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Virology Journal
Published in: Virology Journal 1/2013

Open Access 01-12-2013 | Research

In vitro inhibition of mumps virus by retinoids

Authors: Kaitlin J Soye, Claire Trottier, Thomas Z Di Lenardo, Katherine H Restori, Lee Reichman, Wilson H Miller Jr, Brian J Ward

Published in: Virology Journal | Issue 1/2013

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Abstract

Background

Mumps virus (MuV) is a highly infectious paramyxovirus closely related to measles virus (MeV). Despite the availability of a mumps vaccine, outbreaks continue to occur and no treatment options are available. Vitamin A and other naturally occurring retinoids inhibit the replication of MeV in vitro.

Methods

Anti-viral effects of retinoids were observed in cell culture using the myelomonocytic U937, NB4/R4, and Huh7/7.5 cells. Observations of anti-viral effect were quantified using TCID50 analysis. Molecular properties of the antiviral effect were analysed using quantitative RT-PCR and western blot.

Results

The current work demonstrates that retinoids inhibit MuV in vitro due to up-regulation of type I interferon (IFN) and IFN stimulated genes. This effect is mediated by nuclear retinoid receptor signalling and RIG-I is required. The antiviral retinoid-induced state makes cells less permissive to viral replication from subsequent challenge with either MuV or MeV for less than 12 hours.

Conclusions

These results demonstrate that retinoids inhibit MuV replication in uninfected bystander cells through a retinoid inducible gene I (RIG-I), retinoic acid receptor (RAR) and IFN dependent manner making them refractory to subsequent rounds of viral replication. These observations raise the possibility that pharmacological doses of retinoids might have clinical benefit in MuV infection.
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Metadata
Title
In vitro inhibition of mumps virus by retinoids
Authors
Kaitlin J Soye
Claire Trottier
Thomas Z Di Lenardo
Katherine H Restori
Lee Reichman
Wilson H Miller Jr
Brian J Ward
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2013
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/1743-422X-10-337

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