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European Radiology

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01-05-2013 | Magnetic Resonance

In vivo MRI assessment of placental and foetal oxygenation changes in a rat model of growth restriction using blood oxygen level-dependent (BOLD) magnetic resonance imaging

Authors: S. Aimot-Macron, L. J. Salomon, B. Deloison, R. Thiam, C. A. Cuenod, O. Clement, N. Siauve

Published in: European Radiology | Issue 5/2013

Abstract

Objectives

To evaluate whether changes in BOLD signal intensities following hyperoxygenation are related to intrauterine growth restriction (IUGR) in a rat model.

Methods

IUGR was induced in pregnant rats by ligating the left vascular uterine pedicle at day 16 of gestation. BOLD MR imaging using a balanced steady-state free-precession (balanced-SSFP) sequence on a 1.5-T system was performed on day 19. Signal intensities (SI) before and after maternal hyperoxygenation were compared in the maternal liver and in control and growth-restricted foetoplacental units (FPUs).

Results

Maternal hyperoxygenation resulted in a significant increase in SI in all regions of interest (P < 0.05) in the 18 rats. In the control group, the SI (mean ± SD) increased by 21 % ± 15 in placentas (n = 74) and 13 % ± 8.5 in foetuses (n = 53). In the IUGR group, the increase was significantly lower: 6.5 % ± 4 in placentas (n = 36) and 7 % ± 5.5 in foetuses (n = 34) (P < 0.05).

Conclusion

BOLD MRI allows non-invasive assessment of the foetoplacental response to maternal hyperoxygenation in the rat and demonstrates its alteration in an IUGR model. This imaging method may provide a useful adjunct for the early diagnosis, evaluation, and management of human IUGR.

Key Points

• Intra-uterine growth restriction is an important cause of perinatal morbidity and mortality.

• Blood oxygen level-dependent MRI non-invasively assesses foetoplacental response to maternal hyperoxygenation.

• In the rat, foetoplacental response to maternal hyperoxygenation is altered in IUGR.

• Functional MRI may help to assess human IUGR.

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Title: In vivo MRI assessment of placental and foetal oxygenation changes in a rat model of growth restriction using blood oxygen level-dependent (BOLD) magnetic resonance imaging
Authors: S. Aimot-Macron
L. J. Salomon
B. Deloison
R. Thiam
C. A. Cuenod
O. Clement
N. Siauve
Publication date: 01-05-2013
Publisher: Springer-Verlag
Published in: European Radiology / Issue 5/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2712-y

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Springer Medicine

In vivo MRI assessment of placental and foetal oxygenation changes in a rat model of growth restriction using blood oxygen level-dependent (BOLD) magnetic resonance imaging

Abstract

Objectives

Methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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