jennette JC, Hoidal JR, Falk RJ: Specificity of anti-neutrophil cytoplasmic autoantibodies for proteinase 3. Blood. 1990, 75: 2263-2264.PubMed
9.
Jennette JC, Xiao H, Falk RJ: Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies. J Am Soc Nephrol. 2006, 17: 1235-1242. 10.1681/ASN.2005101048.CrossRefPubMed
10.
Falk RJ, Terrell RS, Charles LA, Jennette JC: Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci USA. 1990, 87: 4115-4119. 10.1073/pnas.87.11.4115.PubMedCentralCrossRefPubMed
11.
Ciavatta DJ, Yang J, Preston GA, Badhwar AK, Xiao H, Hewins P, Nester CM, Pendergraft WF, Magnuson TR, Jennette JC, Falk RJ: Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis. J Clin Invest. 2010, 120: 3209-3219. 10.1172/JCI40034.PubMedCentralCrossRefPubMed
12.
Mulder AH, Heeringa P, Brouwer E, Limburg PC, Kallenberg CG: Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA): a Fc gamma RII-dependent process. Clin Exp Immunol. 1994, 98: 270-278. 10.1111/j.1365-2249.1994.tb06137.x.PubMedCentralCrossRefPubMed
13.
Savage CO, Pottinger BE, Gaskin G, Pusey CD, Pearson JD: Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity toward cultured endothelial cells. Am J Pathol. 1992, 141: 335-342.PubMedCentralPubMed
14.
Heeringa P, Brouwer E, Tervaert JW, Weening JJ, Kallenberg CG: Animal models of anti-neutrophil cytoplasmic antibody associated vasculitis. Kidney Int. 1998, 53: 253-263. 10.1046/j.1523-1755.1998.00743.x.CrossRefPubMed
15.
Esnault VL, Mathieson PW, Thiru S, Oliveira DB, Martin-Lockwood C: Autoantibodies to myeloperoxidase in brown Norway rats treated with mercuric chloride. Lab Invest. 1992, 67: 114-120.PubMed
16.
Mathieson PW, Thiru S, Oliveira DB: Mercuric chloride-treated brown Norway rats develop widespread tissue injury including necrotizing vasculitis. Lab Invest. 1992, 67: 121-129.PubMed
17.
Brouwer E, Huitema MG, Klok PA, de Weerd H, Tervaert JW, Weening JJ, Kallenberg CG: Antimyeloperoxidase-associated proliferative glomerulonephritis: an animal model. J Exp Med. 1993, 177: 905-914. 10.1084/jem.177.4.905.CrossRefPubMed
18.
Heeringa P, Brouwer E, Klok PA, Huitema MG, Van Den Born J, Weening JJ, Kallenberg CG: Autoantibodies to myeloperoxidase aggravate mild anti-glomerular-basement-membrane-mediated glomerular injury in the rat. Am J Pathol. 1996, 149: 1695-1706.PubMedCentralPubMed
19.
Xiao H, Heeringa P, Hu P, Liu Z, Zhao M, Aratani Y, Maeda N, Falk RJ, Jennette JC: Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest. 2002, 110: 955-963.PubMedCentralCrossRefPubMed
20.
Little MA, Smyth CL, Yadav R, Ambrose L, Cook HT, Nourshargh S, Pusey CD: Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo. Blood. 2005, 106: 2050-2058. 10.1182/blood-2005-03-0921.CrossRefPubMed
21.
Xiao H, Ciavatta DJ, Zeng Y, Johnson LA, De Villena FP, Falk R, Jennette JC: Genetic control of the severity of experimental anti-MPO necrotizing and crescentic glomerulonephritis. APMIS. 2009, 117 (suppl 127): 90 (abstract)-
22.
Schreiber A, Xiao H, Falk RJ, Jennette JC: Bone marrow-derived cells are sufficient and necessary targets to mediate glomerulonephritis and vasculitis induced by anti-myeloperoxidase antibodies. J Am Soc Nephrol. 2006, 17: 3355-3364. 10.1681/ASN.2006070718.CrossRefPubMed
23.
van der Veen BS, Heeringa P: ANCA-small vessel vasculitides: what have we (not yet) learned from animal models?. APMIS Suppl. 2009, 21-26. 10.1111/j.1600-0463.2009.02472.x. 127
24.
Xiao H, Heeringa P, Liu Z, Huugen D, Hu P, Maeda N, Falk RJ, Jennette JC: The role of neutrophils in the induction of glomerulonephritis by anti-myeloperoxidase antibodies. Am J Pathol. 2005, 167: 39-45. 10.1016/S0002-9440(10)62951-3.PubMedCentralCrossRefPubMed
25.
Huugen D, Xiao H, van Esch A, Falk RJ, Peutz-Kootstra CJ, Buurman WA, Tervaert JW, Jennette JC, Heeringa P: Aggravation of anti-myeloperoxidase antibody-induced glomerulonephritis by bacterial lipopolysaccharide: role of tumor necrosis factor-alpha. Am J Pathol. 2005, 167: 47-58. 10.1016/S0002-9440(10)62952-5.PubMedCentralCrossRefPubMed
26.
Summers SA, van der Veen BS, O'Sullivan KM, Gan PY, Ooi JD, Heeringa P, Satchell SC, Mathieson PW, Saleem MA, Visvanathan K, Holdsworth SR, Kitching AR: Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Kidney Int. 2010, 78: 1263-1274. 10.1038/ki.2010.327.CrossRefPubMed
27.
Nolan SL, Kalia N, Nash GB, Kamel D, Heeringa P, Savage CO: Mechanisms of ANCA-mediated leukocyte-endothelial cell interactions in vivo. J Am Soc Nephrol. 2008, 19: 973-984. 10.1681/ASN.2007111166.PubMedCentralCrossRefPubMed
28.
Kuligowski MP, Kwan RY, Lo C, Wong C, James WG, Bourges D, Ooi JD, Abeynaike LD, Hall P, Kitching AR, Hickey MJ: Antimyeloperoxidase antibodies rapidly induce alpha-4-integrin-dependent glomerular neutrophil adhesion. Blood. 2009, 113: 6485-6494. 10.1182/blood-2008-12-192617.CrossRefPubMed
29.
Xiao H, Schreiber A, Heeringa P, Falk RJ, Jennette JC: Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies. Am J Pathol. 2007, 170: 52-64. 10.2353/ajpath.2007.060573.PubMedCentralCrossRefPubMed
30.
Schreiber A, Xiao H, Jennette JC, Schneider W, Luft FC, Kettritz R: C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis. J Am Soc Nephrol. 2009, 20: 289-298. 10.1681/ASN.2008050497.PubMedCentralCrossRefPubMed
31.
Huugen D, van Esch A, Xiao H, Peutz-Kootstra CJ, Buurman WA, Tervaert JW, Jennette JC, Heeringa P: Inhibition of complement factor C5 protects against anti-myeloperoxidase antibody-mediated glomerulonephritis in mice. Kidney Int. 2007, 71: 646-654. 10.1038/sj.ki.5002103.CrossRefPubMed
32.
Little MA, Bhangal G, Smyth CL, Nakada MT, Cook HT, Nourshargh S, Pusey CD: Therapeutic effect of anti-TNF-alpha antibodies in an experimental model of anti-neutrophil cytoplasm antibody-associated systemic vasculitis. J Am Soc Nephrol. 2006, 17: 160-169. 10.1681/ASN.2005060616.CrossRefPubMed
33.
Schreiber A, Rolle S, Peripelittchenko L, Rademann J, Schneider W, Luft FC, Kettritz R: Phosphoinositol 3-kinase-gamma mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis. Kidney Int. 2010, 77: 118-128. 10.1038/ki.2009.420.CrossRefPubMed
34.
Kettritz R, Schreiber A, Luft FC, Haller H: Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies. J Am Soc Nephrol. 2001, 12: 37-46.PubMed
35.
Polzer K, Soleiman A, Baum W, Axmann R, Distler J, Redlich K, Kilian A, Kronke G, Schett G, Zwerina J: Selective p38MAPK isoform expression and activation in antineutrophil cytoplasmatic antibody-associated crescentic glomerulonephritis: role of p38MAPKalpha. Ann Rheum Dis. 2008, 67: 602-608. 10.1136/ard.2007.077263.CrossRefPubMed
36.
van der Veen BS, Chen M, Müller R, van Timmeren MM, Petersen AH, Lee PA, Satchell SC, Mathieson PW, Saleem MA, Stegeman CA, Zwerina J, Molema G, Heeringa P: Effects of p38MAPK inhibition on ANCA pathogenicity in vitro and in vivo. Ann Rheum Dis. 2011, 70: 356-365. 10.1136/ard.2010.129106.CrossRefPubMed
37.
Hewins P, Williams JM, Wakelam MJ, Savage CO: Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fcgamma receptors and CD18. J Am Soc Nephrol. 2004, 15: 796-808. 10.1097/01.ASN.0000113241.98702.77.CrossRefPubMed
38.
van Timmeren MM, van der Veen BS, Stegeman CA, Petersen AH, Hellmark T, Collin M, Heeringa P: IgG glycan hydrolysis attenuates ANCA-mediated glomerulonephritis. J Am Soc Nephrol. 2010, 21: 1103-1114. 10.1681/ASN.2009090984.PubMedCentralCrossRefPubMed
39.
Collin M, Shannon O, Bjorck L: IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions. Proc Natl Acad Sci USA. 2008, 105: 4265-4270. 10.1073/pnas.0711271105.PubMedCentralCrossRefPubMed
40.
Pfister H, Ollert M, Frohlich LF, Quintanilla-Martinez L, Colby TV, Specks U, Jenne DE: Antineutrophil cytoplasmic autoantibodies against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in vivo. Blood. 2004, 104: 1411-1418. 10.1182/blood-2004-01-0267.CrossRefPubMed
41.
van der Geld YM, Hellmark T, Selga D, Heeringa P, Huitema MG, Limburg PC, Kallenberg CG: Rats and mice immunised with chimeric human/mouse proteinase 3 produce autoantibodies to mouse Pr3 and rat granulocytes. Ann Rheum Dis. 2007, 66: 1679-1682. 10.1136/ard.2006.064626.PubMedCentralCrossRefPubMed
42.
Primo VC, Marusic S, Franklin CC, Goldmann WH, Achaval CG, Smith RN, Arnaout MA, Nikolic B: Anti-PR3 immune responses induce segmental and necrotizing glomerulonephritis. Clin Exp Immunol. 2010, 159: 327-337. 10.1111/j.1365-2249.2009.04072.x.PubMedCentralCrossRefPubMed
43.
Franssen CF, Stegeman CA, Kallenberg CG, Gans RO, De Jong PE, Hoorntje SJ, Tervaert JW: Antiproteinase 3- and antimyeloperoxidase-associated vasculitis. Kidney Int. 2000, 57: 2195-2206. 10.1046/j.1523-1755.2000.00080.x.CrossRefPubMed
44.
Molema G: Heterogeneity in endothelial responsiveness to cytokines, molecular causes, and pharmacological consequences. Semin Thromb Hemost. 2010, 36: 246-264. 10.1055/s-0030-1253448.CrossRefPubMed
45.
van der Veen BS, Petersen AH, Belperio JA, Satchell SC, Mathieson PW, Molema G, Heeringa P: Spatiotemporal expression of chemokines and chemokine receptors in experimental anti-myeloperoxidase antibody-mediated glomerulonephritis. Clin Exp Immunol. 2009, 158: 143-153. 10.1111/j.1365-2249.2009.03993.x.PubMedCentralCrossRefPubMed
46.
de Lind van Wijngaarden RA, van Rijn L, Hagen EC, Watts RA, Gregorini G, Tervaert JW, Mahr AD, Niles JL, de Heer E, Bruijn JA, Bajema IM: Hypotheses on the etiology of antineutrophil cytoplasmic autoantibody associated vasculitis: the cause is hidden, but the result is known. Clin J Am Soc Nephrol. 2008, 3: 237-252. 10.2215/CJN.03550807.CrossRefPubMed
47.
Shoenfeld Y: Idiotypic induction of autoimmunity: a new aspect of the idiotypic network. FASEB J. 1994, 8: 1296-1301.PubMed
48.
Pendergraft WF, Preston GA, Shah RR, Tropsha A, Carter CW, Jennette JC, Falk RJ: Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3. Nat Med. 2004, 10: 72-79. 10.1038/nm968.CrossRefPubMed
49.
Kain R, Exner M, Brandes R, Ziebermayr R, Cunningham D, Alderson CA, Davidovits A, Raab I, Jahn R, Ashour O, Spitzauer S, Sunder-Plassmann G, Fukuda M, Klemm P, Rees AJ, Kerjaschki D: Molecular mimicry in pauciimmune focal necrotizing glomerulonephritis. Nat Med. 2008, 14: 1088-1096. 10.1038/nm.1874.PubMedCentralCrossRefPubMed
50.
Kallenberg CG, Stegeman CA, Heeringa P: Autoantibodies vex the vasculature. Nat Med. 2008, 14: 1018-1019. 10.1038/nm1008-1018.CrossRefPubMed
51.
Weidner S, Neupert W, Goppelt-Struebe M, Rupprecht HD: Antineutrophil cytoplasmic antibodies induce human monocytes to produce oxygen radicals in vitro. Arthritis Rheum. 2001, 44: 1698-1706. 10.1002/1529-0131(200107)44:7<1698::AID-ART294>3.0.CO;2-J.CrossRefPubMed
52.
Ralston DR, Marsh CB, Lowe MP, Wewers MD: Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha1-antitrypsin, and Fcgamma receptors. J Clin Invest. 1997, 100: 1416-1424. 10.1172/JCI119662.PubMedCentralCrossRefPubMed
53.
Weidner S, Carl M, Riess R, Rupprecht HD: Histologic analysis of renal leukocyte infiltration in antineutrophil cytoplasmic antibody-associated vasculitis: importance of monocyte and neutrophil infiltration in tissue damage. Arthritis Rheum. 2004, 50: 3651-3657. 10.1002/art.20607.CrossRefPubMed
54.
Xiao H, Heeringa P, Hu PQ, Liu Z, Falk RJ, Jennette JC: Neutrophils but not T lymphocytes are important in the induction of necrotizing and crescentic glomerulonephritis by antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase (MPO-ANCA) in mice. J Am Soc Nephrol. 2003, 14: 634A-634A (abstract).
55.
Ruth AJ, Kitching AR, Kwan RY, Odobasic D, Ooi JD, Timoshanko JR, Hickey MJ, Holdsworth SR: Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis. J Am Soc Nephrol. 2006, 17: 1940-1949. 10.1681/ASN.2006020108.CrossRefPubMed
56.
Gan PY, Steinmetz OM, Tan DS, O'Sullivan KM, Ooi JD, Iwakura Y, Kitching AR, Holdsworth SR: Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis. J Am Soc Nephrol. 2010, 21: 925-931. 10.1681/ASN.2009070763.PubMedCentralCrossRefPubMed
57.
Nogueira E, Hamour S, Sawant D, Henderson S, Mansfield N, Chavele KM, Pusey CD, Salama AD: Serum IL-17 and IL-23 levels and autoantigen-specific Th17 cells are elevated in patients with ANCA-associated vasculitis. Nephrol Dial Transplant. 2010, 25: 2209-2217. 10.1093/ndt/gfp783.CrossRefPubMed
58.
Holle JU, Wieczorek S, Gross WL: Genetic association studies in ANCA-associated vasculitides: what we have learnt so far and what needs to be done in the future. Clin Exp Rheumatol. 2010, 28 (1 Suppl 57): 5-7.PubMed
59.
Little MA, Smyth L, Salama AD, Mukherjee S, Smith J, Haskard D, Nourshargh S, Cook HT, Pusey CD: Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis. Am J Pathol. 2009, 174: 1212-1220. 10.2353/ajpath.2009.080458.PubMedCentralCrossRefPubMed
60.
Kimura Y, Zhou L, Miwa T, Song WC: Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury. J Clin Invest. 2010, 120: 3545-3554. 10.1172/JCI41782.PubMedCentralCrossRefPubMed
61.
Thurman JM, Royer PA, Ljubanovic D, Dursun B, Lenderink AM, Edelstein CL, Holers VM: Treatment with an inhibitory monoclonal antibody to mouse factor B protects mice from induction of apoptosis and renal ischemia/reperfusion injury. J Am Soc Nephrol. 2006, 17: 707-715. 10.1681/ASN.2005070698.CrossRefPubMed
Metadata
Title
In vivoapproaches to investigate ANCA-associated vasculitis: lessons and limitations
Authors
Peter Heeringa
Mark A Little
Publication date
01-02-2011
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2011
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3236

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