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European Radiology
Published in: European Radiology 12/2016

Open Access 01-12-2016 | Neuro

In vivo proton magnetic resonance spectroscopy (1H-MRS) evaluation of the metabolite concentration of optic radiation in primary open angle glaucoma

Authors: Sabrilhakim Sidek, Norlisah Ramli, Kartini Rahmat, Norlina Mohd Ramli, Fadzlina Abdulrahman, Tan Li Kuo

Published in: European Radiology | Issue 12/2016

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Abstract

Objective

To compare the metabolite concentration of optic radiation in glaucoma patients with that of healthy subjects using Proton Magnetic Resonance Spectroscopy (1H-MRS).

Methods

1H-MRS utilising the Single-Voxel Spectroscopy (SVS) technique was performed using a 3.0Tesla MRI on 45 optic radiations (15 from healthy subjects, 15 from mild glaucoma patients, and 15 from severe glaucoma patients). A standardised Volume of Interest (VOI) of 20 × 20 × 20 mm was placed in the region of optic radiation. Mild and severe glaucoma patients were categorised based on the Hodapp–Parrish–Anderson (HPA) classification. Mean and multiple group comparisons for metabolite concentration and metabolite concentration ratio between glaucoma grades and healthy subjects were obtained using one-way ANOVA.

Results

The metabolite concentration and metabolite concentration ratio between the optic radiations of glaucoma patients and healthy subjects did not demonstrate any significant difference (p > 0.05).

Conclusion

Our findings show no significant alteration of metabolite concentration associated with neurodegeneration that could be measured by single-voxel 1H-MRS in optic radiation among glaucoma patients.

Key Points

• Glaucoma disease has a neurodegenerative component.
• Metabolite changes have been observed in the neurodegenerative process in the brain.
• Using SVS, no metabolite changes in optic radiation were attributed to glaucoma.
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Metadata
Title
In vivo proton magnetic resonance spectroscopy (1H-MRS) evaluation of the metabolite concentration of optic radiation in primary open angle glaucoma
Authors
Sabrilhakim Sidek
Norlisah Ramli
Kartini Rahmat
Norlina Mohd Ramli
Fadzlina Abdulrahman
Tan Li Kuo
Publication date
01-12-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 12/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4279-5

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