Top

Journal of Assisted Reproduction and Genetics

Published in:

01-11-2011 | ASSISTED REPRODUCTION TECHNOLOGIES

In vitro fertilization and embryo transfer outcomes in relation to myometrial thickness

Authors: Hyun Sik Youm, Young Sik Choi, Hyuck Dong Han

Published in: Journal of Assisted Reproduction and Genetics | Issue 11/2011

Abstract

Purpose

To evaluate the effects of myometrial thickening on the outcomes of in vitro fertilization and embryo transfer (IVF-ET).

Methods

Four hundred thirteen patients, a total of 551 IVF-ET cycles, were divided into group A (<2.00 cm), group B (2.00–2.49 cm), and group C (≥2.50 cm) based on myometrial thickness.

Results

The implantation, clinical pregnancy, and live birth rates were significantly lower in group C. The abortion rates were significantly higher in group C. Among patients in group B, cases with other sonographic findings suggestive of adenomyosis, such as myometrial striations, heterogeneous myometrium, myometrial cysts, and poor definition of the endometrial–myometrial junction showed lower implantation, clinical pregnancy, live birth rates, and higher abortion rates.

Conclusions

Myometrial thickening of more than 2.50 cm on TVUS exerts overall adverse effects on IVF-ET outcomes. Even with mild thickening (2.00–2.49 cm), the presence of sonographic findings suggestive of adenomyosis is associated with adverse outcomes of IVF-ET.

Kido A, Togashi A, Koyama T, Yamaoka T, Fugiwara T, Fujii S. Diffusely enlarged uterus: evaluation with MR imaging. Radiographics. 2003;23:1423–39.PubMedCrossRef

Matalliotakis IM, Kourtis AI, Panidis DK. Adenomyosis. Obstet Gynecol Clin North Am. 2003;30:63–82.PubMedCrossRef

Wang PH, Su WH, Sheu BC, Liu WM. Adenomyosis and its variance: adenomyoma and female fertility. Taiwan J Obstet Gynecol. 2009;48:232–8.PubMedCrossRef

Gordts S, Brosens JJ, Fusi L, Benagiano G, Brosens I. Uterine adenomyosis: a need for uniform terminology and consensus classification. Reprod Biomed Online. 2008;17:244–8.PubMedCrossRef

Levgur M. Diagnosis of adenomyosis: a review. J Reprod Med. 2007;52:177–93.PubMed

Kepkep K, Tuncay YA, Göynümer G, Tutal E. Transvaginal sonography in the diagnosis of adenomyosis: which findings are most accurate? Ultrasound Obstet Gynecol. 2007;30:341–5.PubMedCrossRef

Sun YL, Wang CB, Lee CY, Wun TH, Lin P, Lin YH, et al. Transvaginal sonographic criteria for the diagnosis of adenomyosis based on histopathologic correlation. Taiwan J Obstet Gynecol. 2010;49:40–4.PubMedCrossRef

Dueholm M, Lundorf E. Transvaginal ultrasound or MRI for diagnosis of adenomyosis. Curr Opin Obstet Gynecol. 2007;19:505–12.PubMedCrossRef

Bazot M, Cortez A, Darai E, Rouger J, Chopier J, Antoine JM, et al. Ultrasonography compared with magnetic resonance imaging for the diagnosis of adenomyosis: correlation with histopathology. Hum Reprod. 2001;16:2427–33.PubMed

10.

Hulka CA, Hall DA, McCarthy K, Simeone J. Sonographic findings in patients with adenomyosis: can sonography assist in predicting extent of disease? Am J Roentgenol. 2002;179:379–83.

11.

Reinhold C, Tafazoli F, Mehio A, Wang L, Atri M, Siegelman ES, et al. Uterine adenomyosis: endovaginal US and MR imaging features with histopathologic correlation. Radiographics. 1999;19:S147–60.PubMed

12.

Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nygren K, et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Hum Reprod. 2009;24:2683–7.PubMedCrossRef

13.

Anderson JR, Genadry R. Anatomy and embryology. In: Berek JS, editor. Berek & Novak’s gynecology. 14th ed. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 75–127.

14.

Levi CS, Lyons EA, Holt SC, Dashefsky SM. Normal anatomy of the female pelvis and transvaginal sonography. In: Callen PW, editor. Ultrasonography in obstetrics and gynecology. 5th ed. Philadelphia: Saunders; 2008. p. 887–918.

15.

Traiman P, Saldiva P, Haiashi A, Franco M. Criteria for the diagnosis of diffuse uterine myohypertrophy. J Gynaecol Obstet. 1996;54:31–6.

16.

Camargo F, Gaytan J, Caligara C, Simón C, Pellicer A, Remohí J. Impact of ultrasound diagnosis of adenomyosis on recipients of sibling oocytes. Fertil Steril. 2001;76 Suppl 1:S150.CrossRef

17.

Chiang CH, Chang MY, Shiau CS, Hou HC, Hsieh TT, Soong YK. Effect of a sonographically diffusely enlarged uterus without distinct uterine masses on the outcome of in vitro fertilization-embryo transfer. J Assist Reprod Genet. 1999;16:369–72.PubMedCrossRef

18.

Leyendecker G, Kunz G, Kissler S, Wildt L. Adenomyosis and reproduction. Best Pract Res Clin Obstet Gynaecol. 2006;20:523–46.PubMedCrossRef

19.

Devlieger R, D’Hooghe T, Timmerman D. Uterine adenomyosis in the infertility clinic. Hum Reprod Update. 2003;9:139–47.PubMedCrossRef

20.

Olive DL, Franklin RR, Gratkins LV. The association between endometriosis and spontaneous abortion. A retrospective clinical study. J Reprod Med. 1982;27:333–8.PubMed

21.

Ota H, Igarashi S, Hatazawa J, Tanaka T. Is adenomyosis an immune disease? Hum Reprod Update. 1998;4:360–7.PubMedCrossRef

22.

Raine-Fenning NJ, Campbell BK, Kendall NR, Clewes JS, Johnson IR. Endometrial and subendometrial perfusion are impaired in women with unexplained subfertility. Hum Reprod. 2004;19:2605–14.PubMedCrossRef

23.

Chien LW, Au HK, Chen PL, Xiao J, Tzeng CR. Assessment of uterine receptivity by the endometrial-subendometrial blood flow distribution pattern in women undergoing in vitro fertilization-embryo transfer. Fertil Steril. 2002;78:245–51.PubMedCrossRef

24.

Zaidi J, Campbell S, Tittrof R, Tan SL. Endometrial thickness, morphology, vascular penetration and velocimetry in predicting implantation in an in vitro fertilization program. Ultrasound Obstet Gynecol. 1995;6:191–8.PubMedCrossRef

Title: In vitro fertilization and embryo transfer outcomes in relation to myometrial thickness
Authors: Hyun Sik Youm
Young Sik Choi
Hyuck Dong Han
Publication date: 01-11-2011
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 11/2011
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-011-9640-7

At a glance: The STEP trials

Springer Medicine

In vitro fertilization and embryo transfer outcomes in relation to myometrial thickness

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 11/2011

Clinical diagnostic testing for the cytogenetic and molecular causes of male infertility: the Mayo Clinic experience

Cancer therapy and fertility preservation

Epigenetic modification does not determine the time of POU5F1 transcription activation in cloned bovine embryos

Brain-derived neurotrophic factor from follicular fluid is positively associated with rate of mature ooocytes collected and cleavage rate in intracytoplasmic sperm injection patients

Other abstracts

Oocyte embryo cyropreservation